Immunocytochemistry (p16INK4a) as an additional examination for cytological specimens class III D (munich classification II);Immunzytochemie (p16INK4a) als zusatzuntersuchung bei zytologischen befunden der gruppe III D

Zentralblatt fur Gynakologie

Volumn 127, Issue 3, 2005, Pages 140-145

  Ziemke, P ^a,b  

^a Gemeinschaftspraxis für Pathologie Dr D Klausnitzer und Dr P Ziemke   (Germany)

^b GP Pathologie   (Germany)

Author keywords

CIN; Gynecological cytology; HPV; III D; p16

Indexed keywords

PROTEIN P16INK4A;

ARTICLE; CYTODIAGNOSIS; DEVICE; DYSPLASIA; FEMALE; FOLLOW UP; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; NONHUMAN; PAPANICOLAOU TEST; PROGNOSIS; SQUAMOUS EPITHELIUM; VALIDATION PROCESS; WART VIRUS;

CARCINOMA IN SITU; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; PROGNOSIS; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 20444475755     PISSN: 00444197     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-836406     Document Type: Article

References (31)

1. Bayer-Pietsch E, Flenker H. Gynäkologische Zytologie mit der Pap-Spin-Technik. Frauenarzt 2004; 45: 1-6
2. 16INK4A Antigen in Thin-Layer, Liquid-Based Specimens. Acta Cytologica 2002; 46: 25-29
3. 16INK4A as an Adjunct Test in Liquid-Based Cytology. Acta Cytologica 2003; 25: 8-11
4. Böcking A. Abklärung plattenepithelialer Dysplasien mittels DNA-Bildzytometrie. Dt Ärztebl 1998; 95: A658-A662
5. Böcking A, Motherby H. Abklärung zervikaler Dysplasien mittels DNA-Bild-Zytometrie. Pathologe 1999; 20: 25-33
6. Böhmer G, Petty KU, Iftner T, Brummer O, Günter HH, Flemming P, Kühnle H. Der DNS-Nachweis humaner Papillomviren mittels Hybrid Capture ist als sekundäre Screeningmethode bei rezidivierenden atypischen Abstrichen der Befundklasse Pap III D ungeeignet. Zentralbl Gynakol 2002; 124: 111-115
7. Breinl H. Zytologie des Zervixkarzinoms und seiner Vorstadien. 15. Fortbildungstagung für klinische Zytologie. München; 26.-30. November 1999
8. Elit LM. Pitfalls in the Diagnosis of Cervical Intraepithelial Neoplasia 1. Journal of Lower Genital Tract Disease 2004; 8: 181-187
9. Grubert TA, Friese K. Impfung gegen HPV. Gynäkologe 2003; 36: 313-322
10. Gullota G, Margariti PA, Rabitti C, Balsamo G, Valle D, Capelli A, Mancuso S. Cytology, histology, and colposcopy in the diagnosis of neoplastic non-invasive epithelial lesions of the cervix. Eur J Gynecol Onc 1997; 18: 36-38
11. Hording U, Junge J, Rygaard C, Lundvall F. Management of low-grade CIN: follow up or treatment? Eur J Obstet Gynecol Reprod Biol 1995; 62: 49-52
12. Ikenberg H. HPV-Nachweis zur Triage bei auffälligen zytologischen Befunden. Gynäkologe 2003; 36: 297-304
13. INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001; 92: 276-284
14. v Knebel Doeberitz M. Aspekte der Molekularen Pathogenese des Zervixkarzinoms für neue Marker in der Krebsfrüherkennung und Diagnostik. Zentrabi Gynakol 2001; 123: 186-191
15. v Knebel Doeberitz M. New markers for cervical dysplasia to visualisw the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer 2002; 38: 2229-2242
16. Moseley RP, Paget S. Liquid-based cytology: is his the way forward for cervical screening? Cytopathology 2002; 13: 71-82
17. INK4A as a marker for cervical dyskariosis: CIN and cCGIN in cervical biopsies and ThinPrep™ smears. J Clin Pathol 2003; 56: 56-63
18. Östör AG. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 1993; 12: 186-192
19. Ridder R, Wentzensen N, v Knebel Doeberitz M. Biomarker in der Differenzialdiagnostik von HPV-assoziierten Läsionen. Gynäkologe 2003; 36: 323-330
20. Sadler L, Saftlas A, Wang W, Exeter M, Whittaker J, McCowan L. Treatment for Cervical Intraepithelial Neoplasia and Risk of Preterm Delivery. Obstet Gynecol Surv. 2004; 59: 698-699
21. INK4a as an adjunct marker in liquid-based cervical cytology. Int J Cancer 2004; 108: 871-876
22. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Expression Status of p16 Protein is Associated with Human Papillomavirus Oncogenic Potential in Cervical and Genital Lesions. Am J Pathol 1998; 153: 1741-1748
23. INK4A in Liquid-Based Specimens (SurePath) as a Marker of Cervical Dysplasia and Neoplasia. Diagn Cytopathol 2002; 27: 365-370
24. Schneider A, Zahm DM, Kirchmayr R, Schneider VL Screening for cervical intraepithelial neoplasie grade 2/3: validity of catologic study, cervicography, and human papillomavirus detection. Am J Obstet Gynecol 1996; 174: 1534-1541
25. Soost HJ, Baur S. Gynäkologische Zytodiagnostik. 5. Aufl. Thieme, Stuttgart, New York 1990
26. INK4a Staining Atlas. DakoCytomation 2004
27. INK4a-Positive Cells in Cervical Cytology Samples. Acta Cytologica 2004;48:771-782
28. Volgareva G, Zavalishina L, Andreeva Y, Frank G, Krutikova E, Golovina D, Bliev A, Spitkovsky D, Ermilova V, Kisseljov F. Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells. BMC Cancer 2004; 4: 58
29. Weintraub J, Morabia A. Efficacy of a Liquid-Based Thin Layer Method for Cervical Cancer Screening in a Population with a Low Incidence of Cervical Cancer. Diagn Cytopathol 2000; 22: 52-59
30. Weynand B, Berlière M, Haumont E, Massart F, Pourvoyeur A, Bernard P, Donnez J, Galant C. A New, Liquid-Based Cytology Technique. Acta Cytologica 2003; 47: 149-153
31. zur Hausen H. Papillomavirus and cancer: from basic studies to clinical application. Nature Rev Mol Cell Biol 2002; 2: 342-350