Distinguishing between proliferating nodal lymphoid blasts in chronic myelogenous leukemia and non-Hodgkin lymphoma: Report of three cases and detection of a bcr/abl fusion signal by single-cell analysis

Pathology International

Volumn 55, Issue 5, 2005, Pages 273-279

  Yashima Abo, Akiko ^a   Satoh, Takashi ^a   Abo, Toru ^a   Aoki, Yusei ^a   Kowata, Shugo ^a   Ito, Shigeki ^a   Ishida, Yoji ^a   Fujiwara, Hitomi ^a   Maesawa, Chihaya ^a   Masuda, Tomoyuki ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Chronic myelogenous leukemia; Fluorescence in situ hybridization; Lymph node; Nodal blast proliferation; Non Hodgkin lymphoma

Indexed keywords

CD3 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; CD99 ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; MYELOPEROXIDASE; NAPHTHOL AS D CHLOROACETATE ESTERASE; NAPHTHOL AS D ESTERASE; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; BCR ABL GENE; BCR GENE; BLAST CELL; BONE MARROW CULTURE; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; CYTOPATHOLOGY; DIAGNOSTIC ACCURACY; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE EXPRESSION; GENE FUSION; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; LYMPH NODE; LYMPH NODE BIOPSY; LYMPHOBLASTOID CELL; NODAL BLAST PROLIFERATION; NONHODGKIN LYMPHOMA; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING;

ADULT; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD34; ANTIGENS, CD7; BLOTTING, SOUTHERN; CELL ADHESION MOLECULES; CELL PROLIFERATION; DNA NUCLEOTIDYLEXOTRANSFERASE; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC; LYMPH NODES; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; NAPHTHOL AS D ESTERASE; PEROXIDASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 20444486562     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2005.01824.x     Document Type: Article

References (17)

1. Kurarock R, Gutterman JU, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemia. N Engl J Med 1988; 319: 990-98.
2. Kantarjian HM, Deisseroth A, Kurzrock R, Estrov Z, Talpaz M. Chronic myelogenous leukemia: a concise update. Blood 1993; 82: 691-703.
3. Vardiman JW. Chronic myelogenous leukemia and the myeloproliferative disorders. In: Knowles DM, ed. Neoplastic Hematopathology. Baltimore: Williams & Wilkins, 1992; 1405-38.
4. Terjanian T, Kantarjian H, Keating M, Talpaz M, McCredie K, Freireich EJ. Clinical and prognostic features of patients with Philadelphia chromosome-positive chronic myelogenous leukemia and extramedullary disease. Cancer 1987; 59: 297-300.
5. Inverardi D, Lazzarino M, Morra E et al. Extramedullary disease in Ph-positive chronic myelogenous leukemia: frequency, clinical features and prognostic significance. Haematologica 1990; 75: 146-8.
6. Vardiman JW, Pierre R, Thiele J, Imbert M, Brunning BD, Flandrin G. Chronic myelogenous leukaemia. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2002; 20-26.
7. Ichinohasama R, Miura I, Takahashi N et al. Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis: report of two cases and review of the literature. Leukemia 2000; 14: 169-82.
8. Kantarjian HM, Keating MJ, Talpaz M et al. Chronic myelogenous leukemia in blast crisis. Analysis of 242 patients. Am J Med 1987; 83: 445-54.
9. Brunning RD, McKenna RW. Chronic myeloproliferative diseases. In: Juan R, ed. Tumors of the Bone Marrow. Atlas of Tumor Pathology, 3rd series, fascicle 9. Washington DC: Armed Forces Institute of Pathology, 1994; 195-254.
10. Delage R, Soiffer RJ, Dear K, Ritz J. Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia. Blood 1991; 78: 2759-67.
11. Takahashi N, Miura I, Saitoh K, Miura AB. Lineage involvement of stem cells bearing the Philadelphia chromosome in chronic myeloid leukemia in the chronic phase as shown by a combination of fluorescence-activated cell sorting and fluorescence in situ hybridization. Blood 1998; 92: 4758-63.
12. Traweek ST, Arber DA, Rappaport H, Brynes RK. Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol 1993; 17: 1011-19.
13. Menasce LP, Banerjee SS, Beckett E, Harris M. Extramedullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. Histopathology 1999; 34: 391-8.
14. Swerdlow SH, Berger F et al. Mantle cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2002; 168-70.
15. Ye CC, Echeverri C, Anderson JE et al. T-cell blast crisis of chronic myelogenous leukemia manifesting as a large mediastinal tumor. Hum Pathol 2002; 33: 770-73.
16. Zeppa P, Marino G, Picardi M, Luciano L, Vetrani A, Palombini L. Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology. Diagn Cytopathol 2002; 27: 158-60.
17. Kern WF, Spier CM, Hanneman EH, Miller TP, Matzner M, Grogan TM. Neural cell adhesion molecule-positive peripheral T-cell lymphoma: a rare variant with a propensity for unusual sites of involvement. Blood 1992; 79: 2432-7.