Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivo 19F magnetic resonance spectroscopy

British Journal of Clinical Pharmacology

Volumn 59, Issue 2, 2005, Pages 244-248

  Payne, Geoffrey S ^a,e   Collins, David J ^a   Loynds, Peter ^b   Mould, Graham ^b   Murphy, Philip S ^a   Dzik Jurasz, Andrzej S K ^a   Kessar, Preminda ^a   Haque, Nazneen ^c   Yamaguchi, Masayuki ^d   Atarashi, Shogo ^d   Leach, Martin O ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Guildford Clinical Pharmacology Ltd   (United Kingdom)

^c Daiichi Pharmaceuticals   (United Kingdom)

^d DAIICHI SANKYO CO   (Japan)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

19F MRS; Antimicrobials; Pharmacokinetics; Sitafloxacin

Indexed keywords

ANTIINFECTIVE AGENT; SITAFLOXACIN;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG METABOLISM; HUMAN; HUMAN EXPERIMENT; LIVER METABOLISM; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; FLUOROQUINOLONES; HALF-LIFE; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE;

EID: 20844455753     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2004.02246.x     Document Type: Article

References (8)

1. Findlay M, Leach MO. In vivo monitoring of fluoropyrimidine metabolites. Magnetic resonance spectroscopy in the evaluation of 5-fluorouracil. Anti-Cancer Drugs 1994; 5: 260-80.
2. Findlay M, Leach MO, Cunningham D, Collins D, Payne GS, Glaholm J, Mansi J, McCready V. The non-invasive monitoring of low dose, infusional 5-fluorouracil and its modulaion by interferon-α using 19F magnetic resonance spectroscopy in patients with colorectal cancer: a pilot study. Ann Oncol 1993; 4: 597-602.
3. Presant C, Wolf W, Waluch V, Wiseman C, Kennedy P, Blayney D, Brechner R. Association of intratumoral pharmacokinetics of fluorouracil with clinical response. Lancet 1994; 343: 1184-75.
4. Jynge P, Skjetne T, Gribbestad I, Kleinbloesem C, Hoogkamer H, Antonsen O, Krane J, Bakoy O, Furuheim K, Nilsen O. In vivo tissue pharmacokinetics by fluorine magnetic resonance spectroscopy: a study of liver and muscle disposition of fleroxacin in humans. Clin Pharmacol Ther 1990; 48: 481-9.
5. O'Grady J, Briggs A, Atarashi S, Kobayashi H, Smith R, Ward J, Ward C, Milatovic D. Pharmacokinetics and absolute bioavailability of sitafloxacin, a new fluoroquinolone antibiotic, in healthy male and female Caucasian subjects. Xenobiotica 2001; 31: 811-22
6. Heid OH. Non-iterative localisized in vivo shimming in <15s. In Proceedings of the 4th Annual Meeting, International Society of Magnetic Resonance in Medicine, 1999; 363.
7. Snyder WS. Report of the Task Group on Reference Man. Pergamon Press, 1975.
8. 19F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil. Magnetic Resonance Med 2000; 44: 516-20.