In silico modeling and simulation of bone biology: A proposal

Journal of Bone and Mineral Research

Volumn 20, Issue 7, 2005, Pages 1079-1084

  Defranoux, Nadine A ^a   Stokes, Cynthia L ^a   Young, Daniel L ^a   Kahn, Arnold J ^b  

^a Entelos Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone remodeling; Drug testing; In silico simulation; Mathematical modeling; Osteoporosis

Indexed keywords

BONE CELL; BONE MATRIX; BONE METABOLISM; BONE REMODELING; BONE STRUCTURE; BONE TISSUE; COMPUTER SIMULATION; HUMAN; MATHEMATICAL MODEL; MEDICAL RESEARCH; OSTEOBLAST; OSTEOCLAST; REVIEW;

BONE AND BONES; BONE DISEASES; BONE REMODELING; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL;

EID: 20844461165     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050401     Document Type: Review

References (13)

1. Helmick CG, Lawrence RC, Pollard RA, Lloyd E, Heyse SP 1995 Arthritis and other rheumatic conditions: Who is affected now, who will be affected later? Natl Arthr Data Workgroup Arthritis Care Res 8:203-211.
2. National Osteoporosis Foundation 2004 Osteoporosis: Fast facts. Available online at http://www.nof.org/osteoporosis/diseasefacts.htm. Accessed August 8, 2004.
3. Frost HM 1973 Bone Modeling and Skeletal Modeling Errors. Orthopedic Lectures, vol.1. C.C. Thomas, Springfield, IL, USA, p. 214.
4. Frost HM 1987 The mechanostat: A proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. Bone Miner 2:73-85.
5. Zippel H 1992 Julius Wolff and the law of bone remodelling. In: Regeling G (ed.) Wolff's Law and Connective Tissue Regulation. Walter de Gruyter, New York, NY, USA, pp. 1-12.
6. Turner CH 1999 Toward a mathematical description of bone biology: The principle of cellular accommodation. Calcif Tissue Int 65:466-471.
7. van der Linden JC, Birkenhager-Frenkel DH, Verhaar JA, Weinans H 2001 Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution. J Biomech 34:1573-1580.
8. Hernandez CJ, Beaupre GS, Carter DR 2003 A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of Osteoporosis. Osteoporos Int 14:843-847.
9. Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD 2000 Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature 405:704-706.
10. Lemaire V, Tobin FL, Greller LD, Cho CR, Suva LJ 2004 Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. J Theor Biol 229:293-309.
11. Paglia F, Dionisi S, De Geronimo S, Rosso R, Romagnoli E, Raejntroph N, Ragno A, Celi M, Pepe J, D'Erasmo E, Minisola S, Raejentroph N 2001 Biomarkers of bone turnover after a short period of steroid therapy in elderly men. Clin Chem 47:1314-1316.
12. Saag KG 2004 Prevention of glucocorticoid-induced osteoporosis. South Med J 97:555-558.
13. USA FDA 2004 Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products. Available online at http://www.fda.gov/ oc/initiatives/criticalpath/whitepaper.pdf. Accessed October 19, 2004.