Association of genetic polymorphisms in plasminogen activator inhibitor-1 gene and 5, 10-methylenetetrahydrofolate reductase gene with recurrent early spontaneous abortion

Chinese Journal of Medical Genetics

Volumn 22, Issue 3, 2005, Pages 330-333

  Guan, Li Xue ^a   Du, Xin Ying ^a   Wang, Jing Xian ^a   Gao, Li ^a   Wang, Rui Li ^a   Li, Hai Bo ^a   Wang, Shou Xun ^b  

^a WEIFANG PEOPLE'S HOSPITAL   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Genetic polymorphism; Methylenetetrahydrofolate reductase; Plasminogen activator inhibitor 1; Recurrent early spontaneous abortion

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADULT; ARTICLE; CONTROLLED STUDY; ECLAMPSIA; FEMALE; FIRST TRIMESTER PREGNANCY; GENE DOSAGE; GENE FREQUENCY; GENETIC POLYMORPHISM; HIGH RISK PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREGNANCY COMPLICATION; PREMATURITY; RECURRENT ABORTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPONTANEOUS ABORTION; STILLBIRTH;

ABORTION, HABITUAL; ADULT; ALLELES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREGNANCY; YOUNG ADULT;

EID: 20644436037     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Richards EM, Makri SM, Preston FE. The successful use of protein C concentrate during pregnancy in a patient with type 1 protein C deficiency, previous thrombosis and recurrent fetal loss. Br J Haematol, 1997, 98:660-661.
2. Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood, 2000, 95:1517-1532.
3. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995, 10:111-113.
4. Guan LX, Ji XW, Wang JX, et al. Association of plasminogen activitor inhibitor-1 gene 4G/5G polymorphism and coronary heart disease in Chinese patients. Chin J Med Genet, 2002, 19:393-396.
5. Qiu L, Yan SK, Song YH. Methylenetetrahydrofolate reductase gene polymorphism and deep-vein thrombosis. Chin J Lab Med, 2002, 25:200-203.
6. Iwai N, Shimoike H, Nakamura Y, et al. The 4G/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of progression to acute coronary syndromes. Atherosclerosis, 1998, 136:109-114.
7. Glueck CJ, Phillips H, Cameron D, et al. The 4G/5G polymorphism of the hypofibrinolytic plasminogen activator inhibitor type 1 gene: an independent risk factor for serious pregnancy complications. Metabolism, 2000, 49:845-852
8. Gao MY. The changes of plasminogen activitor inhibitor type 1 thrombin anti-thrombin III complex and D dimmer in patients with preeclampsia. Chin J Perinat, 2000, 3:131-134.
9. Ogasawara M, Aoki K, Okada S, et al. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril, 2000, 73:300-304.
10. Nelen WL, Blom HJ, Steegers EA, et al. Homocysteine and folate levels as risk factors for recurrent early spontaneous abortion. Obstet Gynecol, 2000, 95:519-523.
11. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr, 2000, 71:1295-1303.
12. Li XM, Zhang YZ, Xu YX, et al. Study on the relationship of MTHFR polymorphisms with unexplained recurrent spontaneous abortion. Chin J Med Genet, 2004, 21:39-42.
13. Kutteh WH, Park VM, Deitcher SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril, 1999, 71:1048-1053.
14. Sarig G, Younis JS, Hoffman R, et al. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril, 2002, 77:342-347.
15. Mandel H, Brenner B, Berant M, et al. Coexistence of hereditary homocysteinuria and factor V Leiden effect on thrombosis. N Engl J Med, 1996, 334:763-768.
16. van der Molen EF, Arends GE, Nelen WL, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy. Am J Obstet Gynecol, 2000, 182:1258-1263.