The anti-depressant effect of Nelumbinis Semen on rats under chronic mild stress induced depression-like symptoms

American Journal of Chinese Medicine

Volumn 33, Issue 2, 2005, Pages 205-213

  Kang, Moonkyu ^a   Shin, Dongwon ^a   Oh, Jung Wan ^a   Cho, Chongwoon ^a   Lee, Hwa Jin ^a   Yoon, Dong Won ^a   Lee, Sang Moon ^a   Yun, Jung Hwan ^a   Choi, Hyun ^a   Park, Seongkyu ^a   Shin, Minkyu ^a   Hong, Moochang ^a   Bae, Hyunsu ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Anti depression effect; Chronic mild stress; Forced swim test; Nelumbinis Semen

Indexed keywords

CORNUS FRUIT; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; LYCIUM FRUIT; NELUMBINIS SEMEN; NEUROTRANSMITTER; PINELLIA RHIZOME; PLANT MEDICINAL PRODUCT; REHMANNIA RADIX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEPRESSION; DRUG MECHANISM; FORCED SWIMMING TEST; ILLUMINATION; LATENT PERIOD; MALE; NONHUMAN; RAT; STATISTICAL ANALYSIS; STRESS;

ANIMALS; DEPRESSION; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; LIGHT; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL;

EID: 20844460285     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05002874     Document Type: Article

References (28)

1. Gambarana, C., O. Ghiglieri, P. Tolu, M.G. De Montis, D. Giachetti, E. Bombardelli and A. Tagliamonte. Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats. Neuropsychopharmacology 21: 247-257, 1999.
2. Katz, R.J. Animal models and human depressive disorders. Neurosci. Biobehav. Rev. 5: 231-246, 1981.
3. Khalifa, A.E. Hypericum perforatum as a nootropic drug: Enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice. J. Ethnopharmacol. 76: 49-57, 2001.
4. Kulikov, A., J. Torresani and R. Jeanningros. Experimental hypothyroidism increases immobility in rats in the forced swim paradigm. Neurosci. Lett. 234: 111-114, 1997.
5. Li, G.R., X.G. Li and F.H. Lu. Effects of neferine on transmembrane potential in rabbit sinoatrial nodes and clusters of cultured myocardial cells from neonatal rats. Zhongguo Yao Li Xue Bao 10: 328-331, 1989a.
6. Li, G.R., X.G. Li and F.H. Lu. Effects of neferine on transmembrane potentials of guinea pig myocardium. Zhongguo Yao Li Xue Bao 10: 406-410, 1989b.
7. Li, G.R., J.Q. Qian and F.H. Lu. Effects of neferine on heart electromechanical activity in anaesthetized cats. Zhongguo Yao Li Xue Bao 11: 158-161, 1990.
8. Li, J.M. and L.D. Kong. Advances in the study on depression and anxiety treated with traditional Chinese medicine and herbal drugs. Zhongguo Zhong Yao Za Zhi 26: 805-807, 2001.
9. Lozoya, X., M. Meckes, M. Abou-Zaid, J. Tortoriello, C. Nozzolillo and J.T. Arnason. Quercetin glycosides in Psidium guajava L. leaves and determination of a spasmolytic principle. Arch. Med. Res. 25: 11-15, 1994.
10. Luo, L., J. Nong Wang, L.D. Kong, Q.G. Jiang and R.X. Tan. Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. J. Ethnopharmacol. 73: 277-281, 2000.
11. Monleon, S., P. D'Aquila, A. Parra, V.M. Simon, P.F. Brain and P. Willner. Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology (Berl. 117: 453-457, 1995.
12. Muscat, R., M. Papp and P. Willner. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl). 109: 433-438, 1992.
13. Nieto-Sampedro, M., D. Shelton and C.W. Cotman. Specific binding of kainic acid to purified subcellular fractions from rat brain. Neurochem. Res. 5: 591-604, 1980.
14. Pacher, P., E. Kohegyi, V. Kecskemeti and S. Furst. Current trends in the development of new antidepressants. Curr. Med. Chem. 8: 89-100, 2001.
15. Papp, M. and J. Wieronska. Antidepressant-like activity of amisulpride in two animal models of depression. J. Psychopharmacol. 14: 46-52, 2000.
16. Papp, M., P. Willner and R. Muscat. An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology (Berl). 104: 255-259, 1991.
17. Papp, M., P. Willner and R. Muscat. Behavioural sensitization to a dopamine agonist is associated with reversal of stress-induced anhedonia. Psychopharmacology (Berl). 110: 159-164, 1993.
18. Popoli, M., N. Brunello, J. Perez and G. Racagni. Second messenger-regulated protein kinases in the brain: Their functional role and the action of antidepressant drugs. J. Neurochem. 74: 21-33, 2000.
19. Sohn, D.H., Y.C. Kim, S.H. Oh, E.J. Park, X. Li and B.H. Lee. Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine 10: 165-169, 2003.
20. Wang, J., X. Hu, W. Yin and H. Cai. Alkaloids of plumula Nelumbinis. Zhongguo Zhong Yao Za Zhi 16:673-675, 703, 1991.
21. Willner, P. The validity of animal models of depression. Psychopharmacology (Berl). 83: 1-16, 1984.
22. Willner, P. Animal models as simulations of depression. Trends Pharmacol. Sci. 12: 131-136, 1991.
23. Willner, P. The mesolimbic dopamine system as a target for rapid antidepressant action. Int. Clin. Psychopharmacol. 12(Suppl. 3): S7-14, 1997a.
24. Willner, P. Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation. Psychopharmacology (Berl). 134: 319-329, 1997b.
25. Willner, P., J.L. Moreau, C.K. Nielsen, M. Papp and A. Sluzewska. Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight. Physiol. Behav. 60: 129-134, 1996.
26. Willner, P., A. Towell, D. Sampson, S. Sophokleous and R. Muscat. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 93: 358-364, 1987.
27. Woelk, H. Comparison of St John's wort and imipramine for treating depression: Randomised controlled trial. Br. Med. J. 321: 536-539, 2000.
28. Zelenski, S.G. Alkaloids of Nelumbo lutea (Wild.) pers. (Nymphaeaceae). J. Pharm. Sci. 66: 1627-1628, 1977.