Wilms' tumor management

Current Opinion in Urology

Volumn 15, Issue 4, 2005, Pages 273-276

  Wu, Hsi Yang ^a   Snyder III, Howard M ^b   D'Angio, Giulio J ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Diagnosis; Nephroblastoma; Therapeutics; Treatment; Wilms' tumor

Indexed keywords

ANTINEOPLASTIC AGENT; DACTINOMYCIN; DOXORUBICIN; VINCRISTINE;

ANIRIDIA; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CLEAR CELL SARCOMA; HUMAN; KIDNEY FAILURE; MENTAL RETARDATION MALFORMATION SYNDROME; NEPHRECTOMY; NEPHROBLASTOMA; PARTIAL NEPHRECTOMY; PATIENT SELECTION; PEDIATRIC SURGERY; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; WAGR SYNDROME;

EID: 20644466426     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mou.0000172403.69890.eb     Document Type: Review

References (19)

1. Tournade MF, Com-Nougue C, Voute PA, et al. Results of the Sixth International Society of Paediatric Oncology Wilms' Tumor Trial and Study: A risk adapted therapeutic approach in Wilms tumor. J Clin Oncol 1993; 11:1012-1023.
2. Jereb B, Burgers MV, Tournade MF, et al. Radiotherapy in the SIOP (International Society of Paediatric Oncology) nephroblastoma studies: A review. Med Pediatr Oncol 1994; 22:221-227.
3. Lemerle J, Voute PA, Tournade MF, et al. Effectiveness of pre-operative chemotherapy in Wilms timor: Results of an International Society of Paediatric Oncology (SIOP) clinical trial. J Clin Oncol 1983; 10:604-609.
4. D'Angio GJ. Pre- or post-operative treatment for Wilms Tumor? Who, what, when, where, how, why - and which. Med Pediatr Oncol 2003; 41:545-549.
5. Tournade MF, Com-Nougue C, de Kraker J, et al. Optimal duration of preoperative therapy in unilateral and nonmetastatic Wilms' tumor in children older than 6 months: results of the Ninth International Society of Pediatric Oncology Wilms' Tumor Trial and Study. J Clin Oncol 2001; 19:488-500.
6. Vujanic Gm, Kelsey A, Mitchell C, et al. The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3. Med Pediatr Oncol 2003; 40:18-22.
7. Ritchey ML, Green DM, Breslow NB, et al. Accuracy of current imaging modalities in the diagnosis of synchronous bilateral Wilms' tumor. Cancer 1995; 75:600-604.
8. Ritchey ML, Shamberger RC, Hamilton T, et al. Fate of bilateral lesions missed on preoperative imaging: A report from the National Wilms Tumor Study Group. In: Program for Scientific Sessions, American Academy of Pediatrics 2004 National Conference and Exhibition, Section on Urology; 8-11 October 2004; San Francisco. Elk Grove Village: American Academy of Pediatrics; 2004. p. 51. The change to staging the contralateral kidney using imaging alone represents the success of current chemotherapeutic regimens.
9. Ritchey ML. Editorial comment to partial nephrectomy for unilateral Wilms' tumor. J Urol 2003; 170:943.
10. Haecker FM, von Schweinitz D, Harms D, et al. Partial nephrectomy for unilateral Wilms' tumor. J Urol 2003; 170:939-944.
11. Ritchey ML, Godzinski J, Shamberger RC, et al. Surgical complications following nephrectomy for Wilms' tumor: a prospective study from the National Wilms Tumor Study Goup (NWTSG) and International Society of Pediatric Oncology (SIOP). In: Program for Scientific Sessions, American Academy of Pediatrics 2004 National Conference and Exhibition, Section on Urology; 8-11 October 2004; San Francisco. Elk Grove Village: American Academy of Pediatrics; 2004. p. 55.
12. Breslow NE, Ou SS, Beckwith JB, et al. Doxorubicin for favorable histology. Stage H-III Wilms tumor. Cancer 2004; 101:1072-1080. Doxorubicin improves recurrence-free survival in stage III tumors, but factoring in the use of radiotherapy for these patients resulted in no significant improvement in overall survival. An important point which is not emphasized is that there is no long term risk of congestive heart failure with the lower dose of doxorubicin currently used.
13. de Kraker J, Graf N, van Tinteren H, et al. Reduction of postoperative chemotherapy in children with stage I intermediate-risk and anaplastic Wilms' tumour (SIOP 93-01 trial): a randomized controlled trial. Lancet 2004; 364:1229-1235. A shorter postoperative course of chemotherapy in stage I tumors is bringing the SIOP and NWTS approaches closer together. It remains clear that all patients with stage I tumors still require some form of chemotherapy, although the optimal duration and whether to use one or two drugs is still being studied.
14. Reinhard H, Semler O, Burger D, et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral nonmetastatic Wilms' tumor. Klinische Padiatrie 2004; 216:132-140.
15. Pritchard-Jones K, Kelsey A, Vujanic G, et al. Older age is an adverse prognostic factor in Stage I, favorable histology Wilms' tumor treated with vincristine monotherapy: a study by the United Kingdom Children's Cancer Study Group, Wilms' Tumor Working Group. J Clin Oncol 2003; 21:3269-3275.
16. Kalapurakal JA, Li SM, Breslow NE, et al. Influence on radiation therapy delay on abdominal tumor recurrence in patients with favorable histology Wilms' tumor treated on NWTS-3 and NWTS-4: a report from the National Wilms' Tumor Study Group. Int J Radiation Oncology Biol Phys 2003; 57:495-499.
17. Grundy RG, Hutton C, Middleton H, et al. Outcome of patients with Stage III or inoperable WT treated on the second United Kingdom WT protocol (UKWT2); a United Kingdom Children's Cancer Study Group (UKCCSG). Pediatr Blood Cancer 2004; 42:311-319.
18. Seibel NL, Li S, Breslow NE, et al. Effect of duration of treatment on treatment outcome for patients with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study Group. J Clin Oncol 2004; 22:468-473. Longer chemotherapy appears to be beneficial without increasing the risk of long term complications.
19. Breslow NE, Norris R, Norkool PA, et al. Characteristics and outcomes of children with the Wilms' tumor-Aniridia syndrome: a report from the National Wilms Tumor Study Group. J Clin Oncol 2004; 21:4579-4585. The outcomes of patients with Wifms' tumor in the context of syndromes like WAGR are unexpectedly poor despite better histology and earlier presentation. Although these patients have deletions in WT1, how this is linked to renal failure is still unclear.