Crotalidae polyvalent immune Fab (Ovine) antivenom is effective in the neutralization of South American viperidae venoms in a murine model

Annals of Emergency Medicine

Volumn 45, Issue 6, 2005, Pages 595-602

  Richardson III, William H ^a,e   Tanen, David A ^b   Tong, Tri C ^c   Betten, David P ^c   Carstairs, Shaun D ^b   Williams, Saralyn R ^c   Cantrell, Frank L ^d   Clark, Richard F ^c  

^a Palmetto Richland Memorial Hospital   (United States)

^b NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^c UCSD MEDICAL CENTER   (United States)

^d California Poison Control System   (United States)

^e UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROTALIDAE POLYVALENT IMMUNE FAB ANTISERUM; SNAKE VENOM; SNAKE VENOM ANTISERUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROSS REACTION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENVENOMATION; LD 50; LETHALITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; TREATMENT OUTCOME;

ANIMALS; ANTIVENINS; CROSS REACTIONS; CROTALID VENOMS; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN FRAGMENTS; LETHAL DOSE 50; MALE; MICE; RANDOM ALLOCATION; SNAKE BITES; SURVIVAL RATE; VIPERIDAE;

EID: 20444472000     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2004.08.038     Document Type: Article

References (23)

1. H.M. Parrish Incidence of treated snakebites in the United States Public Health Rep 81 1966 269 276
2. S.R. Offerman, S.P. Bush, and J.A. Moynihan Crotaline Fab antivenom for the treatment of children with rattlesnake envenomation Pediatrics 110 2002 968 971
3. S.A. Minton Non-native venomous snakes in the United States Wild Environ Med 7 1996 297 303
4. T.L. Litovitz, W. Klein-Schwartz, and S. White 2000 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 19 2001 337 395
5. T.L. Litovitz, W. Klein-Schwartz, and G.C. Rodgers Jr. 2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 20 2002 391 452
6. W.A. Watson, T.L. Litovitz, and G.C. Rodgers Jr. 2002 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 21 2003 352 421
7. P. Consroe, N.B. Egan, and F.E. Russell Comparison of a new ovine antigen binding fragment (Fab) antivenin for United States Crotalidae with the commercial antivenin for protection against venom-induced lethality in mice Am J Trop Med Hyg 53 1995 507 510
8. R.C. Dart, S.A. Seifert, and L. Carroll Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning Ann Emerg Med 30 1997 33 39
9. R.C. Dart, S.A. Seifert, and L.V. Boyer A randomized multicenter trial of Crotalinae polyvalent immune Fab (ovine) antivenom for the treatment of Crotalidae snakebite in the United States Arch Intern Med 161 2001 2030 2036
10. S.P. Bush, S.M. Green, and J.A. Moynihan Crotalidae Polyvalent Immune Fab (ovine) antivenom is efficacious for envenomations by southern Pacific rattlesnakes (Crotalus helleri) Ann Emerg Med 40 2002 619 624
11. E.J. Lavonas, C.J. Gerardo, and G. O'Malley Initial experience with Crotalidae Polyvalent Immune Fab (ovine) antivenom in the treatment of copperhead snakebite Ann Emerg Med 43 2004 200 206
12. M.S. Wisniewski, R.E. Hill, and J.M. Havey Australian tiger snake (Notechis scutatus) and Mexican coral snake (Micrurus species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model J Toxicol Clin Toxicol 41 2003 7 10
13. J. Meier, and R.D. Theakston Approximate LD50 determinations of snake venoms using eight to ten experimental animals Toxicon 24 1986 395 401
14. Protherics, Inc CroFab Crotalidae polyvalent immune Fab (ovine) [package insert] 2000 Protherics, Inc. Nashville, TN
15. G.G. Zbinden, and M. Flury-Roversi Significance of the LD50-test for the toxicological evaluation of chemical substances Arch Toxicol 47 1981 77 99
16. S.G. Anderson, J.M. Gutierrez, and C.L. Ownby Comparison of the immunogenicity and antigenic composition of ten Central American snake venoms Toxicon 31 1993 1051 1059
17. J.M. Gutierrez, M.C. Dos Santos, and M.F. Furtado Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes Toxicon 29 1991 1273 1277
18. R.F. Clark, S.R. Williams, and S.P. Nordt Successful treatment of crotalid-induced neurotoxicity with a new polyspecific crotalid Fab antivenom Ann Emerg Med 30 1997 54 57
19. G. Bogarin, J.F. Morais, and I.K. Yamaguchi Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica Toxicon 38 2000 1429 1441
20. C.L. Ownby, and T.R. Colberg Comparison of the immunogenicity and antigenicity composition of several venoms of snakes in the family Crotalidae Toxicon 28 1990 189 199
21. E.E. Sanchez, M.S. Ramirez, and J.A. Galan Cross reactivity of three antivenoms against North American snake venoms Toxicon 41 2003 315 320
22. V. Arce, E. Rojas, and C.L. Ownby Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes Toxicon 41 2003 851 860
23. J.G. Schier, S.W. Weiner, and M. Touger Efficacy of Crotalidae Polyvalent Antivenin for treatment of hognosed viper (Porthidium nasutum) envenomation Ann Emerg Med 41 2003 391 395