메뉴 건너뛰기




Volumn 25, Issue 3, 2005, Pages 647-656

Chronic administration of aminoguanidine reduces vascular nitric oxide production and attenuates liver damage in bile duct-ligated rats

Author keywords

Activity; Aminoguanidine; Bile duct ligation; Liver cirrhosis; Nitric oxide; Nitric oxide synthase

Indexed keywords

AMINOGUANIDINE; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

EID: 20844449735     PISSN: 14783223     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2005.01063.x     Document Type: Article
Times cited : (21)

References (38)
  • 1
    • 0032948112 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase as a potential therapeutic target
    • Hobbs A J, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 1999; 39: 191-220.
    • (1999) Annu. Rev. Pharmacol. Toxicol. , vol.39 , pp. 191-220
    • Hobbs, A.J.1    Higgs, A.2    Moncada, S.3
  • 2
    • 0036154951 scopus 로고    scopus 로고
    • The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough
    • Wiest R, Groszmann R J. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 2002; 35: 478-91.
    • (2002) Hepatology , vol.35 , pp. 478-491
    • Wiest, R.1    Groszmann, R.J.2
  • 3
    • 0030248313 scopus 로고    scopus 로고
    • Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats
    • Cahill P A, Redmond E M, Hodges R, et al. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol 1996; 25: 370-8.
    • (1996) J. Hepatol. , vol.25 , pp. 370-378
    • Cahill, P.A.1    Redmond, E.M.2    Hodges, R.3
  • 4
    • 0027438813 scopus 로고
    • Increased serum nitrite and nitrate levels in patients with cirrhosis: Relationship to endotoxemia
    • Guarner C, Soriano G, Tomas A, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 1993; 18: 1139-43.
    • (1993) Hepatology , vol.18 , pp. 1139-1143
    • Guarner, C.1    Soriano, G.2    Tomas, A.3
  • 5
    • 0031737665 scopus 로고    scopus 로고
    • Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats
    • Hori N, Wiest R, Groszmann R J. Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats. Hepatology 1998; 28: 1467-73.
    • (1998) Hepatology , vol.28 , pp. 1467-1473
    • Hori, N.1    Wiest, R.2    Groszmann, R.J.3
  • 6
    • 0029965368 scopus 로고    scopus 로고
    • Upregulation of endothelial constitutive NOS: A major role in the increased NO production in cirrhotic rats
    • Martin P Y, Xu D L. Niederberger M, et al. Upregulation of endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996; 270: F494-9.
    • (1996) Am. J. Physiol. , vol.270
    • Martin, P.Y.1    Xu, D.L.2    Niederberger, M.3
  • 7
    • 0028829527 scopus 로고
    • Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats
    • Niederberger M, Martin P Y, Gines P, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995; 109: 1624-30.
    • (1995) Gastroenterology , vol.109 , pp. 1624-1630
    • Niederberger, M.1    Martin, P.Y.2    Gines, P.3
  • 8
    • 0028905429 scopus 로고
    • Nitric oxide production in arterial vessels of cirrhotic rats
    • Ros J, Jimenez W, Lamas S, et al. Nitric oxide production in arterial vessels of cirrhotic rats. Hepatology 1995; 21: 554-60.
    • (1995) Hepatology , vol.21 , pp. 554-560
    • Ros, J.1    Jimenez, W.2    Lamas, S.3
  • 9
    • 0036749813 scopus 로고    scopus 로고
    • Differential expression and localization of nitric oxide synthases in cirrhotic livers of bile duct-ligated rats
    • Wei C L, Khoo H E, Lee K H, Hon W M. Differential expression and localization of nitric oxide synthases in cirrhotic livers of bile duct-ligated rats. Nitric Oxide 2002; 7: 91-102.
    • (2002) Nitric Oxide , vol.7 , pp. 91-102
    • Wei, C.L.1    Khoo, H.E.2    Lee, K.H.3    Hon, W.M.4
  • 10
    • 0031941122 scopus 로고    scopus 로고
    • Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension
    • Rockey D C, Chung J J. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998; 114: 344-51.
    • (1998) Gastroenterology , vol.114 , pp. 344-351
    • Rockey, D.C.1    Chung, J.J.2
  • 11
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
    • Shah V, Toruner M, Haddad F, et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999; 117: 1222-8.
    • (1999) Gastroenterology , vol.117 , pp. 1222-1228
    • Shah, V.1    Toruner, M.2    Haddad, F.3
  • 13
    • 0029043176 scopus 로고
    • Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: Evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis
    • Niederberger M, Gines P, Tsai P, et al. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 1995; 21: 1625-31.
    • (1995) Hepatology , vol.21 , pp. 1625-1631
    • Niederberger, M.1    Gines, P.2    Tsai, P.3
  • 14
    • 0027402115 scopus 로고
    • Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
    • Misko T P, Moore W M, Kasten T P, et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993; 233: 119-25.
    • (1993) Eur. J. Pharmacol. , vol.233 , pp. 119-125
    • Misko, T.P.1    Moore, W.M.2    Kasten, T.P.3
  • 15
    • 33750851120 scopus 로고    scopus 로고
    • Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia
    • Hock C E, Yin K, Yue G, Wong P Y. Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia. Am J Physiol 1997; 272: H843-50.
    • (1997) Am. J. Physiol. , vol.272
    • Hock, C.E.1    Yin, K.2    Yue, G.3    Wong, P.Y.4
  • 16
    • 0342378148 scopus 로고    scopus 로고
    • Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon
    • Laszlo F, Whittle B J. Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. Eur J Pharmacol 1997; 334: 99-102.
    • (1997) Eur. J. Pharmacol. , vol.334 , pp. 99-102
    • Laszlo, F.1    Whittle, B.J.2
  • 17
    • 0031183178 scopus 로고    scopus 로고
    • Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-N6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin
    • Ridger V C, Pettipher E R, Bryant C E, Brain S D. Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-N6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin. J Immunol 1997; 159: 383-90.
    • (1997) J. Immunol. , vol.159 , pp. 383-390
    • Ridger, V.C.1    Pettipher, E.R.2    Bryant, C.E.3    Brain, S.D.4
  • 18
    • 0028911559 scopus 로고
    • Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock
    • Wu C C, Chen S J, Szabo C, et al. Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br J Pharmacol 1995; 114: 1666-72.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 1666-1672
    • Wu, C.C.1    Chen, S.J.2    Szabo, C.3
  • 19
    • 0037371658 scopus 로고    scopus 로고
    • Expression of haemoxygenase in cirrhotic rat liver
    • Wei C L, Lee K H, Khoo H E, Hon W M. Expression of haemoxygenase in cirrhotic rat liver. J Pathol 2003; 199: 324-34.
    • (2003) J. Pathol. , vol.199 , pp. 324-334
    • Wei, C.L.1    Lee, K.H.2    Khoo, H.E.3    Hon, W.M.4
  • 20
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-9.
    • (1995) J. Hepatol. , vol.22 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 21
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • Knodell R G, Ishak K G, Black W C, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-5.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3
  • 22
    • 12344314054 scopus 로고    scopus 로고
    • Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis
    • Wei C L, Hon W M, Lee K H, Khoo H E. Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis. World J Gastroenterol 2005; 11: 362-7.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 362-367
    • Wei, C.L.1    Hon, W.M.2    Lee, K.H.3    Khoo, H.E.4
  • 23
    • 0026504731 scopus 로고
    • Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension
    • Pizcueta M P, Pique J M, Bosch J, et al. Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. Br J Pharmacol 1992; 105: 184-90.
    • (1992) Br. J. Pharmacol. , vol.105 , pp. 184-190
    • Pizcueta, M.P.1    Pique, J.M.2    Bosch, J.3
  • 24
    • 0029887795 scopus 로고    scopus 로고
    • Role of NO in the pulmonary artery hyporeactivity to phenylephrine in experimental biliary cirrhosis
    • Chabot F, Mestiri H, Sabry S, et al. Role of NO in the pulmonary artery hyporeactivity to phenylephrine in experimental biliary cirrhosis. Eur Respir J 1996; 9: 560-4.
    • (1996) Eur. Respir. J. , vol.9 , pp. 560-564
    • Chabot, F.1    Mestiri, H.2    Sabry, S.3
  • 25
    • 0029080711 scopus 로고
    • Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis
    • Ros J, Claria J, Jimenez W, et al. Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis. Hepatology 1995; 22: 915-20.
    • (1995) Hepatology , vol.22 , pp. 915-920
    • Ros, J.1    Claria, J.2    Jimenez, W.3
  • 26
    • 0029868838 scopus 로고    scopus 로고
    • Dose-dependent effects of a nitric oxide biosynthesis inhibitor on hyperdynamic circulation in two models of portal hypertension in conscious rats
    • Pilette C, Kirstetter P, Sogni P, et al. Dose-dependent effects of a nitric oxide biosynthesis inhibitor on hyperdynamic circulation in two models of portal hypertension in conscious rats. J Gastroenterol Hepatol 1996; 11: 1-6.
    • (1996) J. Gastroenterol. Hepatol. , vol.11 , pp. 1-6
    • Pilette, C.1    Kirstetter, P.2    Sogni, P.3
  • 27
    • 0030829599 scopus 로고    scopus 로고
    • Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats
    • Vos T A, Gouw A S, Klok P A, et al. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology 1997; 113: 1323-33.
    • (1997) Gastroenterology , vol.113 , pp. 1323-1333
    • Vos, T.A.1    Gouw, A.S.2    Klok, P.A.3
  • 28
    • 0040076226 scopus 로고    scopus 로고
    • Does upregulation of inducible nitric oxide synthase play a role in hepatic injury?
    • Liu T H, Robinson E K, Helmer K S, et al. Does upregulation of inducible nitric oxide synthase play a role in hepatic injury? Shock 2002; 18: 549-54.
    • (2002) Shock , vol.18 , pp. 549-554
    • Liu, T.H.1    Robinson, E.K.2    Helmer, K.S.3
  • 29
    • 0026641944 scopus 로고
    • Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction
    • Corbett J A, Tilton R G, Chang K, et al. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 1992; 41: 552-6.
    • (1992) Diabetes , vol.41 , pp. 552-556
    • Corbett, J.A.1    Tilton, R.G.2    Chang, K.3
  • 30
    • 0033773190 scopus 로고    scopus 로고
    • Role of nitric oxide and endothelin-1 in a portal hypertensive rat model
    • Tsugawa K, Hashizume M, Migou S, et al. Role of nitric oxide and endothelin-1 in a portal hypertensive rat model. Scand J Gastroenterol 2000; 35: 1097-105.
    • (2000) Scand. J. Gastroenterol. , vol.35 , pp. 1097-1105
    • Tsugawa, K.1    Hashizume, M.2    Migou, S.3
  • 31
    • 0020581239 scopus 로고
    • Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism
    • Bieganski T, Kusche J, Lorenz W, et al. Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism. Biochem Biophys Acta 1983; 756: 196-203.
    • (1983) Biochem. Biophys. Acta , vol.756 , pp. 196-203
    • Bieganski, T.1    Kusche, J.2    Lorenz, W.3
  • 32
    • 0021920139 scopus 로고
    • The influence of catabolic reactions on polyamine excretion
    • Seiler N, Bolkenius F N, Knodgen B. The influence of catabolic reactions on polyamine excretion. Biochem J 1985; 225: 219-26.
    • (1985) Biochem. J. , vol.225 , pp. 219-226
    • Seiler, N.1    Bolkenius, F.N.2    Knodgen, B.3
  • 33
    • 0027517899 scopus 로고
    • Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro
    • Ou P, Wolff S P. Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro. Biochem Pharmacol 1993; 46: 1139-44.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1139-1144
    • Ou, P.1    Wolff, S.P.2
  • 34
    • 0026625832 scopus 로고
    • Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors
    • Picard S, Parthasarathy S, Fruebis J, Witztum J L. Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors. Proc Natl Acad Sci USA 1992; 89: 6876-80.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6876-6880
    • Picard, S.1    Parthasarathy, S.2    Fruebis, J.3    Witztum, J.L.4
  • 35
    • 0035902558 scopus 로고    scopus 로고
    • NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
    • Fiorucci S, Antonelli E, Morelli O, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci USA 2001; 98: 8897-902.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8897-8902
    • Fiorucci, S.1    Antonelli, E.2    Morelli, O.3
  • 36
    • 0036789335 scopus 로고    scopus 로고
    • Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats
    • Moal F, Chappard D, Wang J, et al. Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats. Hepatology 2002; 36: 840-9.
    • (2002) Hepatology , vol.36 , pp. 840-849
    • Moal, F.1    Chappard, D.2    Wang, J.3
  • 37
    • 0034121518 scopus 로고    scopus 로고
    • Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension
    • Yu Q, Shao R, Qian H S, et al. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J Clin Invest 2000; 105: 741-8.
    • (2000) J. Clin. Invest. , vol.105 , pp. 741-748
    • Yu, Q.1    Shao, R.2    Qian, H.S.3
  • 38
    • 0036719232 scopus 로고    scopus 로고
    • In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
    • Van De C M, Omasta A, Janssens S, et al. In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats. Gut 2002; 51: 440-5.
    • (2002) Gut , vol.51 , pp. 440-445
    • Van De, C.M.1    Omasta, A.2    Janssens, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.