Selectivity control by use of near-IR for a hydrogenation process

Organic Process Research and Development

Volumn 9, Issue 3, 2005, Pages 344-347

  De Smet, Koen ^a   Van Dun, Jan ^a   Stokbroekx, Bard ^a   Spittaels, Tom ^a   Schroyen, Christine ^a   Van Broeck, Peter ^a   Lambrechts, Julien ^a   Van Cleuvenbergen, Dirk ^a   Smout, Guy ^a   Dubois, Jeroen ^a   Horvath, Andras ^a   Verbraeken, Jurgen ^a   Cuypers, Jef ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CHLOROETHYL) 6,7,8,9 TETRAHYDRO 9 HYDROXY 2 METHYL 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; 3 (2 CHLOROETHYL) 9 HYDROXY 2 METHYL 4H PYRIDO[1,2 A]PYRIMIDIN 4 ONE; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; BIOREACTOR; CORRELATION ANALYSIS; HYDROGENATION; MOLECULAR MODEL; NEAR INFRARED SPECTROSCOPY;

EID: 20444470143     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op049782x     Document Type: Article

References (8)

1. Janssen, C. G. M.; Knaeps, A. G.; Kennis, L. E. J.; Vandenberk, J. EP 0368388, 1990.
2. Rein, A. R.; Donahue, S. M.; Pavlosky, M. A. Curr. Opin. Drug Discovery Dev. 2000, 3, 734.
3. Blanco, M.; Coello, J, Iturriaga, H, Maspoch, S., de la Pezuela, C. Analyst 1998, 123, 135-150.
4. Colthup, N. B.; Daly, L. H.; Wiberley, S. E. Introduction to infrared and Roman spectroscopy; Academic Press: New York, 1990.
5. Reactions were performed on lab scale where we took five samples which were analyzed four times by NIR to include small temperature differences in the NIR model.
6. This rough NIR-lab model was not optimized in detail on lab scale. We found it useful to further optimize the NIR model in the production equipment.
7. Each sample was analyzed by NIR (lab model) and HPLC. Differences between the NIR and HPLC results are due to different reaction conditions and the nonoptimized NIR-model.
8. http://www.fda.gov/cder/OPS/PAT.htm#Additional.