Feasibility study: Fast liquid chromatography-mass spectrometry for the quantification of aspartic acid in an aspartate drug

Analytical and Bioanalytical Chemistry

Volumn 377, Issue 7-8, 2003, Pages 1120-1123

  Schmidt, Jochen ^a  

^a Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

Aspartate drug; Aspartic acid; Electrospray ionization; Fast HPLC MS; Quantification; Selected ion monitoring

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; OPTIMIZATION; STANDARDIZATION;

ASPARTATE DRUG; ASPARTIC ACID; ELECTROSPRAY IONIZATION; FAST HPLC-MS; QUANTIFICATION; SELECTION ION MONITORING;

AMINO ACIDS;

EID: 21144438644     PISSN: 16182642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00216-003-2243-0     Document Type: Conference Paper

References (8)

1. ICH (1999) Specifications: Test procedures and acceptance criteria for new drug substances and drug products: chemical substances. International Conference on Harmonization, ICH harmonized tripartite guideline Q6A, 6 Oct 1999
2. Blume HH, Cartwright AC, Möller H (1996) Setting specifications for drug substances and drug products. Report on a conference organized by the International Pharmaceutical Federation (FTP) together with the Bundesverband der Pharmazeutischen Industrie (BPI), the Verband der Forschenden Arzneimittelhersteller (VFA), and the European Federation for Pharmaceutical Sciences (EUFEPS), 17-19 May 1995, Bad Homburg, Germany. Pharm Ind 58:106-11
3. Schuster R (1988) Determination of amino acids in biological, pharmaceutical, plant and food samples by automated precolumn derivatization and high-performance liquid chromatography. J Chromatogr A 431:271-84
4. Soga T, Heiger DN (2000) Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrometry. Anal Chem 72:1236-1241
5. Martin-Girardeau A, Renou-Gonnord MF (2000) Optimization of a capillary electrophoresis - electrospray mass spectrometry method for the quantification of the 20 natural amino acids in children's blood. J Chromatog B 742:163-171
6. Chaimbault P, Petritis K, Elfakir C, Dreux M (1999) Determination of 20 underivatized proteinic amino acids by ion-pairing chromatography and pneumatically assisted electrospray mass spectrometry. J Chromatogr A 855:191-202
7. Hiraoka K, Murata K, Kudaka I (1995) Do the electrospray mass spectra reflect the ion concentrations in sample solution? J Mass Spectrom Soc Jpn 43:127-137
8. Mansoor BA, Volmer DA, Boyd RK (1997) 'Wrong-way-round' electrospray ionization of amino acids. Rapid Commun Mass Spectrom 11:1120-1130