Off-label use of recombinant factor VIIA concentrates after cardiac surgery

Annals of Thoracic Surgery

Volumn 80, Issue 1, 2005, Pages 3-5

  Despotis, George ^a   Avidan, Michael ^a   Lublin, Douglas M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; APROTININ; CLOPIDOGREL; COAGULATING AGENT; HEPARIN; PLACEBO; PROTEIN C; PROTEIN S; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ANTICOAGULANT THERAPY; ANTICOAGULATION; BLEEDING; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CARDIOVASCULAR RISK; COMPARATIVE STUDY; COST BENEFIT ANALYSIS; DRUG APPROVAL; DRUG COST; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INDICATION; DRUG LABELING; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; EDITORIAL; FOOD AND DRUG ADMINISTRATION; HEART SURGERY; HEMOSTASIS; HUMAN; INCIDENCE; KIDNEY FAILURE; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROPHYLAXIS; STROKE; THROMBOEMBOLISM; THROMBOSIS; UNITED STATES;

CARDIAC SURGICAL PROCEDURES; FACTOR VII; HEMOSTATICS; HUMANS; POSTOPERATIVE HEMORRHAGE; RECOMBINANT PROTEINS; THROMBOEMBOLISM;

EID: 20544472175     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2005.04.007     Document Type: Editorial

References (18)

1. U. Hedner, E. Erhardtsen Potential role for rFVIIa in transfusion medicine Transfusion 42 2002 114 124
2. L.T. Goodnough, D.M. Lublin, L. Zhang, G. Despotis, C. Eby Transfusion medicine service policies for recombinant factor VIIa administration Transfusion 44 2004 1325 1331
3. S.A. Mayer, N.C. Brun, K. Begtrup Recombinant activated factor VII for acute intracerebral hemorrhage N Engl J Med 352 2005 777 785
4. M. Laffan, N.M. O'Connell, D.J. Perry, A.J. Hodgson, D. O'Shaughnessy, O.P. Smith Analysis and results of the recombinant factor VIIa extended-use registry Blood Coagul Fibrinolysis 14 Suppl 1 2003 S35 S38
5. J.D. Bui, G.D. Despotis, E.P. Trulock, G.A. Patterson, L.T. Goodnough Fatal thrombosis after administration of activated prothrombin complex concentrates in a patient supported by extracorporeal membrane oxygenation who had received activated recombinant factor VII J Thorac Cardiovasc Surg 124 2002 852 854
6. M. Aldouri The use of recombinant factor VIIa in controlling surgical bleeding in non-haemophiliac patients Pathophysiol Haemost Thromb 32 Suppl 1 2002 41 46
7. M.E. Halkos, J.H. Levy, E. Chen Early experience with activated recombinant factor VII for intractable hemorrhage following cardiovascular surgery Ann Thorac Surg 67 2005 1 11
8. K. Karkouti, W.S. Beattie, D.N. Wijeysundera Recombinant factor VIIa for intractable blood loss after cardiac surgery a propensity score-matched case-control analysis Transfusion 45 2005 26 34
9. P. Raivio, R. Suojaranta-Ylinen, A.H. Kuitunen Recombinant factor VIIa in the treatment of postoperative hemorrhage after cardiac surgery Ann Thorac Surg 80 2005 66 71
10. L.E. Nielsen, W.R. Bell, A.M. Borkon, C.A. Neill Extensive thrombus formation with heparin resistance during extracorporeal circulation. A new presentation of familial antithrombin III deficiency Arch Intern Med 147 1987 149 152
11. J.R. Hocker, K.L. Saving Fatal aortic thrombosis in a neonate during infusion of epsilon-aminocaproic acid J Pediatr Surg 30 1995 1490 1492
12. G.J. Despotis, V. Levine, A. Alsoufiev, J.H. Joist, L.T. Goodnough, M. Pasque Recurrent thrombosis of biventricular support devices associated with accelerated intravascular coagulation and increased heparin requirements J Thorac Cardiovasc Surg 112 1996 538 540
13. G.J. Despotis, V. Levine, H.J. Joist, S.A. Santoro, E. Mendeloff Multiple episodes of thrombosis with biventricular support devices with inadequate anticoagulation and evidence of accelerated intravascular coagulation J Thorac Cardiovasc Surg 112 1996 538 540
14. A.T. Cheung, S.K. Levin, S.J. Weiss, M.A. Acker, N. Stenach Intracardiac thrombus a risk of incomplete anticoagulation for cardiac operations Ann Thorac Surg 58 1994 541 542
15. S.M. Haddy, W.W. Shely, N. Rice Intravascular thrombosis after exsanguination in a patient treated with epsilon-aminocaproic acid J Cardiothorac Vasc Anesth 10 1996 510 512
16. M.P. Fanashawe, L. Shore-Lesserson, D.L. Reich Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest Anesthesiology 95 2001 1525 1527
17. S.W. Heindel, M.R. Mill, E.B. Freid, R.D. Valley, G.C. White, E.A. Norfleet Fatal thrombosis associated with a hemi-Fontan procedure, heparin-protamine reversal, and aprotinin Anesthesiology 94 2001 369 371
18. P.K. Smith Aprotinin Safe and effective only with the full-dose regimen Ann Thorac Surg 62 1996 1575 1577