Hemifusion in SNARE-mediated membrane fusion

Nature Structural and Molecular Biology

Volumn 12, Issue 5, 2005, Pages 417-422

  Xu, Yibin ^a   Zhang, Fan ^a   Su, Zengliu ^a   McNew, James A ^b   Shin, Yeon Kyun ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME; SNARE PROTEIN; LIPID; MEMBRANE PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SNC2 PROTEIN, S CEREVISIAE; SYNAPTOBREVIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CONTROLLED STUDY; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; ELECTRON SPIN RESONANCE; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SPIN LABELING;

ELECTRON SPIN RESONANCE SPECTROSCOPY; LIPIDS; MEMBRANE FUSION; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; R-SNARE PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SNARE PROTEINS; SPIN LABELS; VESICULAR TRANSPORT PROTEINS;

EID: 20444495341     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb921     Document Type: Article

References (36)

1. White, J.M. Membrane fusion. Science 258, 917-924 (1992).
2. Skehel, J.J. & Wiley, D.C. Coiled coils in both intracellular vesicle and viral membrane fusion. Cell 95, 871-874 (1998).
3. Chan, D.C. & Kim, P.S. HIV entry and its inhibition. Cell 93, 681-684 (1998).
4. Jahn, R., Lang, T. & Sudhof, T.C. Membrane fusion. Cell 112, 519-533 (2003).
5. Earp, L.J., Delos, S.E., Park, H.E. & White, J.M. The many mechanisms of viral membrane fusion proteins. Curr. Top. Microbiol. Immunol. 285, 25-66 (2005).
6. Chernomordik, L.V. & Kozlov, M.M. Protein-lipid interplay in fusion and fission of biological membranes. Annu. Rev. Biochem. 72, 175-207 (2003).
7. Kemble, G.W., Danieli, T. & White, J.M. Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell 76, 383-391 (1994).
8. Melikyan, G.B., Markosyan, R.M., Roth, M.G. & Cohen, F.S. A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion. Mol. Biol. Cell 11, 3765-3775 (2000).
9. Armstrong, R.T., Kushnir, A.S. & White, J.M. The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to support the hemifusion to fusion transition. J. Cell Biol. 151, 425-437 (2000).
10. Yang, L. & Huang, H.W. Observation of a membrane fusion intermediate structure. Science 297, 1877-1879 (2002).
11. Rothman, J.E. Mechanisms of intracellular protein transport. Nature 372, 55-63 (1994).
12. 2+ and drives membrane fusion. Cell 97, 165-174 (1999).
13. Weber, T. et al. SNAREpins: minimal machinery for membrane fusion. Cell 92, 759-772 (1998).
14. McNew, J.A. et al. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407, 153-159 (2000).
15. 2+-triggered exocytosis. Science 304, 289-292 (2004).
16. Grote, E., Baba, M., Ohsumi, Y. & Novick, P.J. Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J. Cell Biol. 151, 453-466 (2000).
17. Chernomordik, L.V. et al. Lysolipids reversibly inhibit Ca(2+)-, GTP-and pH-dependent fusion of biological membranes. FEBS Lett. 318, 71-76 (1993).
18. Peters, C. et al. Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion. Nature 409, 581-588 (2001).
19. McNew, J.A. et al. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J. Cell Biol. 150, 105-117 (2000).
20. Hubbell, W.L., Gross, A., Langen, R. & Lietzow, M.A. Recent advances in site-directed spin labeling of proteins. Curr. Opin. Struct. Biol. 8, 649-656 (1998).
21. Rabenstein, M.D. & Shin, Y.K. HIV-1 gp41 tertiary structure studied by EPR spectroscopy. Biochemistry 35, 13922-13928 (1996).
22. McHaourab, H.S., Lietzow, M.A., Hideg, K. & Hubbell, W.L. Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics. Biochemistry 35, 7692-7704 (1996).
23. Altenbach, C., Greenhalgh, D.A., Khorana, H.G. & Hubbell, W.L. A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin. Proc. Natl. Acad. Sci. USA 91, 1667-1671 (1994).
24. Macosko, J.C., Kim, C.H. & Shin, Y.K. The membrane topology of the fusion peptide region of influenza hemagglutinin determined by spin-labeling EPR. J. Mol. Biol. 267, 1139-1148 (1997).
25. Chen, Y., Xu, Y., Zhang, F. & Shin, Y.K. Constitutive versus regulated SNARE assembly: a structural basis. EMBO J. 23, 681-689 (2004).
26. Rossi, G., Salminen, A., Rice, L.M., Brunger, A.T. & Brennwald, P. Analysis of a yeast SNARE complex reveals remarkable similarity to the neuronal SNARE complex and a novel function for the C terminus of the SNAP-25 homolog, Sec9. J. Biol. Chem. 272, 16610-16617 (1997).
27. Meers, P., Ali, S., Erukulla, R. & Janoff, A.S. Novel inner monolayer fusion assays reveal differential monolayer mixing associated with cation-dependent membrane fusion. Biochim. Biophys. Acta 1467, 227-243 (2000).
28. Chernomordik, L.V., Frolov, V.A., Leikina, E., Bronk, P. & Zimmerberg, J. The pathway of membrane fusion catalyzed by influenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation. J. Cell Biol. 140, 1369-1382 (1998).
29. Mittal, A., Leikina, E., Chernomordik, L.V. & Bentz, J. Kinetically differentiating influenza hemagglutinin fusion and hemifusion machines. Biophys. J. 85, 1713-1724 (2003).
30. Poirier, M.A. et al. The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat. Struct. Biol. 5, 765-769 (1998).
31. Sutton, R.B., Fasshauer, D., Jahn, R. & Brunger, A.T. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature 395, 347-353 (1998).
32. Kweon, D.H., Kim, C.S. & Shin, Y.K. The membrane-dipped neuronal SNARE complex: a site-directed spin labeling electron paramagnetic resonance study. Biochemistry 41, 9264-9268 (2002).
33. Kweon, D.H., Kim, C.S. & Shin, Y.K. Insertion of the membrane-proximal region of the neuronal SNARE coiled coil into the membrane. J. Biol. Chem. 278, 12367-12373 (2003).
34. Tamm, L.K. Hypothesis: spring-loaded boomerang mechanism of influenza hemagglutinin-mediated membrane fusion. Biochim. Biophys. Acta 1614, 14-23 (2003).
35. Kweon, D.H., Kim, C.S. & Shin, Y.K. Regulation of neuronal SNARE assembly by the membrane. Nat. Struct. Biol. 10, 440-447 (2003).
36. Kweon, D.H. et al. Probing domain swapping for the neuronal SNARE complex with electron paramagnetic resonance. Biochemistry 41, 5449-5452 (2002).