Determination of MDMA and MDA in rat urine by semi-micro column HPLC-fluorescence detection with DBD-F and their monitoring after MDMA administration to rat

Luminescence

Volumn 20, Issue 3, 2005, Pages 210-215

  Wada, Mitsuhiro ^a   Nakamura, Shinichi ^a   Tomita, Mamoru ^a,b   Nakashima, Mihoko N ^a   Nakashima, Kenichiro ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b Forensic Science Laboratory   (Japan)

Author keywords

3,4 methylenedioxyamphetamine (MDA); 3,4 methylenedioxymethamphetamine (MDMA); 4 (N,N dimethylaminosulphonyl) 7 fluoro 1,2,3 benzoxadiazole (DBD F); HPLC; Rat urine

Indexed keywords

BODY FLUIDS; DRUG PRODUCTS; FLUORESCENCE; HEXANE;

3,4-METHYLENEDIOXYAMPHETAMINE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; 4-(N,N-DIMETHYLAMINOSULPHONYL)-7-FLUORO-1,2,3-BENZOXADIAZOLE (DBD-F); BORATE BUFFER; BUFFER PH; HPLC; INTERNAL STANDARDS; METHYLENEDIOXYMETHAMPHETAMINE; MICRO-COLUMNS; RAT URINE;

RATS;

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; BORIC ACID; BUFFER; CARBON 11; HEXANE; HYDROGEN; IMIDAZOLE; NITROGEN; OXYGEN; PHENYLALANINE;

ANIMAL EXPERIMENT; CALIBRATION; CONFERENCE PAPER; COOLING; EVAPORATION; EXCITATION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONITORING; NONHUMAN; RAT; TEMPERATURE; URINALYSIS;

EID: 20444462755     PISSN: 15227235     EISSN: 10991271     Source Type: Journal    
DOI: 10.1002/bio.821     Document Type: Conference Paper

References (20)

1. Stout PR, Horn CK, Klette KL. Rapid simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by solid-phase extraction and GC-MS: a method optimized for high-volume laboratories. J. Anal. Toxicol. 2002; 26: 253-261.
2. Gentili S, Torresi A, Marsili R, Chiarotti M, Macchia T. Simultaneous detection of amphetamine-like drugs with headspace solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B 2002; 780: 183-192.
3. Huang Z, Zhang S. Confirmation of amphetamine, methamphetamine, MDA and MDMA in urine samples using disk solid-phase extraction and gas chromatography-mass spectrometry after immunoassay screening. J. Chromatogr. B. 2003; 792: 241-247.
4. Ugland HG, Krogh M, Rasmussen KE. Automated determination of 'Ecstasy' and amphetamines in urine by SPME and capillary gas chromatography after propylchloroformate derivatization. J. Pharm. Biomed. Anal. 1999; 19: 463-475.
5. Matsushima K, Nagai T, Kamiyama S. Optical isomer analysis of 3,4-methylenedioxyamphetamine analogues and their stereoselective disposition in rats. J. Anal. Toxicol. 1998; 22: 33-39.
6. Soares ME, Carvalho M, Carmo H et al. Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis. Biomed. Chromatogr. 2004; 18: 125-131.
7. Talwar D, Watson ID, Stewart MJ. Routine analysis of amphetamine class drugs as their naphthaquinone derivatives in human urine by high-performance liquid chromatography. J. Chromatogr. B. 1999; 735: 229-241.
8. Herraez-Hernandes R, Campins-Falco P, Verdu-Andres J. Sensitive determination of methylenedioxylated amphetamines by liquid chromatography. Analyst 2001; 126: 581-586.
9. Yamada H, Yamahara A, Yasuda S et al. Dansyl chloride derivatization of methamphetamine: a method with advantages for screening and analysis of methamphetamine in urine. J. Anal. Toxicol. 2002; 26: 17-22.
10. Geiser L, Cherkaoui S, Veuthey JL. Simultaneous analysis of some amphetamine derivatives in urine by non-aqueous capillary electrophoresis coupled to electrospray ionization mass spectrometry. J. Chromatogr. A 2000; 895: 111-121.
11. Nakashima K, Suetsugu K, Yoshida K et al. High-performance liquid chromatography with chemiluminescence detection of methamphetamine and its related compounds using 4-(N,N-dimethylaminosulfonyl)-7-fluoro-1,2,3- benzoxadiazole. Biomed. Chromatogr. 1992; 6: 149-154.
12. Uzu S, Imai K, Nakashima K, Akiyama S. 4-(N,N-dimethylaminosulfonyl)-7- fluoro-1,2,3-benzoxadiazole as chemilumigenic reagent for high performance liquid chromatographic peroxyoxalate chemiluminescence detection. Biomed. Chromatogr. 1991; 5: 184-185.
13. Uzu S, Nakashima K, Akiyama S. Use of 4-(N,N-dimethylaminosulfonyl)-7- fluoro-1,2,3-benzoxadiazole as a labeling reagent for peroxyoxalate chemiluminescence detection and its application to the determination of the beta-blocker metoprolol in serum by high-performance liquid chromatography. Analyst 1991; 116: 1353-1357.
14. Nagai N. Kanyaku maou seibun kenkyu seiseki (zoku). Yakugaku Zasshi 1893; 13: 901-933.
15. Al-Dirbashi O, Kuroda N, Akiyama S, Nakashima K. High-performance liquid chromatography of methamphetamine and its related compounds in human urine following derivatization with fluorescein isothiocyanate. J. Chromatogr. B 1997; 695: 251-258.
16. Al-Dirbashi O, Kuroda N, Nakashima K. Characterization of the fluorescence properties of 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole derivatives of some primary and secondary sympathomimetic amines. Anal. Chim. Acta 1998; 365: 169-176.
17. Al-Dirbashi O, Kuroda N, Inuduka S, Menichini F, Nakashima K. HPLC with fluorescence detection of methamphetamine and amphetamine in segmentally analyzed human hair. Analyst 1999; 124: 493-497.
18. Kaddoumi A, Kubota A, Nakashima NM, Takahashi M, Nakashima K. High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1H-imidazole-2-yl) benzoyl chloride as a label. Biomed. Chromatogr. 2001; 15: 379-388.
19. Fitzgerald RL, Blanke RV, Rosecrans JA, Glennon RA. Stereochemistry of the metabolism of MDMA to MDA. Life Sci. 1989; 45: 295-301.
20. Cho AK, Hiramatsu M, Distenfamo EW, Chang AS, Jenden DJ. Stereochemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: a pharmacokinetic analysis. Drug Metab. Dispos. 1990; 18: 686-691.