Pharmacokinetics of ranitidine and nizatidine in very elderly patients

American Journal of Therapeutics

Volumn 12, Issue 3, 2005, Pages 223-225

  Sasaki, Masato ^a   Sudoh, Toshiaki ^a   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Accumulation; Elderly; Nizatidine; Ranitidine

Indexed keywords

NIZATIDINE; RANITIDINE;

AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG SAFETY; FEMALE; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

AGED; AGED, 80 AND OVER; AREA UNDER CURVE; CROSS-OVER STUDIES; FEMALE; HALF-LIFE; HISTAMINE H2 ANTAGONISTS; HUMANS; NIZATIDINE; RANITIDINE;

EID: 20444481454     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Taeschner W, Vozeh S. Pharmacokinetic drug data. In: Speight TM, Holford NHG, eds. Avery's Drug Treatment, 4th ed. Adis, Auckland: Adis; 1997:1629-1664.
2. Zantac Tablets Product Information. In: Physkians' Desk Reference, 56th ed. Montvale: Medical Economics; 2002:1690-1692.
3. Axid Capsules Product Information. In: Physicians' Desk Reference, 56th ed. Montvale: Medical Economics; 2002:1903-1905.
4. Greene DS, Szego PL, Anslow JA, et al. The effect of age on ranitidine pharmacokinetics. Clin Pharmacol Ther. 1986;39:300-305.
5. Callaghan JT, Rubin A, Knadler MP, et al. Nizatidine, an H2-receptor antagonist: disposition and safety in the elderly. J Clin Pharmacol. 1987;27:618-624.
6. Epstein CM. Ranitidine and confusion [letter]. Lancet. 1984;1:1071.
7. Hughes JD, Reed WD, Serjeant CS. Mental confusion associated with ranitidine [letter]. Med J Aust. 1983;2:12-13.
8. Silverstone PH. Ranitidine and confusion [letter]. Lancet. 1984;1:1071.
9. Mihaly GW, Drummer OH, Marshall AW, et al. High pressure liquid chromatographic determination of ranitidine. J Pharm Sci. 1980;69:1155-1157.
10. Knadler MP, Bergstrom RF, Callaghan JT, et al. Nizatidine, an H2-blocker; its metabolism and disposition in man. Drug Metab Dispos. 1986;14:175-182.
11. Dixon JS, Borg-Costanzi JM, Langley SJ, et al. The effect of renal function on the pharmacokinetics of ranitidine. Eur J Clin Pharmacol. 1994;46:167-171.
12. Aronoff GR, Bergstrom RF, Bopp RJ, et al. Nizatidine disposition in subjects with normal and impaired renal function. Clin Pharmacol Ther. 1988;43:688-695.