Pathogenesis of foot ulcers and the need for offloading

Hormone and Metabolic Research

Volumn 37, Issue SUPPL. 1, 2005, Pages

  Rathur, H M ^a   Boulton, A J M ^a  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Amputation; Diabetic foot; Diabetic neuropathy; Foot ulcer; Total Contact Cast (TCC)

Indexed keywords

AMPUTATION; CONFERENCE PAPER; DIABETIC FOOT; ETHNIC DIFFERENCE; FOOT ULCER; HISTOPATHOLOGY; HUMAN; INCIDENCE; NEUROPATHY; PERIPHERAL NEUROPATHY; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; RISK FACTOR; SOCIOECONOMICS; STRESS; WEIGHT BEARING;

CASTS, SURGICAL; CHRONIC DISEASE; DIABETIC FOOT; FOOT; HUMANS;

EID: 20444496120     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-861398     Document Type: Conference Paper

References (80)

1. Wild S, Roglie G, Green A, King H, Global prevalence of diabetes: estimates for 2000 and projections for 2030. Diabetes Care; 2004; 27: 1047-1053
2. Boyko EJ, Ahroni JH, Smith DG, Davignon D. Increased mortality associated with diabetic foot ulcer. Diabetic Med 1996; 13: 967-972
3. Krentz AJ, Acheson P, Basu A, Kilvert A, Wright AD, Natrass M. Morbidity and mortality associated with diabetic foot disease: a 12-month prospective survey of hospital admissions in a single UK centre. Foot 1997; 7: 144-147
4. Jude EB, Boulton AJM. End stage complications of diabetic neuropathy. Diabetes Reviews 1999; 7: 395-410
5. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Rev 1999; 6: 245-252
6. Williams DRR, Airey M. The size of the problem: epidemiological and economical aspects of the diabetic foot. In: Boulton AJM, Connor H, Cavanagh PR (eds). The foot in diabetes; 3rd edition. Chichester: Wiley, 2000: 3-17
7. Reiber GE, Ledoux WR. Epidemiology of diabetic foot ulcers and amputations: evidence for prevention. In: Williams R, Herman W, Kinmonth AL, Wareham NJ (eds). The evidence base for diabetes care. Chichester: Wiley, 2002: 641-665
8. Carrington AL, Abbott CA, Griffiths J, Jackson N, van Ross ERE, Boulton AJM. A foot care programme for diabetic unilateral amputees. Diabetes Care 2001; 24: 216-221
9. Kumar S, Ashe H, Fernando DJS, Tsigos C, Young RJ, Boulton AJM. The prevalence of foot ulceration and its correlates in type 2 diabetic patients: a population-based study. Diabetic Med 1994; 11: 480-484
10. Abbott CA, Carrington AL, Ashe H et al. The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabetic Med 2002; 20: 377-384
11. Muller IS, de Graum WJ, van Gerwen WH et al. Foot ulceration and lower limb amputation in type 2 diabetic patients in Dutch primary health care. Diabetes Care 2002; 25: 570-574
12. Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJM. Diabetic Foot Syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-hispanic whites from a diabetes management cohort. Diabetes Care 2003; 26: 1435-1438
13. Humphrey ARG, Thomas K, Dowse GK, Zimmet PZ. Diabetes and nontraumatic lower extremity amputations. Incidence, risk factors and prevention: a 12 year follow-up study in Nauru. Diabetes Care 1996; 19: 710-714
14. Behhadj MA. La pace du pied diabetique [in French]. Diabete Metab 1998; 24 [Supp]: LXVII
15. Pendsey S. Epidemiological aspects of the diabetic foot. J Diabetes Develop Countries 1998; 2: 37-38
16. Young MA, Veves A, Breddy JL, Boulton AJM. The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds: a prospective study. Diabetes Care 1994; 17: 557-560
17. Abbott CA, Vileikyte L, Williamson S, Carrington AL, Boulton AJM. Multicentre study of the incidence of and predictive factors for diabetic neuropathic foot ulcers. Diabetes Care 1998; 21: 1071-1075
18. Larsson J, Apelqvist J, Agardh GD, Stenstrom A. Decreasing incidence of major amputation in diabetic patients: a consequence of a multidisciplinary foot care team approach? Diabetic Med 1995; 12: 770-776
19. Trautner C, Haastert B, Spraul M, Giani C, Berger M. Unchanged incidence of lower limb amputations in a German city 1990-1998. Diabetes Care 2001; 24: 855-859
20. Trautner C, Haastert B, Giani C, Berger M, Amputations and diabetes: a case control study. Diabetic Med 2002; 19: 35-40
21. No authors listed. An audit of amputations in a rural health district. Practical Diabetes Int 1997; 14: 174-178
22. Toledano H, Young MJ, Veves A, Boulton AJM. Why do Asian diabetic patients have fewer foot ulcers than Caucasians. Diabetic Med 1993; [Suppl 1]: 539
23. Chaturvedi N, Abbot CA, Whalley A, Leggetter SY, Boulton AJM. Risk of diabetes-related amputation in south Asians vs. Europeans in the UK. Diabetic Med 2002; 1019: 99-106
24. Leggetter SY, Chaturvedi N, Fuller JH, Edmonds ME. Ethnicity and risk of diabetes-related lower extremity amputation: a population-based, case-control study of Afro-Caribbeans and Europeans in the United Kingdom. Arch Int Med 2001; 162: 73-78
25. Resnick HE, Valsania P, Phillips CL. Diabetes mellitus and non-traumatic lower extremity in black and white Americans: the national health and nutrition examination survey epidemiology follow-up study 1971-1992. Arch Int Med 1999; 159: 2470-2475
26. Most RS, Sinnock P. The epidemiology of lower extremity amputations in diabetic individuals. Diabetes Care 1983; 6: 87-91
27. American Diabetes Association. Consensus development conference on diabetic wound care. Diabetes Care 1999; 22: 1354-1360
28. Shearer A, Schuffham P, Gordois A, Ogleshy A. Predicted costs and outcomes from reduced vibration detection in people with diabetes in the US. Diabetes Care 2003; 26: 2305-2310
29. Ragnarson-Tennvall G, Apelqvist J. Prevention of diabetes-related foot ulcers and amputations: a cost utility analysis based on Markov model simulation. Diabetologia 2001; 44: 2077-2087
30. Assal JP, Mehnert H, Tritschler HS, Sidorenko A, Keen H. On your feet' workshop on the diabetic foot. J Diabet Comp 2002; 16: 183-194
31. Ramsey SD, Newton K, Blough D et al. Incidence outcomes and costs of foot ulcers in patients with diabetes. Diabetes Care 1999; 22: 382-387
32. Diabetes care and research in Europe: the St Vincent Declaration. Diabet Med 1990; 7: 360
33. Larssen J. Lower extremity amputations in diabetic patients. Doctoral thesis. Lund University, 1994
34. Boulton AJM. The pathway to ulceration: aetiopathogenesis. In: Boulton AJM, Connor H, Cavanagh HPR (eds). The foot in diabetes, 3rd edition. Chichester: Wiley, 2000: 19-31
35. Reiber GE, Vileikyte L, Boyko EJ et al. Causal pathway for incident lower extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999; 22: 157-162
36. Boulton AJM, Hardisty CA, Betts RP et al. Dynamic foot pressure and other studies as diagnostic and management aids for diabetic neuropathy. Diabetes Care 1983; 6: 26-33
37. Katoulis EC, Ebdon-Parry M, Hollis S et al. Postural instability in diabetic patients at risk of foot ulceration. Diabetic Med 1997; 14: 296-300
38. Katoulis EC, Ebdon-Parry M, Lanshammer H et al. Gait abnormalities in diabetic neuropathy. Diabetes Care 1997; 20: 1904-1907
39. Vileikyte L, Rubin RR, Leventhal H. Psychological aspects of diabetic neuropathy and its late sequelae. Diab Metab Res Rev 2004; 20 [Suppl 1]: S13-S18
40. Young MJ, Boulton AJM, MacLeod AF, Williams DRR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the UK hospital clinic population. Diabetologia 1993; 36: 150-154
41. Mayfield JA, Sugarman JR. The use of the Semmes-Weinstein monofilament and other threshold tests for preventing foot ulcerations and amputations in persons with diabetes. J Fam Pract 2000; 49 [Suppl 11]:S17-S29
42. Booth J, Young MJ. Differences in the performance of commercially available monofilaments. Diabetes Care 2000; 23: 984-988
43. Miranda-Palma B, Basu S, Mizel MS et al. The monofilament as gold standard for foot ulcer risk screening: a reappraisal. Diabetes 2003; 53 [Suppl 1]: A63
44. Carrington AL, Shaw JE, Van Schie CHM, Abbott CA, Vileikyte L, Boulton AJM. Can motor nerve conduction velocity predict foot problems in diabetes over a six year outcome period? Diabetes Care 2002; 25: 2010-2015
45. National Diabetes Advisory Board. The prevention and treatment of five complications of diabetes: a guide for primary care practitioners. Atlanta, GA: Centers for Disease Control HHS publ. no. 83-8392, 1983
46. Jude EB, Oyibo SO, Chalmers N, Boulton AJM. Peripheral arterial disease in diabetic and non-diabetic patients: a comparison of severity and outcome. Diabetes Care 2001; 24: 1433-1437
47. Lavery LA, Armstrong DG, Vela SA et al. Practical criteria for screening patients at high risk of diabetic foot ulceration. Arch Int Med 1998; 26: 157-162
48. Murray HJ, Young MJ, Boulton AJM. The relationship between callus formation, high pressures and neuropathy in diabetic foot ulceration. Diabetic Med 1996; 13: 979-982
49. Valk GD, Kreigsman DM, Assendelf WJ. Patient education for reducing diabetic foot ulceration: a systematic review. Endocrinol Metab Clin N Amer 2002; 31: 633-658
50. McCabe CJ, Stevenson RC, Dolan AM. Evaluation of a diabetic foot screening and prevention programme. Diabetic Med 1998; 15: 80-84
51. Vileikyte L. Psychological and behavioural issues in diabetic neuropathic foot ulceration. In: Boulton AJM, Connor H, Cavanagh PR (eds). The foot in diabetes, 3rd edition. Chichester. Wiley, 2000: 121-130
52. Veves A, Boulton AJM. The optical pedobarograph. Clin Podiatr Med Surg 1993; 10: 463-470
53. Boulton AJM, Betts RP, Franks CI et al. Abnormalities of foot pressure in early diabetic neuropathy. Diabetic Med 1987; 4: 225-228
54. Boulton AJM, Betts RP, Franks CI, Ward JD, Duckworth T. The natural history of foot pressure abnormalities in neuropathic diabetic subjects. Diabetes Res 1987; 5: 73-77
55. Newrick PG, Cochrane T, Betts RP, Ward JD, Boulton AJM. Reduced hyperaemic response under the neuropathic diabetic foot. Diabetic Med 1988; 5: 570-573
56. Young MJ, Cavanagh PR, Thomas G et al. The effect of callus removal on dynamic plantar foot pressures in diabetic patients. Diabetic Med 1992; 9: 55-57
57. Veves A, Young MJ, Murray HJ, Boulton AJM. The risk of foot ulceration in diabetic patients with high foot pressures: a prospective study. Diabetologia 1993; 35: 660-663
58. Lavery LA, Armstrong DG, Wunderlich RP, R Tredwell J, Boulton AJM. Predictive value of foot pressure assessment when part of a population based diabetes disease management programme. Diabetes Care 2003; 26: 1069-1073
59. Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet 2003; 361: 1545-1551
60. Jude EB, Blakytny R, Bulmer J, Boulton AJM, Ferguson MWJ. Transforming growth factor-beta 1,2,3 and receptor type 1 and 2 in diabetic foot ulcers. Diabetic Med 2002; 19: 440-447
61. Lobmann R, Ambrosch A, Schultz G et al. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia 2002; 45: 1011-1016
62. Boulton AJM, Armstrong DG. Studies in planter diabetic neuropathic ulcers; time for a paradigm shift? Diabetes Care 2003; 26: 2689-2690
63. Brand PW. The Diabetic Foot. In: Ellenberg M, Rifkin H (eds). Diabetes mellitus: theory and practice, 3rd edn. New York: Med Exam Publishing, 1983: 829-849
64. Boulton AJM, Lawrence Lecture: the diabetic foot: neuropathic in aetiology? Diabetic Med 1990; 7: 852-858
65. Armstrong DG, Nguyen HC, Lavery LA, van Schie CH, Boulton AJM, Harkless LBI. Off-Loading the diabetic foot wound: a randomized clinical trial. Diabetes Care 2001; 24: 1019-1022
66. Armstrong DG, Stacpoole-Shea S. TCC and removable cast walker. Mitigation of plantar heel pressure. J Am Podiatr Med Assoc 1999; 89: 50-53
67. Boulton AJM, Bowker JH, Gadia M et al. Use of plaster casts in the management of diabetic neuropathic foot ulcers. Diabetes Care 1986; 9: 149-152
68. Mueller MJ, Diamond JE, Sinacore DR et al. Total contact casting in the treatment of diabetic plantar ulcers: controlled clinical trial. Diabetes Care 1989; 12: 384-388
69. Mason J, O'Keefe C, Hutchinson A, McIntosh A, Young R, Booth A. A systematic review of foot ulcers in patients with type 2 diabetes mellitus treatment. Diabetic Med 1999; 16: 889-909
70. Lavery LA, Vela SA, Lavery DC, Quebedeaux TL. Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations: a comparison of treatments. Diabetes Care 1996; 19: 818-821
71. Baumhauer JF, Wervery R, McWilliams J, Harris GF, Shereff MJ. A comparison study of plantar foot pressure in a standardized shoe, total contact cast prefabricated pneumatic walking brace. Foot Ankle Int 1997; 18: 26-33
72. Armstrong DG, Lavery LA, Kimbriel HR, Nixon BP, Boulton AJM. Activity patterns of patients with diabetic foot ulceration: patients with active ulceration may not adhere to pressure offloading regimen. Diabetes Care 2003; 26: 2595-2597
73. Veves A, Sheehan P, Pham HT. A randomized control trial of Promogran vs standard treatment in the management of diabetic foot ulcers. Arch Surg 2002; 137: 822-827
74. Ha Van G, Siney H, Hartmann-Heurtier A, Jacqueminet S, Greau F, Grimaldi A. Nonremovable, windowed, fibreglass cast boot in the treatment of diabetic planter ulcers: efficacy, safety and compliance. Diabetes Care 2003; 26: 2848-2852
75. Spencer S. Pressure relieving interventions for preventing and treating diabetic foot ulcers (Cochrane Review). In: The Cochrane Library. Issue 3. Chichester: John Wiley and Sons Ltd, 2002
76. Armstrong DG, Short B, Espensen EH, Abu-Ramman PL, Nixon BP, Boulton AJM. Technique for fabrication of an 'instant total contact cast' for treatment of neuropathic diabetic foot ulcers. J Am Pod Med Assoc 2002; 92: 405-408
77. Katz I, Harlan A, Miranda-Palma B et al. A randomised trial of two irremovable offloading devices in the management of plantar neuropathic diabetic foot ulcers. Diabetes Care 2005; 28: 555-559
78. Piaggesi A, Viacava P, Rizzo L et al. Semi-quantitative analysis of the histopathological features of the neuropathic foot ulcer-effects of pressure relief. Diabetes Care 2003; 26: 3123-3128
79. Knowles EA, Armstrong DG, Hayat SA, Boulton AJM et al. Offloading diabetic foot wounds using the scotchcast boot: a retrospective study. Ostomy Wound Manage 2002; 48: 50-53
80. Armstrong DG, Lavery LA, Wu S, Boulton AJ. Evaluation of removable and irremovable cast walkers in the healing of diabetic foot wounds: a randomized controlled trial. Diabetes Care 2005; 28: 551-554