Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion

European Journal of Anaesthesiology

Volumn 22, Issue 1, 2005, Pages 49-55

  Gozal, Yaacov ^a   Chevion, M ^a   Elami, A ^a   Berenshtein, E ^a   Kitrossky, N ^a   Drenger, B ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Anaesthetics inhalation, isoflurane; Chelating agents, zinc, desferrioxamine; Ischaemic preconditioning, myocardial; Myocardial reperfusion injury

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; DEFEROXAMINE; HYDROXYL RADICAL; ISOFLURANE; LACTIC ACID; OXYGEN; SALICYLIC ACID; ZINC; 2,3 DIHYDROXY BENZOIC ACID; 2,3-DIHYDROXY BENZOIC ACID; ANTIDOTE; CATECHOL DERIVATIVE; DIAGNOSTIC AGENT; INHALATION ANESTHETIC AGENT; SALICYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BLOOD PH; CONTROLLED STUDY; CORONARY SINUS; DOG; DRUG BLOOD LEVEL; HEART INFARCTION PREVENTION; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VIVO STUDY; LACTATE BLOOD LEVEL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; OXYGEN BLOOD LEVEL; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; HEART MUSCLE; HEART RATE; METABOLISM; OXYGEN CONSUMPTION; PH; REPERFUSION INJURY;

ANESTHETICS, INHALATION; ANIMALS; ANTIDOTES; BLOOD PRESSURE; CATECHOLS; DEFEROXAMINE; DOGS; HEART RATE; HYDROGEN-ION CONCENTRATION; HYDROXYL RADICAL; ISCHEMIC PRECONDITIONING, MYOCARDIAL; ISOFLURANE; LACTIC ACID; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXYGEN CONSUMPTION; SALICYLATES;

EID: 20644444586     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021505000116     Document Type: Article

References (25)

1. Warltier DC, Al-Wathiqui MH, Kampine JP, Schmeling WT. Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane. Anesthesiology 1988; 69: 552-565.
2. Marijic J, Stowe DF, Turner LA, et al. Differential protective effects of halothane and isoflurane against hypoxia and reoxygenation injury in the isolated guinea pig heart. Anesthesiology 1990; 73: 976-983.
3. Luss H, Meissner A, Rolf N, et al. Biochemical mechanism(s) of stunning in conscious dogs. Am J Physiol 2000; 279: H176-H184.
4. Kanaya N, Kobayashi I, Nakayama M, et al. ATP sparing effect of isoflurane during ischaemia and reperfusion of the canine heart. Br J Anaesth 1995; 74: 563-568.
5. Kanaya N, Fujita S. The effects of isoflurane on regional myocardial contractility and metabolism in 'stunned' myocardium in acutely instrumented dogs. Anesth Analg 1994; 79: 447-454.
6. Kersten JR, Orth KG, Pagel PS, et al. Role of adenosine in isoflurane-induced cardioprotection. Anesthesiology 1997; 86: 1128-1139.
7. ATP channel antagonist, attenuates the cardioprotective effects of isoflurane in stunned myocardium. Anesth Analg 1996; 83: 27-33.
8. ATP) channels. Anesthesiology 1996; 85: 794-807.
9. ATP channels. Anesthesiology 1997; 87: 361-370.
10. Chevion M, Jiang Y, Har-El R, et al. Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury. Proc Nat Acad Sci 1993; 90: 1102-1106.
11. Chevion M. A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals. Free Radic Biol Med 1988; 5: 27-37.
12. Chevion M. Protection against free radical-induced and transition metal-mediated damage: the use of 'pull' and 'push' mechanisms. Free Radic Res Comms 1991; 12-13: 691-696.
13. Karwatowska-Prokopczuk E, Czarnowska E, Beresewicz A. Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart. Cardiovasc Res 1992; 26: 58-66.
14. Samuni AM, Afeworki M, Stein W, et al. Multifunctional antioxidant activity of HBED iron chelator. Free Radic Biol Med 2001; 30: 170-177.
15. Berenshtein E, Vaisman B, Goldberg-Langerman C, et al. Roles of ferritin and iron in ischemic preconditioning of the heart. Mol Cell Biochem 2002; 234-235: 283-292.
16. Floyd RA, Henderson R, Watson JJ, Wong PK. Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats. Free Radic Biol Med 1986; 2: 13-18.
17. Onodera T, Ashraf M. Detection of hydroxyl radicals in the post-ischemic reperfused heart using salicylate as a trapping agent. J Mol Cell Cardiol 1991; 23: 365-370.
18. Halliwell B, Kaur H, Ingelman-Sundberg M. Hydroxylation of salicylate as an assay for hydroxyl radicals: a cautionary note. Free Radic Biol Med 1991; 10: 439-441.
19. Glantz L, Ginosar Y, Chevion M, et al. Halothane prevents postischemic production of hydroxyl radicals in the canine heart. Anesthesiology 1997; 86: 440-447.
20. Simpson PJ, Lucchesi BR. Free radicals and myocardial ischemia and reperfusion injury. J Lab Clin Med 1987; 110: 13-30.
21. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989; 80: 1049-1062.
22. ATP channels triggers the preconditioned state by generating free radicals. Circ Res 2000; 87: 460-466.
23. Bolli R, Patel BS, Zhu WX, et al. The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction. Am J Physiol 1987; 253: H1372-H1380.
24. Karck M, Tanaka S, Berenshtein E, et al. The 'push-pull' mechanism to scavenge redox active transition metals: a novel concept in myocardial protection. J Thorac Cardiovasc Surg 2001; 121: 1169-1178.
25. Kashimoto S, Kume M, Ikeya K, Kumazawa T. Effects of sevoflurane and isoflurane in the post-ischaemic reperfused heart. Eur J Anaesthesiol 1998; 15: 553-558.