Aciclovir protects against quinolinic-acid-induced oxidative neurotoxicity

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 7, 2005, Pages 883-888

  Muller A C ^a   Maharaj, H ^a   Maharaj, D S ^a   Daya, S ^a  

^a RHODES UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; QUINOLINIC ACID; REACTIVE OXYGEN METABOLITE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; CELL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; HERPES SIMPLEX ENCEPHALITIS; LIPID PEROXIDATION; MALE; MICROGLIA; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OPPORTUNISTIC INFECTION; RAT;

ACYCLOVIR; AIDS DEMENTIA COMPLEX; ANIMALS; ANTIVIRAL AGENTS; BRAIN; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; QUINOLINIC ACID; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 21044440264     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357056442     Document Type: Article

References (36)

1. Alexia, T., Borlongan, C. V., Faull, R. L. M., Williams, C. E., Clark, R. G., Gluckman, P. D., Hughes, P. E. (2000) Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases. Prog. Neurobiol. 60: 409-470
2. Belle', N. A. V., Duarte Dalmolin, G. D., Fonini, G., Rubin, M. A., Rocha, J. B. T. (2004) Polyamines reduce lipid peroxidation induced by different pro-oxidant agents. Brain Res. 1008: 245-251
3. Chen, S.-F., Huang, C.-C., Wu, H.-M., Chen, S.-H., Liang, Y.-C., Hsu, K.-S. (2004) Seizure, neuron loss, and mossy fiber sprouting in herpes simplex virus type 1-infected organotypic hippocampal cultures. Epilepsia 45: 322-332
4. ChinLim, M., Brooke, S. M., Sapolsky, R. M. (2003) gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. Brain Res. Bull. 61: 183-188
5. Choi, D. W. (1987) Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7: 369-379
6. Clifford, D. B. (2002) AIDS dementia. Med. Clin. North Am. 86: 537-550
7. Coyle, J. T., Puttfarcken, P. (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262: 689-695
8. Dawson, R., Flint Beal, M., Bondy, S. C., Di Monte, D. A., Isom, G. E. (1995) Excitotoxins, ageing, and environmental neurotoxins: implications for understanding human neurodegenerative diseases. Toxicol. Appl. Pharmacol. 134: 1-17
9. Erba, D., Riso, P., Criscuoli, F., Testolin, G. (2003) Malondialdehyde production in Jurkat T cells subjected to oxidative stress. Nutrition 19: 545-548
10. Flavin, M. P., Coughlin, K., Ho, L. T. (1997) Soluble macrophage factors trigger apoptosis in cultured hippocampal neurons. Neuroscience 80: 437-448
11. Garthwaite, G., Garthwaite, J. (1987) Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices. Neurosci. Lett. 79: 35-39
12. Gulliford, M. C., Chandrasekera, C. P., Cooper, R. A., Murphy, R. P. (1987) Acyclovir treatment of herpes simplex encephalitis: experiences in a district hospital. Postgrad. Med. J. 63: 1037-1041
13. Gunter, T. E., Gunter, K. K., Sheu, S.-S., Gavin, C. E. (1993) Mitochondrial calcium transport. Am. J. Physiol. 267: C313-C339
14. Heyes, M. P., Brew, B. J., Martin, A., Price, R. W., Salazar, A. M., Sidtis, J. J., Yergey, J. A., Mouradian, M. M., Sadler, A. E., Keilp, J. (1991) Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann. Neurol. 29: 202-209
15. Hopkins, K. J., Oster-Granite, M.-L. (1998) Characterization of N-methyl-D-aspartate receptors in the hyperammonemic Sparse fur mouse. Brain Res. 797: 209-217
16. Johnston, J. B., Zhang, K., Silva, C., Shalinsky, D. R., Conant, K., Ni, W., Corbett, D., Yong, V. W., Power, C. (2001) HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors. Ann. Neurol. 49: 230-241
17. König, J. F. R., Klippel, R. A. (1963) The rat brain. Williams & Wilkins, Baltimore, MD, pp 108-114
18. Lawrence, D. M., Major, E. O. (2002) Review: HIV-1 and the brain: connections between HIV-1 associated dementia, neuropathology and neuroimmunology. Microbes Infect. 4: 301-308
19. Lipton, S. A. (1998) Neuronal injury associated with HIV-1: approaches to treatment. Annu. Rev. Pharmacol. Toxicol. 38: 159-177
20. Lopez, O. L., Becker, J. T., Banks, G., Giconi, J., Sanchez, J., Dorst, S. K. (1996) Development of subtle neurological signs after systemic illness in HIV-infected individuals. Eur. Neurol. 36: 71-75
21. Monaghan, D. T., Cotman, C. W. (1986) Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes. Proc. Natl Acad. Sci. USA 83: 7532-7536
22. Mylonas, C., Kouretas, D. (1999) Lipid peroxidation and tissue damage. In Vivo 13: 295-309
23. Nath, A. (1999) Pathobiology of human immunodeficiency virus dementia. Semin. Neurol. 19: 113-127
24. O'Brien, J. J., Campoli-Richards, D. M. (1989) Acyclovir: an updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 37: 233-309
25. Ottino, P., Duncan, J. R. (1997) Effect of alpha-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells. Free Radic. Biol. Med. 22: 1145-1151
26. Pérez-Severiano, F., Rodríguez-Pérez, M., Pedraza-Chaverrí, J., Maldonado, P. D., Medina-Campos, O. N., Orttíz-Plata, A., Sánchez-García, A., Villeda- Hernández, J., Galván-Arzate, S., Aguilera, P., Santamaría, A. (2004) S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats. Neurochem Int. 45: 1175-1183
27. Pu, H., Tian, J., Flora, G., Woo Lee, Y., Nath, A., Hennig, B., Toborek, M. (2003) HIV-tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol. Cell. Neurosci. 24: 224-237
28. Reinhard, J. F. (1998) Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid. Neurochem. Res. 23: 661-665
29. Richards, D. M., Carmine, A. A., Brogden, R. N., Heel, R. C., Speight, T. M., Avery, G. S. (1983) Acyclovir: a review of its pharmacodynamic properties and therapeutic efficacy. Drugs 26: 378-438
30. Št'astný, F., Škultétyová, I., Pliss, L., Ježová, D. (2003) Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin. Brain Res. Bull. 53: 415-420
31. Streit, W. J., Walter, S. A., Pennell, N. A. (1999) Reactive microgliosis. Prog. Neurobiol. 57: 563-581
32. Tilson, H. A., Mundy, W. R. (1995) Bases of excitatory amino acid system-related neurotoxicity. In: Chang, L. W., Slikker, W. (eds) Neurotoxicology: approaches and methods. Academic Press, Inc., London, pp 359-370
33. Turchan, J., Pocernich, C. B., Gairola, C., Chauhan, A., Schiffito, G., Butterfield, D. A., Buch, S., Narayan, O., Sinai, A., Geiger, J., Berger, J. R., Elford, H., Nath, A. (2003) Oxidative stress in HIV-demented patients and protection ex vivo with novel antioxidants. Neurology 60: 307-314
34. Valle, M., Price, R. W., Nilsson, A., Heyes, M., Verotta, D. (2004) CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy. Brain 127: 1047-1060
35. Zar, J. H. (1974) Biostatistical analysis. Prentice Hall, Engelwood Cliffs, NJ, pp 151-466
36. Zielasek, J., Hartung, H. P. (1999) Molecular mechanisms of microglial activation. Adv. Neuroimmunol. 6: 122-191