Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2829-2833

  Kung, Pei Pei ^a   Zehnder, Luke R ^a   Meng, Jerry J ^a   Kupchinsky, Stanley W ^a   Skalitzky, Donald J ^a   Johnson, M Catherine ^a   Maegley, Karen A ^a   Ekker, Anne ^a   Kuhn, Leslie A ^a   Rose, Peter W ^a   Bloom, Laura A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE; 5' METHYLTHIOADENOSINE PHOSPHORYLASE; BENZYL DERIVATIVE; HETEROCYCLIC COMPOUND; PHENYL GROUP; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE;

ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE;

DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PURINE-NUCLEOSIDE PHOSPHORYLASE; SUBSTRATE SPECIFICITY;

EID: 21144443515     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.107     Document Type: Article

References (23)

1. Y.M. Rustum, H. Takita, and G. Gomez Antibiot. Chemother. 28 1980 86
2. Y. Natsumeda, N. Prajda, J.P. Donohue, J.L. Glover, and G. Weber Cancer Res. 44 1984 2475
3. S.J. Benkovic Trends Biochem. Sci. 9 1984 320
4. N. Kamatani, and D.A. Carson Biochim. Biophys. Acta 675 1981 344
5. J.H. Fitchen, M.K. Riscoe, B.W. Dana, and H.J. Lawrence Cancer Res. 46 1986 5409
6. T. Nobori, I. Szinai, D. Amox, B. Parker, O.I. Olopade, D.L. Buchhagen, and D.A. Carson Cancer Res. 53 1993 1098
7. T. Nobori, K. Takabayashi, P. Tran, L. Orvis, A. Batova, and A.L. Yu Proc. Natl. Acad. Sci. U.S.A. 93 1996 6203
8. A. Batova, M.B. Diccianni, M. Omura-Minamisawa, J. Yu, C.J. Carrera, L.J. Bridgeman, F.H. Kung, J. Pullen, M.D. Amylon, and A.L. Yu Cancer Res. 59 1999 1492
9. H. Hori, P. Tran, C.J. Carrera, Y. Hori, M.D. Rosenbach, D.A. Carson, and T. Nobori Cancer Res. 56 1996 5653
10. L.A. Bloom, J.S. Piraino, E.G. Lorenzana, and T.J. Boritzki Proc. Am. Assoc. Cancer Res. 2004 Abstract no.: 4000
11. F. Robert, C. Garrett, W.R. Dinwoodie, D.M. Sullivan, M. Bishop, M. Amantea, M. Zhang, and S.D. Reich Proc. Am. Assoc. Clin. Oncol. 2004 Abstract no.: 3075
12. L.Y. Ghoda, T.M. Savarese, C.H. Northup, R.E. Parks, J. Garofalo, L. Katz, B.B. Ellenbogen, and C.J. Bacchi Mol. Biochem. Parasitol. 27 1988 109
13. T.C. Appleby, M.D. Erion, and S.E. Ealick Structure 7 1999 629
14. M.W. White, A.A. Vandenbark, C.L. Barney, and A. Ferro Biochem. Pharmacol. 31 1982 503
15. Compounds 3 and 4: D. Guillerm, G. Guillerm, and C. Witkowski-Vandenplas Nucleosides Nucleotides 20 2001 689
16. compound 5: A.M. Kawasaki, M.D. Casper, S.M. Freier, E.A. Lesnik, M.C. Zounes, L.L. Cummins, and P.D. Cook J. Med. Chem. 36 1993 831
17. compound 7: J.A. Montgomery, A.T. Shortnacy, and H.J. Thomas J. Med. Chem. 17 1974 1197
18. M. Gavagnin, and G. Sodano Nucleosides Nucleotides 8 1989 1319
19. M.J. Robins, F. Hansske, S.F. Wnuk, and T. Kanai Can. J. Chem. 69 1991 1468
20. H. Li, and M.J. Miller J. Org. Chem. 64 1999 9289
21. M. Kolb, C. Danzin, J. Barth, and N. Claverie J. Med. Chem. 25 1982 550
22. J.A. Montgomery, A.G. Laseter, and K. Hewson J. Heterocycl. Chem. 11 1974 211
23. T.M. Savarese, G.W. Crabtree, and R.E. Parks Jr. Biochem. Pharmacol. 30 1980 189