Hypotensive effects of tablet containing γ-amino butyric acid (GABA) on high normal blood pressure and mild hypertensive subjects

Japanese Pharmacology and Therapeutics

Volumn 32, Issue 12, 2004, Pages 929-944

  Kajimoto, Osami ^a   Ueno, Hirofumi ^b   Nagata, Yasuo ^b   Yabune, Mitsuharu ^c   Kajimoto, Yoshitaka ^c  

^a OSAKA UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c Soiken Inc   (Japan)

Author keywords

Amino butyric acid (GABA) hypotensive effects; High normal blood pressure; Mild hypertension

Indexed keywords

4 AMINOBUTYRIC ACID; PLACEBO;

ADULT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD EXAMINATION; BLOOD PRESSURE; BORDERLINE HYPERTENSION; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERTENSION; MALE; PHYSICAL EXAMINATION; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; SYSTOLIC BLOOD PRESSURE; TEST MEAL; URINALYSIS;

EID: 21044444077     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Guidelines subcommittee. 1999 World Health Organization-International Society of Hypertension guidelines for the management of hypertension. J Hypertens 1999; 17: 151-83.
2. Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y. A placebo-controlled study of the effects of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 1996; 64: 767-71.
3. Nat Med 1998; 51: 392-8.
4. Ther Res 1997; 18: 570-3.
5. Takahashi H, Tiba M, Iino M, Takayasu T. The effect of γ-aminobutyric acid on blood pressure. Jpn J Physiol 1955; 5: 334-41.
6. Elliot KAC, Hobbiger F. Gamma aminobutyric acid: circulatory and respiratory effects in different species: reinvestigation of the anti-strychnine action in mice. J Physiol 1959; 146: 70-84.
7. Onoda A, Saikusa T, Horino T, Kajimoto O, Miyamoto A, Tanaka Y, et al. Accumulative effects of γ-aminobutylic acid (GABA) for dedatted germ. The first international symposium on disease prevent by IP6 & other rice components, 1988; p.97.
8. Matsubara F, Ueno H, Muneyuki T, Tadano K, Toyama T, Imaizumi K, et al. Effects of GABA suplementation on blood pressure and safety in adults with mild hypertension. Jpn Pharmacol Ther 2002; 30 (11): 963-72
9. Imai Y, Ohkubo T, Hozawa A, Tsuji I, Matsubara M, Araki T. Usefulness of home blood pressure measurements in assessing the effect of treatment in a single-blind placebo-controlles open trial. J Hypertens 2001; 19: 179-85.
10. http://www.cpt.med.tohoku.ac.jp/HOMED-BP/ index.html
11. Kawasaki T, Itoh K, Uezono K, Sasaki H. Estimation of 24-hour urinary sodium and potassium excretion from predicted value of 24-hour urinary creatinine excretion and fractional urine sodium/creatinine and potassium/creatinine ratio.Sventh Symposium on Salt II 1993; 257-62.
12. Billingsley M, Suria A, Gilman R, Shokes L, Shahvari M. Evidence for GABA inviloment in the peripheral control of blood pressure and vascular resistance. Brain Res Bull 1980; 5 (Suppl 2): 329-33.
13. Stanton HC. Mode of action of gamma amino butyric acid on the cardiovascular system. Arch Int Pharmacodyn 1963; 143 (1-2): 195-204.
14. Hayakawa K, Kimura M, Kamata K. Mechanism underlying γ-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive effect in spontaneously hypertensive rats. Eur J Pharmacol 2002; 438: 107-13.
15. Fujimura S, Shimakage H, Tanioka H, Yoshida M, Suzuki-Kusaba M, Hisa H. Effect of GABA on noradrenaline release and vasoconstriction induced by renal nerve stimuration in isolated perfused rat kidney. Br J Pharmacol 1999; 127(1): 109-14.
16. Iovino M, Caro GD, Massi M, Steado L, Poenaru S. Muscimol inhibits ADH release induced by hypertonic sodium chloride in rats. Pharmacol Biochem Behav 1983; 19: 335-8.
17. Eric MH, Casey AS, Matilde AH, Tony GW. Decrease in glutamic acid decarboxylase level in the hypotharamus of spontaneously hypertensive rats. J Hypertens 1998; 16: 625-33.