The ubiquitin-proteasome pathway: Limitations and opportunities

Journal of Supportive Oncology

Volumn 3, Issue 3, 2005, Pages 221-222

  Attaix, Didier ^a   Ventadour, Sophie ^a   Taillandier, Daniel ^a   Combaret, Lydie ^a  

^a Ctr Rech Nutr Hum Clermont F   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYSTEMUSTINE; CYTOKINE; FREE RADICAL; GLUCOCORTICOID; IFOSFAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUSCLE PROTEIN; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3;

ADENOCARCINOMA; CACHEXIA; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CATABOLISM; DISEASE MODEL; DOWN REGULATION; DRUG MECHANISM; HUMAN; MORBIDITY; MUSCLE ATROPHY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN FUNCTION; QUALITY OF LIFE; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

BLOOD PROTEINS; CYTOKINES; GLUCOCORTICOIDS; HUMANS; MUSCLE PROTEINS; MUSCULAR ATROPHY; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; UBIQUITINS;

EID: 20744432494     PISSN: 15446794     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (6)

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2. Mitch WE, Goldberg AL. Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway. N Engl J Med 1996;335:1897-1905.
3. Wei W, Fareed MU, Evenson A, et al. Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. Am J Physiol Regul Integr Comp Physiol 2005;288:R580-R590.
4. Lecker SH, Jagoe RT, Gilbert A, et al. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J 2004;18:39-51.
5. Cai D, Frantz JD, Tawa NE Jr, et al. IKKβ/NF-κB activation causes severe muscle wasting in mice. Cell 2004;119:285-298.
6. Tilignac T, Temparis S, Combaret L, et al. Chemotherapy inhibits skeletal muscle ubiquitin-proteasome-dependent proteolysis. Cancer Res 2002;62:2771-2777.