Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil

Archives of Pharmacal Research

Volumn 20, Issue 6, 1997, Pages 550-554

  Yoon, Jung Hoon ^a   Lee, Chong Soon ^a  

^a Yeungnam University   (South Korea)

Author keywords

Anticancer drug; Chlorambucil; DNA interstrand cross links; Sequence specificity

Indexed keywords

EID: 20544466665     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975210     Document Type: Article

References (14)

1. Dong, Q., Barsky, D., Colvin, M. E., Melius, C. F., Ludeman, S. M., Moravek, J. F., Colvin, O. M., Bigner, D. D., Modrich, P., and Friedman, H. S. A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5′-d(GAC). Proc. Natl. Acad. Sci. USA, 92, 12170-12174 (1995).
2. Gale, E. F., Cundliffe, E., Reynolds, P. E., Richmond, M. H., and Waring, M. J. The Molecular Basis of Antibiotic Action; Wiley: New York (1981).
3. Hartley, J. A., Forrow, S. M., and Souhami, R. L. Effect of ionic strength and cationic DNA affinity binders on the DNA sequence selective alkylation of guanine N7-position by nitrogen mustards. Biochemistry, 29, 2985-2991 (1990).
4. Hausheer, F. H., Singh, U. C., Saxe, J. D., and Colvin, O. M. Identification of local determinants of DNA interstrand crosslink formation by cyclophosphamide metabolites. Anti-Cancer Drug Design, 4, 281-294 (1989).
5. Kohn, K. W., Hartley, J. A., and Mattes, W. B. Mechanism of DNA sequence selective alkylation of guanine-N7 position by nitrogen mustards. Nucleic Acids Res., 15, 10531-10549 (1987).
6. Kohn, K. W., Spear, C. L., and Doty, P. J. Interstrand crosslinking of DNA by nitrogen mustard. Mol. Biol., 19, 266-288 (1966).
7. Mattes, W. B., Hartley, J. A., and Kohn, K. W. DNA sequence selectivity of guanine N-7 alkylation by nitrogen mustards. Nucleic Acids Res., 14, 2971-2987 (1986).
8. Maxam, A., and Gilbert, W. Sequencing end-labeled DNA with base-specific chemical cleavage. Methods Enzymol., 65, 499-560 (1980).
9. Millard, J. T., Raucher, S. and Hopkins, P. B. Mechlorethamine cross-links deoxyguanosine residues at 5′-GNC sequences in duplex fragments. J. Am. Chem. Soc., 112, 2459-2460 (1990).
10. Ojwang, J. O., Grueneberg, D. A., and Loechler, E. L. Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link. Cancer Res., 49, 6529-6537 (1989).
11. Pieper, R., and Erickson, L. C. DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro. Carcinogenesis, 11, 1739-1746 (1990).
12. Remias, M. G., Lee, C.-S., Haworth, I. S. Molecular dynamics simulation of chlorambucil/DNA adducts. A structural basis for the 5′-GGC interstrand DNA crosslink formed by nitrogen mustards. J. Biomol. Struct. Dyn., 12, 911-934 (1995).
13. Rink, S. M., Solomon, M. S., Taylor, M. J., Rajur, S. B., McLaughlin, L. W., and Hopkins, P. B. Covalent structure of a nitrogen mustard-induced DNA interstrand cross-link: An N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5′-d(GNC). J. Am. Chem. Soc., 115, 2551-2557 (1993).
14. Wang, P., Bauer, G. B., Bennett, R. A. O., and Povirak, L. F. Thermolabile adenine adducts and AT base pair substitution induced by nitrogen mustard analogues in an SV40-based shuttle plasmid. Biochemistry, 30, 11515-11521 (1991).