Red cell aspartate aminotransferase saturation with oral pyridoxine intake

Sao Paulo Medical Journal

Volumn 123, Issue 2, 2005, Pages 54-57

  Oshiro, Marilena ^a   Nonoyama, Kimiyo ^a   Gomes Oliveira, Raimundo Antônio ^a,b   de Oliveira Barretto, Orlando Cesar ^a,c  

^a INSTITUTO ADOLFO LUTZ   (Brazil)

^b FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aspartate aminotransferase; Myelofibrosis; Pyridoxal phosphate; Pyridoxine; Sideroblastic anemia

Indexed keywords

ASPARTATE AMINOTRANSFERASE; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE;

ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CIRCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; DRUG SAFETY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MYELOFIBROSIS; NORMAL HUMAN; PEYRONIE DISEASE; SIDEROBLASTIC ANEMIA; VITAMIN SUPPLEMENTATION;

EID: 20444474168     PISSN: 15163180     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-31802005000200004     Document Type: Article

References (21)

1. Anderson BB, Fulford-Jones CE, Child JA, Beard ME, Bateman CJ. Conversion of vitamin B6 compounds to active forms in the red blood cell. J Clin Invest. 1971;50(9):1901-9.
2. Delport R, Ubbink JB, Vermaak WJ, Shaw A, Bissbort S, Becker PJ. Relationship between maternal and neonatal vitamin B6 metabolism: perspectives from enzyme studies. Nutrition. 1991;7(4):260-4; discussion 264-6.
3. Hathcock JN. Vitamins and minerals: efficacy, and safety. Am J Clin Nutr. 1997;66(2):427-37.
4. Olszewer E. Vitaminas. In: Olszewer E (ed.). ABC da Medicina Ortomolecular. São Paulo: Tecnopress; 1997. p. 12-3.
5. Rojer RA, Mulder NH, Nieweg HO. Response to pyridoxine hydrochloride in refractory anemia due to myelofibrosis. Am J Med. 1978;65(4):655-60.
6. Bitsch R. Vitamin B6. Int J Vitam Nutr Res. 1993;63(4):278-82.
7. Leklem JE. Vitamin B6. In: Shilds ME, Olson JA, Shike M, editors. Modern nutrition in health in disease. Philadelphia: Lea & Febiger; 1994. p. 383-94.
8. Sauberlich HE, Canham JE, Baker EM, Raica N, Herman YF. Biochemical assessment of the nutritional status of vitamin B6 in the human. Am J Clin Nutr. 1972;25(6):629-42.
9. Vudhivai N, Pongpaew P, Prayurahong B, et al. Vitamin B1, B2, and B6 in relation to anthropometry, hemoglobin and albumin of newborns and their mothers from northeast Thailand. Int J Vitam Nutr Res. 1990;60(1):75-80.
10. Solomon LR, Hillman RS. Vitamin B6 metabolism in human red cells. I. Variations in normal subjects. Enzyme. 1978;23(4):262-73.
11. Beutler E. Red cell metabolism - A manual of biochemical methods. 3rd ed. Orlando: Grune & Stratton; 1984.
12. Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 2002;75(4):616-58.
13. Bender DA. Novel functions of vitamin B6. Proc Nutr Soc. 1994;53(3):625-30.
14. Rucker RB, Stites T. New perspective on function of vitamins. Nutrition. 1994;10(6):507-13.
15. Garret RH, Grisham CM. Coenzymes and vitamins. In: Voet D. Voet JG, editors. Biochemistry. Florida: Saunders College Publishing; 1995. p. 474-80.
16. Award Jr. WM. Iron and heme metabolism. In: Devlin TM, editor. Textbook of Biochemistry with clinical correlations. New York: Wiley-Liss; 1997. p.1001-24.
17. Bull BS, Breton-Gorius J. Morphology of the erythron. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, editors. Williams Hematology. 5th ed. New York: McGraw-Hill; 1995. p.354-63.
18. Rose DP, Strong R, Folkard J, Adams PW. Erythrocyte aminotransferase activities in women using oral contraceptives and the effect of vitamin B6 supplementation. Am J Clin Nutr. 1973;26(1):48-52.
19. Fonda ML. Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. J Biol Chem. 1992;267(22):15978-83.
20. Fischer I, Walter H. Aspartate aminotransferase (GOT) from young and old human erythrocytes. J Lab Clin Med. 1971;78(5):736-45.
21. Solomon LR. Considerations in the use of B6 vitamers in hematologic disorders: I. Red cell transport and metabolism of pyridoxal. Blood. 1982;59(3):495-501.