Hemodynamic effects of acute administration of atomoxetine and methylphenidate

Journal of Clinical Pharmacology

Volumn 45, Issue 7, 2005, Pages 851-855

  Kelly, Ronan P ^a   Yeo, Kwee Poo ^a   Teng, Choo Hua ^a   Smith, Brian P ^b   Lowe, Stephen ^a   Soon, Danny ^a   Read, Holly A ^b   Wise, Stephen D ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Atomoxetine; Blood pressure; Cathecolamines; Heart rate; Methylphenidate

Indexed keywords

ATOMOXETINE; CATECHOLAMINE; METHYLPHENIDATE; PLACEBO;

ACUTE DRUG ADMINISTRATION; ADULT; ARTICLE; BLOOD PRESSURE; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG MECHANISM; DRUG TOLERABILITY; HEART PALPITATION; HEART RATE; HEMODYNAMICS; HUMAN; MALE; NORMAL HUMAN; ORTHOSTATIC HYPOTENSION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINUS TACHYCARDIA; SYSTEMIC VASCULAR RESISTANCE; TACHYCARDIA; THIRST; XEROSTOMIA;

ADRENERGIC AGENTS; ADRENERGIC UPTAKE INHIBITORS; ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EPINEPHRINE; HEART RATE; HUMANS; MALE; METHYLPHENIDATE; NOREPINEPHRINE; PROPYLAMINES;

EID: 21044457538     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270005276737     Document Type: Article

References (8)

1. Michelson D, Allen AJ, Busner J, et al. Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study. Am J Psychiatry. 2002;159:1896-1901.
2. Spencer T, Heiligenstein JH, Biederman J, et al. Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2002;63:1140-1147.
3. Ring BJ, Gillespie JS, Eckstein JA, Wrighton SA. Identification of the human cytochromes P450 responsible for atomoxetine metabolism. Drug Metab Dispos. 2002;30:319-323.
4. Joyce PR, Nicholls MG, Donald RA. Methylphenidate increases heart rate, blood pressure and plasma epinephrine in normal subjects. Life Sci. 1984;34:1707-1711.
5. Wernicke JF, Faries D, Girod D, et al. Cardiovascular effects of atomoxetine in children, adolescents, and adults. Drug Saf. 2003;26:729-740.
6. Wilens TE, Biederman J, Lerner M; Concerta Study Group. Effects of once-daily osmotic-release methylphenidate on blood pressure and heart rate in children with attention-deficit/hyperactivity disorder: results from a one-year follow-up study. J Clin Psychopharmacol. 2004;24:36-41.
7. Heil SH, Holmes HW, Bickel WK, et al. Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users. Drug Alcohol Depend. 2002;67:149-156.
8. Newcorn J. Efficacy trials of atomoxetine for ADHD in children, adolescents and adults [abstract 40B]. Paper presented at: the 49th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; October 25, 2002; San Francisco, Calif.