Effect of blood flow on gas transport in a pulmonary capillary

Journal of Biomechanical Engineering

Volumn 127, Issue 3, 2005, Pages 432-439

  Merrikh, Ali A ^a,b   Lage, José L ^a  

^a Southern Methodist University   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BLOOD VESSELS; CAPILLARY FLOW; COMPUTER SIMULATION; DIFFUSION; MORPHOLOGY; PLASMA FLOW; RESPIRATORY SYSTEM;

BLOOD FLOW; CAPILLARY HEMATOCRIT (HT); CONVECTION-DIFFUSION PHENOMENON; GAS TRANSPORT;

HEMODYNAMICS;

CARBON MONOXIDE;

ARTICLE; BLOOD FLOW VELOCITY; ERYTHROCYTE; GAS DIFFUSION; HEMATOCRIT; LUNG CAPILLARY; LUNG DIFFUSION CAPACITY; LUNG VOLUME; MATHEMATICAL MODEL; PLASMA; SCANNING ELECTRON MICROSCOPY; THERMODYNAMICS;

BIOLOGICAL TRANSPORT, ACTIVE; BLOOD FLOW VELOCITY; CAPILLARIES; CARBON DIOXIDE; COMPUTER SIMULATION; ERYTHROCYTES; HUMANS; LUNG; MODELS, CARDIOVASCULAR; OXYGEN; PULMONARY GAS EXCHANGE;

EID: 21144433986     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.1894322     Document Type: Article

References (23)

1. Krogh, A., and Krogh, M., 1909, "Rate of Diffusion into Lungs of Men," Skand. Arch. Physiol., 23, pp. 236-247.
2. American Thoracic Society, 1995, "Single Breath Carbon Monoxide Diffusing Capacity (Transfer Factor): Recommendations for a Standard Technique, Am. J. Respir. Crit. Care Med., 152, 2185-2198.
3. C) Components, Resp. Phys. Neurobiology 138, 155-142.
4. Krogh, M., 1915, The diffusion of gases through the lungs of man, J. Physiol. (London), 49, 271-296.
5. Comroe, J. H., Jr., Forster, R. E., Dubois, A. B., Briscoe, W. A., and Carlsen, E., 1962, The Lung: Clinical Physiology and Pulmonary Function Tests, 2nd ed., Year Book Medical Publishers, Chicago, ( reprint, 1974).
6. Roughton, F. J. W., and Forster, R. E., 1957, Relative importance of diffusion and chemical reaction rates in determining the rate of exchange of gases in human lung, with special reference to true diffusion capacity of the pulmonary membrane and volume of blood in lung capillaries, J. Appl. Physiol., 11, 290-302.
7. Johnson, R. L., Jr., Taylor, H. F., and DeGraff, A. C., 1965, Functional Significance of a Low Pulmonary Diffusing Capacity for Carbon Monoxide, J. Clin. Invest, 44, 789-800.
8. Weibel, E. R., 1970, Morphometric estimation of pulmonary diffusion capacity, I. Model and method, Respir. Physiol., 11, 54-75.
9. Lage, J. L., Merrikh, A. A., and Kulish, V. V., 2004, "A Porous Medium Model to Investigate the Red Cell Distribution Effect on Alveolar Respiration: Numerical Simulations to CO Diffusion in the Alveolar Region of the Lungs," Emerging Technologies and Techniques in Porous Media, vol. 1, chap. 25, pp. 381-407, Kluwer Academic, Dordrecht, The Netherlands.
10. Kulish, V. V., Lage, J. L., Hsia, C. C. W., and Johnson, R. L., Jr., 2002, "Three-dimensional, unsteady simulation of alveolar respiration, ASME J. Biomech. Eng., 124, 609-616.
11. Hellumus, J. D., 1977 The Resistance to Oxygen Transport in the Capillaries Relative to That in the Surrounding Ttissue. Microvasc. Res., 13, 131-136.
12. Federspiel, W. J., and Popel, A. S., 1986, A Theoretical Analysis of the Effect of the Particulate Nature of Blood on Oxygen Release in Capillaries, Microvasc. Res., 32, 164-169.
13. Fedrespiel, W. J., 1989 Pulmonary diffusing capacity: implications of two-phase blood flow in capillaries, Respir. Physiol., 77, 119-134.
14. Hsia, C. C. W., Chuong, C. J. C., and Johnson, R. L., Jr., 1995, Critique of conceptual basis of diffusion capacity estimates: A finite element analysis, J. Appl. Physiol., 79, 1039-1047.
15. Hsia, C. C. W., Chuong, C. J. C., and Johnson, Jr., R. L., 1997 Red cell distortion and conceptual basis of diffusion capacity estimates: a finite element analysis, J. Appl. Physiol., 83, 1397-1404.
16. Frank, A. O., Chuong, C. J. C., and Johnson, Jr., R. L., 1997 A finite element model of oxygen diffusion in the pulmonary capillaries, J. Appl. Physiol., 82, 2036-2044.
17. Aroesty, J., and Gross, J. F., 1970, Convection and diffusion in the microcirculation, Microvasc. Res., 2, 247-267.
18. Groebe, K., and Thews, G., 1989 Effect of red cell spacing and red cell movement upon oxygen release under conditions of maximally working skeletal muscle, Adv. Exp. Med. Biol., 248, 175-185.
19. Patel, S., 2002 Evaluation of the resistance of membrane and erythrocytes to oxygen transport in pulmonary capillaries, Resp Physiol & Neorobio, 130, 181-187.
20. Honig, C. R., and Odoroff, C. L., 1981, Calculated dispersion of capillary transit times: Significance for oxygen exchange, Am. J. Physiol., 240, 199-208, 1981.
21. Popel, A., 1989 Theory of oxygen transport to tissue, Crit. Rev. Biomed. Eng., 17-3, 257-321.
22. Bloch, E. H., 1962 A quantitative study of the hemodynamics in the living microvascular system, Am. J. Anat., 110, 125-145.
23. Patankar, S., 1980, Numerical Heat Transfer and. Fluid Flow, Hemisphere, Washington DC.