메뉴 건너뛰기




Volumn 29, Issue 4, 2005, Pages 262-268

Investigation of a fatality due to trazodone poisoning: Case report and literature review

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; DIPYRONE; DRUG METABOLITE; MEPIVACAINE; NITROGEN; NORAMIDOPYRINE; PHOSPHORUS; PRAZEPAM; TRAZODONE;

EID: 20444471110     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/29.4.262     Document Type: Review
Times cited : (22)

References (52)
  • 3
    • 0019980358 scopus 로고
    • Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone
    • S. Caccia, M.H. Fong, S. Garattini, and M.G. Zanini. Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone. J. Pharm. Pharmacol. 34: 605-606 (1982).
    • (1982) J. Pharm. Pharmacol. , vol.34 , pp. 605-606
    • Caccia, S.1    Fong, M.H.2    Garattini, S.3    Zanini, M.G.4
  • 5
    • 20244388096 scopus 로고    scopus 로고
    • Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients
    • K. Mihara, N. Yasui-Furukori, T. Kondo, M. Ishida, S. Ono, T. Ohkubo, T. Osanai, K. Sugawara, K. Otani, and S. Kaneko. Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients. Ther. Drug. Monit. 24: 563-566 (2002).
    • (2002) Ther. Drug. Monit. , vol.24 , pp. 563-566
    • Mihara, K.1    Yasui-Furukori, N.2    Kondo, T.3    Ishida, M.4    Ono, S.5    Ohkubo, T.6    Osanai, T.7    Sugawara, K.8    Otani, K.9    Kaneko, S.10
  • 7
    • 85039409083 scopus 로고
    • Thomson Micromedex, Micromedex® Healthcare Series, exp 6/2004
    • Drugdex® Product Index and Martindale Product Index. 1974-2004 Thomson Micromedex, Micromedex® Healthcare Series Vol. 120, exp 6/2004.
    • (1974) Drugdex® Product Index and Martindale Product Index , vol.120
  • 8
    • 0020619803 scopus 로고
    • Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly
    • A.J. Bayer, M.S. Pathy, and S.I. Ankier. Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly. Br. J. Clin. Pharmacol. 16: 371-376 (1983).
    • (1983) Br. J. Clin. Pharmacol. , vol.16 , pp. 371-376
    • Bayer, A.J.1    Pathy, M.S.2    Ankier, S.I.3
  • 9
    • 0019859218 scopus 로고
    • (-)-m-chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone
    • S. Caccia, M. Ballabio, R. Samanin, M.G. Zanini, and S. Garattini. (-)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. J. Pharm. Pharmacol. 33: 477-478 (1981).
    • (1981) J. Pharm. Pharmacol. , vol.33 , pp. 477-478
    • Caccia, S.1    Ballabio, M.2    Samanin, R.3    Zanini, M.G.4    Garattini, S.5
  • 13
    • 0023473309 scopus 로고
    • Plasma trazodone concentrations in elderly depressed inpatients: Cardiac effects and short-term efficacy
    • J.E. Spar. Plasma trazodone concentrations in elderly depressed inpatients: cardiac effects and short-term efficacy. J. Clin. Psychopharmacol. 7: 406-409 (1987).
    • (1987) J. Clin. Psychopharmacol. , vol.7 , pp. 406-409
    • Spar, J.E.1
  • 15
    • 0026544791 scopus 로고
    • Hyponatraemia and seizure due to overdose of trazodone
    • G. Balestrieri, B. Cerudelli, S. Ciaccio, and D. Rizzoni. Hyponatraemia and seizure due to overdose of trazodone. B. M. J. 304 (6828): 686 (1992).
    • (1992) B. M. J. , vol.304 , Issue.6828 , pp. 686
    • Balestrieri, G.1    Cerudelli, B.2    Ciaccio, S.3    Rizzoni, D.4
  • 16
    • 0028807474 scopus 로고
    • Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose
    • S.M. Salerno, J.S. Strong, B.J. Roth, and V. Sakata. Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose. Am. J. Respir. Crit. Care Med. 152: 2170-2172 (1995).
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 2170-2172
    • Salerno, S.M.1    Strong, J.S.2    Roth, B.J.3    Sakata, V.4
  • 17
    • 0031034705 scopus 로고    scopus 로고
    • Serotonin syndrome associated with trazodone
    • R. Rao. Serotonin syndrome associated with trazodone. Int. J. Geriatr. Psychiatry 12: 129-130 (1997).
    • (1997) Int. J. Geriatr. Psychiatry , vol.12 , pp. 129-130
    • Rao, R.1
  • 18
    • 0031614761 scopus 로고    scopus 로고
    • Serotonergic syndrome with trazodone
    • R. Rao. Serotonergic syndrome with trazodone. Hosp. Med. 59: 79 (1998).
    • (1998) Hosp. Med. , vol.59 , pp. 79
    • Rao, R.1
  • 19
    • 0032787983 scopus 로고    scopus 로고
    • Seizure and hyponatraemia after overdose of trazadone
    • D. Vanpee, P. Laloyaux, and J.B. Gillet. Seizure and hyponatraemia after overdose of trazadone. Am. J. Emerg. Med. 17: 430-431 (1999).
    • (1999) Am. J. Emerg. Med. , vol.17 , pp. 430-431
    • Vanpee, D.1    Laloyaux, P.2    Gillet, J.B.3
  • 20
    • 0035180381 scopus 로고    scopus 로고
    • Venlafaxine- and trazodone-induced serotonin syndrome
    • R.E. McCue and M. Joseph. Venlafaxine- and trazodone-induced serotonin syndrome. Am. J. Psychiatry 158: 2088-2089 (2001).
    • (2001) Am. J. Psychiatry , vol.158 , pp. 2088-2089
    • McCue, R.E.1    Joseph, M.2
  • 21
    • 0034766408 scopus 로고    scopus 로고
    • An unusual presentation of sertraline and trazodone overdose
    • D.E. Adson, S. Erickson-Birkedahl, and M. Kotlyar. An unusual presentation of sertraline and trazodone overdose. Ann. Pharmacother. 35: 1375-1377 (2001).
    • (2001) Ann. Pharmacother. , vol.35 , pp. 1375-1377
    • Adson, D.E.1    Erickson-Birkedahl, S.2    Kotlyar, M.3
  • 22
    • 0019134753 scopus 로고
    • Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone)
    • M. Volz and H.M. Kellner. Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). Br. J. Clin. Pharmacol. 10: 299S-308S (1980).
    • (1980) Br. J. Clin. Pharmacol. , vol.10
    • Volz, M.1    Kellner, H.M.2
  • 23
    • 0021947961 scopus 로고
    • Toxicity and elimination of trazodone after overdose
    • E. Hassan and D.D. Miller. Toxicity and elimination of trazodone after overdose. Clin. Pharm. 4: 97-100 (1985).
    • (1985) Clin. Pharm. , vol.4 , pp. 97-100
    • Hassan, E.1    Miller, D.D.2
  • 24
    • 0023010749 scopus 로고
    • Trazodone overdose: Four years of experience from voluntary reports
    • D.E. Gamble and L.G. Peterson. Trazodone overdose: four years of experience from voluntary reports., J. Clin. Psychiatry 47: 544-546 (1986).
    • (1986) J. Clin. Psychiatry , vol.47 , pp. 544-546
    • Gamble, D.E.1    Peterson, L.G.2
  • 25
    • 0026494803 scopus 로고
    • Post-mortem toxico-kinetics of trazodone
    • A. Martin and D.J. Pounder. Post-mortem toxico-kinetics of trazodone. Forensic Sci. Int. 56: 201-207 (1992).
    • (1992) Forensic Sci. Int. , vol.56 , pp. 201-207
    • Martin, A.1    Pounder, D.J.2
  • 26
    • 0028348246 scopus 로고
    • A fatal case of trazodone and dothiepin poisoning: Toxicological findings
    • W. Lambert, J. Van Bocxlaer, M. Piette, and A. De Leenheer. A fatal case of trazodone and dothiepin poisoning: toxicological findings. J. Anal. Toxicol. 18: 176-179 (1994).
    • (1994) J. Anal. Toxicol. , vol.18 , pp. 176-179
    • Lambert, W.1    Van Bocxlaer, J.2    Piette, M.3    De Leenheer, A.4
  • 27
    • 0033918691 scopus 로고    scopus 로고
    • Postmortem forensic toxicology of trazodone
    • K.E. Goeringer, L. Raymon, and B.K. Logan. Postmortem forensic toxicology of trazodone. J. Forensic Sci. 45: 850-856 (2000).
    • (2000) J. Forensic Sci. , vol.45 , pp. 850-856
    • Goeringer, K.E.1    Raymon, L.2    Logan, B.K.3
  • 28
    • 0035990649 scopus 로고    scopus 로고
    • Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: Comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection
    • M.A. Martínez, C. Sánchez de la Torre, and E. Almarza. Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection. J. Anal. Toxicol. 26: 296-302 (2002).
    • (2002) J. Anal. Toxicol. , vol.26 , pp. 296-302
    • Martínez, M.A.1    Sánchez De La Torre, C.2    Almarza, E.3
  • 29
    • 0041932359 scopus 로고    scopus 로고
    • A comparative solid-phase extraction study for the simultaneous determination of fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection
    • M.A. Martinez, C. Sánchez de la Torre, and E. Almarza. A comparative solid-phase extraction study for the simultaneous determination of fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection. J. Anal. Toxicol. 27: 353-358 (2003).
    • (2003) J. Anal. Toxicol. , vol.27 , pp. 353-358
    • Martinez, M.A.1    Sánchez De La Torre, C.2    Almarza, E.3
  • 30
    • 1842529407 scopus 로고    scopus 로고
    • A comparative solid-phase extraction study for the simultaneous determination of fluvoxamine, mianserin, doxepine, citalopram, paroxetine, and etoperidone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection
    • M.A. Martinez, C. Sánchez de la Torre, and E. Almarza. A comparative solid-phase extraction study for the simultaneous determination of fluvoxamine, mianserin, doxepine, citalopram, paroxetine, and etoperidone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection. J. Anal. Toxicol. 28: 174-180 (2004).
    • (2004) J. Anal. Toxicol. , vol.28 , pp. 174-180
    • Martinez, M.A.1    Sánchez De La Torre, C.2    Almarza, E.3
  • 31
    • 0022931445 scopus 로고
    • Determination of trazodone and its metabolite, m-CPP, in serum and urine by HPLC
    • A.S. di Tella, C. di Nunzio, P. Ricci, and G. Parisi. Determination of trazodone and its metabolite, m-CPP, in serum and urine by HPLC. J. Anal. Toxicol. 10: 233-235 (1986).
    • (1986) J. Anal. Toxicol. , vol.10 , pp. 233-235
    • Di Tella, A.S.1    Di Nunzio, C.2    Ricci, P.3    Parisi, G.4
  • 32
    • 0022588017 scopus 로고
    • Analysis of trazodone and m-chlorophenylpiperazine in plasma and brain tissue by high-performance liquid chromatography
    • R.L. Miller and C.L. De Vane. Analysis of trazodone and m-chlorophenylpiperazine in plasma and brain tissue by high-performance liquid chromatography. J Chromatogr. 374: 388-393 (1986).
    • (1986) J. Chromatogr. , vol.374 , pp. 388-393
    • Miller, R.L.1    De Vane, C.L.2
  • 33
    • 0028954184 scopus 로고
    • High-performance liquid Chromatographic determination of trazodone and 1-m-chlorophenylpiperazine with ultraviolet and electrochemical detector
    • T. Ohkubo, T. Osanai, K. Sugawara, M. Ishida, K. Otani, K. Mihara, and N. Yasui. High-performance liquid Chromatographic determination of trazodone and 1-m-chlorophenylpiperazine with ultraviolet and electrochemical detector. J. Pharm. Pharmacol. 47: 340-344 (1995).
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 340-344
    • Ohkubo, T.1    Osanai, T.2    Sugawara, K.3    Ishida, M.4    Otani, K.5    Mihara, K.6    Yasui, N.7
  • 34
    • 0030940630 scopus 로고    scopus 로고
    • Determination of trazodone and its metabolite, 1-m- chlorophenylpiperazine, in human plasma and red blood cell samples by HPLC
    • G.T. Vatassery, L.A. Holden, D.K. Hazel, and M.W. Dysken. Determination of trazodone and its metabolite, 1-m-chlorophenylpiperazine, in human plasma and red blood cell samples by HPLC. Clin. Biochem. 30: 149-153 (1997).
    • (1997) Clin. Biochem. , vol.30 , pp. 149-153
    • Vatassery, G.T.1    Holden, L.A.2    Hazel, D.K.3    Dysken, M.W.4
  • 36
    • 84973815489 scopus 로고
    • Trazodone overdosage: Experience from a poison information service
    • J.A. Henry and C.J. Ali. Trazodone overdosage: experience from a poison information service. Hum. Toxicol. 2: 353-356 (1983).
    • (1983) Hum. Toxicol. , vol.2 , pp. 353-356
    • Henry, J.A.1    Ali, C.J.2
  • 37
    • 0342360044 scopus 로고
    • Death involving trazodone
    • D. Demorest. Death involving trazodone. J. Anal. Toxicol. 7: 63 (1983).
    • (1983) J. Anal. Toxicol. , vol.7 , pp. 63
    • Demorest, D.1
  • 39
    • 0021352289 scopus 로고
    • Trazodone overdose: Report of two cases
    • I. Root and G.B. Ohlson. Trazodone overdose: report of two cases. J. Anal. Toxicol. 8: 91-94 (1984).
    • (1984) J. Anal. Toxicol. , vol.8 , pp. 91-94
    • Root, I.1    Ohlson, G.B.2
  • 40
    • 0021321963 scopus 로고
    • Acute trazodone poisoning: Clinical signs and plasma concentrations
    • J.A. Henry, C.J. Ali, R. Caldwell, and R.J. Flanagan. Acute trazodone poisoning: clinical signs and plasma concentrations. Psychopathology 17: 77-81 (1984).
    • (1984) Psychopathology , vol.17 , pp. 77-81
    • Henry, J.A.1    Ali, C.J.2    Caldwell, R.3    Flanagan, R.J.4
  • 42
    • 0034843452 scopus 로고    scopus 로고
    • Fatal overdose with trazodone: Case report and literature review
    • de Meester, G. Carbutti, L. Gabriel, and J.M. Jacques. Fatal overdose with trazodone: case report and literature review. Acta Clin. Belg. 56: 258-261 (2001).
    • (2001) Acta Clin. Belg. , vol.56 , pp. 258-261
    • De Meester1    Carbutti, G.2    Gabriel, L.3    Jacques, J.M.4
  • 45
    • 0021211702 scopus 로고
    • Complete heart block following a single dose of trazodone
    • J.L. Rausch, D.M. Pavlinac, and P.E. Newman. Complete heart block following a single dose of trazodone. Am. J. Psychiatry 141: 1472-1473 (1984).
    • (1984) Am. J. Psychiatry , vol.141 , pp. 1472-1473
    • Rausch, J.L.1    Pavlinac, D.M.2    Newman, P.E.3
  • 47
    • 0022527294 scopus 로고
    • A case of trazodone-induced ventricular tachycardia
    • M.D. Aronson and H. Hafez. A case of trazodone-induced ventricular tachycardia. J. Clin. Psychiatry 47: 388-389 (1986).
    • (1986) J. Clin. Psychiatry , vol.47 , pp. 388-389
    • Aronson, M.D.1    Hafez, H.2
  • 48
    • 0023447117 scopus 로고
    • Postural hypotension with syncope possibly precipitated by trazodone
    • B. Spivak, M. Radvan, and M. Shine. Postural hypotension with syncope possibly precipitated by trazodone. Am. J. Psychiatry 144: 1512-1513 (1987).
    • (1987) Am. J. Psychiatry , vol.144 , pp. 1512-1513
    • Spivak, B.1    Radvan, M.2    Shine, M.3
  • 49
    • 0025341360 scopus 로고
    • Trazodone-related exercise-induced nonsustained ventricular tachycardia
    • R.N. Vitullo, J.M. Wharton, N.B. Allen, and E.L. Pritchett. Trazodone-related exercise-induced nonsustained ventricular tachycardia. Chest 98: 247-248. (1990).
    • (1990) Chest , vol.98 , pp. 247-248
    • Vitullo, R.N.1    Wharton, J.M.2    Allen, N.B.3    Pritchett, E.L.4
  • 50
    • 0028810537 scopus 로고
    • QT prolongation and polymorphous ventricular tachycardia associated with trazodone-amiodarone combination
    • A. Mazur, B. Strasberg, J. Kusniec, and S. Sclarovsky. QT prolongation and polymorphous ventricular tachycardia associated with trazodone-amiodarone combination. Int. J. Cardiol. 52: 27-29 (1995).
    • (1995) Int. J. Cardiol. , vol.52 , pp. 27-29
    • Mazur, A.1    Strasberg, B.2    Kusniec, J.3    Sclarovsky, S.4
  • 51
    • 0033007726 scopus 로고    scopus 로고
    • Prolonged QT interval after trazodone overdose
    • J.L. Levenson. Prolonged QT interval after trazodone overdose. Am. J. Psychiatry 156: 969-970 (1999).
    • (1999) Am. J. Psychiatry , vol.156 , pp. 969-970
    • Levenson, J.L.1
  • 52
    • 0031795570 scopus 로고    scopus 로고
    • Trazodone is metabolized to m-chlorophenylpiperazine by CYP 3A4 from human sources
    • S. Rotzinger, J. Fang, and G.B. Baker. Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Drug Metab. Dispos. 26: 572-575 (1998).
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 572-575
    • Rotzinger, S.1    Fang, J.2    Baker, G.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.