Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs

Indian Journal of Experimental Biology

Volumn 43, Issue 6, 2005, Pages 498-502

  Sharma, Sameer ^a   Jain, N K ^a   Kulkarni, S K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Aspartame; NSAIDs; Opioids; Synergism

Indexed keywords

ACETIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ASPARTAME; CARRAGEENAN; MORPHINE; NAPROXEN; NARCOTIC AGENT; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PENTAZOCINE; SULFONAMIDE; SWEETENING AGENT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG INTERACTION; EDEMA; INFLAMMATION; MOUSE; PAIN; PAIN ASSESSMENT; RAT; TIME; WISTAR RAT;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTAME; CARRAGEENAN; DRUG INTERACTIONS; EDEMA; INFLAMMATION; MICE; MORPHINE; NAPROXEN; NARCOTICS; PAIN; PAIN MEASUREMENT; PENTAZOCINE; RATS; RATS, WISTAR; SULFONAMIDES; SWEETENING AGENTS; TIME FACTORS;

EID: 20444439635     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Nikfar S, Abdollahi M, Sarkarati F & Etemad F, Interaction between calcium channel blockers and sweetening agents on morphine- induced analgesia in mice by formalin test, Gen Pharmacol, 3 (1998) 431.
2. Bergmann F, Lieblich L, Cohen E & Ganchrow J R, Influences of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats, Behav Neural Biol, 44 (1985) 347.
3. Kanarek R B, White E S, Biegen M T & Marks-Kaufman R, Dietary influences on morphine-induced analgesia in rats, Pharmac Biochem Behav, 38 (1991) 681.
4. Koster R, Anderson M & DeBeer E J, Acetic acid for analgesic screening, Fed Proc, 18 (1959) 4.
5. Kulkarni S K, Mehta A K & Kunchandy J, Anti-inflammatory actions of clonidine, guanfacine and B-HT920 against various inflammagen-induced acute paw edema in rats, Arch Int Pharmacodyn Ther, 279 (1986) 324.
6. Aley K O, Green P G & Levine J D, Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal, J Neurosci, 15 (1995) 8031.
7. Labuda C J & Fuchs P N, A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis, Life Sci, 69 (2001) 443.
8. Nikfar S, Abdollahi M, Etemad F & Sharifzadeh M, Effects of sweetening agents on morphine induced analgesia in mice by formalin test, Gen Pharmacol, 29 (1997) 583.
9. Edmundson A B & Manion C V, Treatment of osteoarthritis with aspartame, Clin Pharmacol Ther, 63 (1998) 580.
10. Abdollahi M, Sarrafzadeh J, Nikfar S & Roshanzamir F, Mechanism of aspartame-induced antinociception in mice, Indian J Pharmacol, 35 (2003) 37.