Toxicity assessment of montmorillonite as a drug carrier for pharmaceutical applications: Yeast and rats model

Biomedical Engineering - Applications, Basis and Communications

Volumn 17, Issue 2, 2005, Pages 72-78

  Lee, Yuan Haun ^a   Kuo, Tzong Fu ^a   Chen, Bor Yann ^b   Feng, Yi Kai ^a   Wen, Yu Ren ^a   Lin, Wu Ching ^a   Lin, F H ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL ILAN UNIVERSITY   (Taiwan)

Author keywords

Dose response analysis; Drug carrier; Montmorillonite; Probit model; acute toxicological tests; Saccharomyces cerevisiae

Indexed keywords

BIOCHEMISTRY; CALCIUM; DRUG THERAPY; HEMOGLOBIN; PATHOLOGY; PLASMAS; STATISTICAL METHODS; TOXICITY; TUMORS; YEAST;

ANTICANCER DRUGS; DOSE-RESPONSE ANALYSIS; MONTMORILLONITE; PLASMA CALCIUM;

DRUG PRODUCTS;

CALCIUM; CHLORIDE; DRUG CARRIER; FLUOROURACIL; HEMOGLOBIN; METHOMYL; MONTMORILLONITE; PHOSPHATE BUFFERED SALINE; POTASSIUM; POTASSIUM FERRICYANIDE; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; CALCIUM BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SAFETY; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HEMOGLOBIN DETERMINATION; LEUKOCYTE; LEUKOCYTE COUNT; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NONHUMAN; POTASSIUM BLOOD LEVEL; RAT; SACCHAROMYCES CEREVISIAE; SODIUM BLOOD LEVEL; TOXICITY;

ANIMALIA; RATTUS NORVEGICUS; SACCHAROMYCES CEREVISIAE;

EID: 20744440812     PISSN: 10162372     EISSN: None     Source Type: Journal    
DOI: 10.4015/S1016237205000111     Document Type: Article

References (13)

1. Ralph E. Grim, Clay Mineralogy, 2nd ed., McGraw-Hill, New York, p39-41 (1968)
2. Feng-Hui Lin, Yuan-Haun Lee, Ci-Heng Jian, Jau-Min Wong, Ming-Jium Shieh, Cheng-Yi Wang, "A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier." Biomaterials 23: 1981-1987 (2002).
3. Yin-Jie Cheng, Pillared Montmorillonite Intercalated with Sulfasalazine as Drug Carrier for Inflammatory Bowel Disease Treatment, Department of Materials Science and Engineering, National Taiwan University, Master Thesis, June 2002.
4. N. J. Meropol, P. J. Creaven, N. J. Petrelli, "Metastatic colorectal cancer: advances in biochemical modulation and new drug development." Seminar Oncology, 22: 509-524 (1995).
5. B.-Y. Chen, H.L. Liu, Y.W. Chen, Y.C. Cheng, "Dose-response assessment of metal toxicity upon indigenous Thiobacillus thiooxidans BC1." Process Biochemistry 39: 735-745 (2004).
6. Connell, D.; Lam, P.; Richardson, B.; Wu, R. Chapter 6: Dose and Concentration Response Relationships. In: Introduction to Ecotoxicology, Blackwell Sc. Ltd., 1999.
7. Ottoboni, M.-A. Chapter 8 Chronic toxicity. In: The Dose makes the Poison, 2nd Ed. Int' 1 Thomson Pub. New York, 1997.
8. Rodricks, J.-V. Chapter 9 Dose and Response. In: Calculated Risks. Pp. 158-179, Univ. Press Cambridge, 1992.
9. Pirt, S.J. Principles of Microbial and Cell Cultivation. A Halsted Press Book. John Wiley & Sons, New York.
10. Schoenhard, D. E. Unit V. Growth of Bacteria. In: Basic Concepts and Experiments in Microbiology.
11. Finney, D. J. Probit analysis. London: Cambridge Univ. Press, 1971.
12. Xing-Lin Tsai, "The study on montmorillonite for the mechanism of growth inhibition in microorganism." Master thesis, National Taiwan University (2000).
13. Tian You Ding, "Studies on the electrochemistry of montmorillonite in relation with the growth inhibition in microorganism." Master thesis, National Taiwan University (2000).