Inhibitory effects of cadmium on peripheral blood mononuclear cell proliferation and cytokine release are reversed by zinc and selenium salts

Annals of Clinical and Laboratory Science

Volumn 35, Issue 2, 2005, Pages 115-120

  Boscolo, Paolo ^a   Di Giampaolo, Luca ^a   Qiao, Niu ^b   Reale, Marcella ^a   Castellani, Maria Luisa ^a   Lucci, Isabella ^a   Travaglini, Paola ^a   Kouri, Mary ^a   Verna, Nicola ^a   Volpe, Anna Rita ^c   Carmignani, Marco ^c   Paganelli, Roberto ^a   Di Gioacchino, Mario ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SHANXI MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Cadmium; Cytokine; Immunotoxicity; Lymphocyte proliferation; Selenium; Zinc

Indexed keywords

CADMIUM; CADMIUM SULFATE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 5; SELENIUM; TUMOR NECROSIS FACTOR ALPHA; ZINC; ZINC SULFATE;

ADULT; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DENSITY GRADIENT CENTRIFUGATION; ENZYME IMMUNOASSAY; HUMAN; KOLMOGOROV SMIRNOV TEST; LEUKOCYTE COUNT; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

CADMIUM COMPOUNDS; CELL PROLIFERATION; CYTOKINES; HUMANS; LYMPHOCYTES; MALE; SODIUM SELENITE; SULFATES; ZINC SULFATE;

EID: 21044440408     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Friberg L, Piscator M, Nordberg GF, Kjellstrom T. Cadmium in the Environment, 2nd ed, CRC Press, Cleveland, 1974; pp 1-248.
2. Boscolo P, Carmignani M. Mechanisms of cardiovascular regulation in male rabbits chronically exposed to cadmium. Br J Ind Med 1986;43:605-610.
3. Sunderman FW Jr, Plowman MC, Hopfer SM. Embryotoxicity and teratogenicity of cadmium chloride in Xenopous laevis, assayed by the FETAX procedure. Ann Clin Lab Sci 1991;21:381-391.
4. Waalkes MP. Cadmium carcinogenesis. Mutat Res 2003;533:107-120.
5. Marth E, Barth SS, Jelovcan S. Influence of cadmium on the immune system. Description of stimulating reactions. Cent Eur J Public Health 2000;8:40-44.
6. Wang Y, Fang J, Leonard SS, Rao KM. Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 2004;36:1434-1443.
7. Szuster-Cielsielska A, Stachura A, Slotwinska A, Kaminska T, Sniezkl R, Paduch R, Abramczyk D, Filar J, Kandefer-Szerszen M. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species production in cell cultures. Toxicology 2000;145:159-171.
8. Brostoff J, Scadding GK, Male D, Roitt IM. Clinical Immunology. Gower Medical Pub, London, 1991.
9. Prasad AS. Zinc deficiency: its characterization and treatment. Metal Ions Biol Syst 2004;41:103-137.
10. Sunderman FW Jr. The influence of zinc on apoptosis. Ann Clin Lab Sci 1995;25:134-142.
11. Boscolo P, Di Gioacchino M, Sabbioni E, Benvenuti F, Conti P, Reale M, Gavazzano P, Giuliano G. Expression of lymphocyte subpopulations, cytokine serum levels and blood and urine trace elements in asymptomatic atopic men exposed to urban environment. Int Arch Occup Environ Health 1999;72:26-32.
12. Beattie JH, Bremmer I. Roles of metallothionein in cellular metabolism. In: Metals Ions in Biology and Medicine, (Collery P, Bratter P, Negretti de Bratter V, Khassanova L, Etienne JC, Eds), John Libbey, London, 1998; pp 117-127.
13. Petering DH, Huang M, Moteki S, Shaw CF III, Cadmium and lead interactions with transcription factor IIIA from Xenopus laevis: a model for zinc finger protein reaction with toxic metal ions and metallothionein. Environ Res 2000;50:89-92.
14. Neve J. Selenium as a "nutraceutical:" how to conciliate physiological supra-nutritional effects for an essential trace element. Curr Opin Clin Nutr Metab Care. 2002;5:659-663.
15. Combs GF Jr. Selenium and cancer, In: Antioxidants and Disease Prevention (Garewal H, Ed), CRC Press, New York, 1997; pp 97-113.
16. Suzuki KT, Sasakura C, Yoneda S. Binding sites for the (Hg-Se) complex on selenoprotein P. Biochim Biophys Acta 1998;1429:102-112.
17. Hawkes WC, Kelley DS, Taylor PC. The effects of dietary selenium on the immune system in healthy men. Biol Trace Elem Res 2001;81:189-213.
18. Borella P, Bargellini A, Solfrini V. Selenium interaction with human immune cell functions. In: Metals Ions in Biology and Medicine (Collery P, Bratter P, Negretti de Bratter V, Khassanova L, Etienne JC, Eds), John Libbey, London, 1998; pp 429-434.
19. Hartwig A, Blessing H, Schwerdtle T, Walter I. Modulation of DANN repair processes by arsenic and selenium compounds. Toxicology 2003;193:161-169
20. Male D, Cooke A, Owen M, Trowsdale J, Champion B. Advanced Immunology, Mosby, London, 1996.
21. Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 2000;182(Suppl 1):S62-S68.
22. Prasad AS, Bao B, Beck FW, Kukuk O, Sarkar FH. Antioxidant effect of zinc in humans. Free Radic Biol Med 2004;37:1182-1190.
23. Colombetti S, Benigni F, Basso V, Mondino A. Clonal anergy is mantained independently of T cell proliferation. J Immunol 2002;169:178-182.