Two different Alzheimer diseases in men and women: Clues from advanced neural networks and artificial intelligence

Gender Medicine

Volumn 2, Issue 2, 2005, Pages 106-117

  Grossi, Enzo ^a   Massini, Giulia ^b   Buscema, Massimo ^b   Savarè, Rita ^a   Maurelli, Guido ^b  

^a Bracco Imaging SpA   (Italy)

^b Semeion centro ricerche di scienze della communicazione   (Italy)

Author keywords

Alzheimer's; Clustering; Gender; Self organizing maps

Indexed keywords

DONEPEZIL; PLACEBO;

AGED; ALZHEIMER DISEASE; ARTICLE; ARTIFICIAL INTELLIGENCE; ARTIFICIAL NEURAL NETWORK; BEHAVIOR DISORDER; CLINICAL FEATURE; CLUSTER ANALYSIS; DEMENTIA; DEMOGRAPHY; DISABILITY; DISEASE SEVERITY; FEMALE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROPSYCHOLOGY; PRIORITY JOURNAL; SEX DIFFERENCE;

AGED; ALZHEIMER DISEASE; CLUSTER ANALYSIS; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; ITALY; MALE; NEURAL NETWORKS (COMPUTER); NONLINEAR DYNAMICS; SEX DISTRIBUTION; SEX FACTORS;

EID: 20944448793     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(05)80017-8     Document Type: Article

References (29)

1. Olivetti G. Giordano G. Corradi D. et al. Gender differences and aging: Effects on the human heart J Am Coll Cardiol 26 1995 1068-1079
2. Weissman M.M. Leaf P.J. Holzer C.E. III et al. The epidemiology of depression. An update of sex differences in rates J Affect Disord 7 1984 179-188
3. Hankin B.L. Abramson L.Y. Development of gender differences in depression: Description and possible explanations Ann Med 31 1999 372-379
4. Muck-Seler D. Pivac N. Jakovljevic M. Sex differences, season of birth and platelet 5-HT levels in schizophrenic patients J Neural Transm 106 1999 337-347
5. Nopoulos P. Flaum M. Andreasen N.C. Sex differences in brain morphology in schizophrenia Am J Psychiatry 154 1997 1648-1654
6. Stabile L.P. Siegfried J.M. Sex and gender differences in lung cancer J Gend Specif Med 6 2003 37-48
7. Barnes L.L. Wilson R.S. Bienias J.L. et al. Gender differences in the clinical manifestations of Alzheimer's disease pathology Neurobiol Aging 25 Suppl 2 2004 S314-S315 Abstract P2-289
8. Intebi A.D. Garau L. Brusco I. et al. Alzheimer's disease patients display gender dimorphism in circulating anorectic adipokines Neuroimmunomodulation 10 2002-2003 351-358
9. Colla M. Ende G. Bohrer M. et al. MR spectroscopy in Alzheimer's disease: Gender differences in probabilistic learning capacity Neurobiol Aging 24 2003 545-552
10. McPherson S. Back C. Buckwalter J.G. Cummings J.L. Gender-related cognitive deficits in Alzheimer's disease Int Psychogeriatr 11 1999 117-122
11. Muller-Thomsen T. Arlt S. Ganzer S. et al. Depression in Alzheimer's disease might be associated with apolipoprotein E ε4 allele frequency in women but not in men Dement Geriatr Cogn Disord 14 2002 59-63
12. Corder E.H. Ghebremedhin E. Taylor M.G. et al. The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distribu tions: Modification by age, sex, and APOE polymorphism Ann N Y Acad Sci 10 2004 24-28
13. Hayden K.M. Norton M.C. Tschanz J.T. et al. The complex role of cardiovascular risk factors, cerebrovascular disease, and gender, with the inci dence of Alzheimer's disease: Findings from theCache County study Neurobiol Aging 25 Suppl 2 2004 S388 Abstract P3-116
14. Kohonen T. Self-organized formation of topologically correct feature maps Biol Cybem 43 1982 59-69
15. Kohonen T. Learning vector quantization Neural Netw 1 (Suppl) 1988 303
16. Kohonen T. The self-organizing map Proc IEEE 78 1990 1464-1480
17. McKhann G. Drachman D. Folstein M. et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services TaskForce on Alzheimer's Disease Neurology 34 1984 939-944
18. Folstein M.F. Folstein S.E. McHugh P.R. "Minimental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189-198
19. Brazzelli M. Capitani E. Della Sala S. et al. A neuropsychologic instrument adding to the description of patients with suspected cortical dementia: The Milan overall dementia assessment J Neurol Neurosurg Psychiatry 57 1994 1510-1517
20. Novelli G. Papagno C. Capitani E. et al. Three clinical tests for the assessment of verbal long term memory function norms from 320 normal subjects Archivio di Psicologia Neurologia e Psichiatria 47 1986 278-296 [in Italian]
21. Benton A.L. Hamsher K. Multilingual Aphasia Examination 2nd ed. 1989 AJA Associates Iowa City, Iowa
22. Blessed G. Tomlinson B.E. Roth M. Blessed scale of dementia Brit J Psychiatr 111 1968 787-811
23. Ruitenberg A. Ott A. van Swieten J.C. et al. Incidence of dementia: Does gender make a difference? Neurobiol Aging 22 2001 575-580
24. Di Carlo A. Baldereschi M. Amaducci L. ILSA et al. Study Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy J Am Geriatr Soc 50 2002 41-48
25. Andersen K. Launer L.J. Dewey M.E. et al. EURODEM Incidence Research Group Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies Neurology 53 1999 1992-1997
26. Lapane K.L. Gambassi G. Landi F. et al. Gender differences in predictors of mortality in nursing home residents with AD Neurology 56 2001 650-654
27. Davis P.S. Holman C.D. Brameld K. Gender differences in survival of 234 patients referred to a psychogeriatric service Int J Geriatr Psychiatry 15 2000 1061-1069
28. Ott B.R. Lapane K.L. Gambassi G SAGE Study Group Systemic Assessment of Geriatric drug use via Epidemiology. Gender differences in the treatment of behavior problems in Alzheimer's disease Neurology 54 2000 427-432
29. Kiang M.Y. Kumar A. An evaluation of self-organizing map networks as a robust alternative to factor analysis in data mining applications Inf. Syst. Res. 2001 12 117-194