Glycoproteins contained within Soamsan, a traditional oriental medicine, are the main class of active ingredients responsible for the medicine-induced immune stimulation

Journal of Biochemistry and Molecular Biology

Volumn 38, Issue 2, 2005, Pages 253-257

  Lee, Jeong Chae ^a   Lee, Kyung Yeol ^b   Jung, Ha Na ^b   Kim, Jae Gon ^c   Jang, Yong Suk ^b  

^a Chonbuk National University   (South Korea)

^b Institute for Molecular Biology and Genetics   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Glycoproteins; Immune stimulation; Traditional medicine

Indexed keywords

CYTOKINE; GLYCOPROTEIN; IMMUNOLOGICAL ADJUVANT; PLANT EXTRACT; SOAMSAN; VEGETABLE PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ISOLATION AND PURIFICATION; LYMPHOCYTE ACTIVATION; MOUSE; ORIENTAL MEDICINE; SPLEEN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; CYTOKINES; GLYCOPROTEINS; LYMPHOCYTE ACTIVATION; MEDICINE, ORIENTAL TRADITIONAL; MICE; PLANT EXTRACTS; PLANT PROTEINS; SPLEEN;

EID: 20444439235     PISSN: 12258687     EISSN: 12258687     Source Type: Journal    
DOI: 10.5483/bmbrep.2005.38.2.253     Document Type: Article

References (12)

1. Chung, S. H., Terashi, H., Rhodes, L. M., Moon, N., Dunham, W. R. and Marcelo, C. L. (2001) The effect of three Korean traditional medicines on the growth rate of cultured human keratinocytes. J. Ethnopharmacol. 74, 53-61.
2. Fang, J. N., Proksch, A. and Wagner, H. (1985) Immunologically active polysaccharides of Acanthopanax senticosus. Phytochemistry 24, 2619-2622.
3. Ha, J. Y. and Lee, H. (1998) Antitumor and immune modulatory effects of Gagamleejungtang in BALB/c mice. Kor. J. Oriental. Pathology 12, 73-81.
4. Kim, E. H., Lee, J. C., Kim, J., Son, Y. O., Jung, G. H. and Jang, Y. S. (2002a) Modulation of antigen-specific immune responses by the oral administration of a traditional medicine, Bo-yang-hwan-o-tang. Immunopharmacol. Immunotoxicol. 24, 423-440.
5. Kim, E. H., Lee, J. C., Park, C. H., Lee, M. Y. and Jang, Y. S. (2002b) Soamsan, a traditional Korean medicine, enhances antigen-specific immune responses in low-responder mice via the combined activity of glycoproteins and endotoxins. Int. Immunopharmacol. 2, 1529-1540.
6. Kim, S. H. and Lim, J. S. (1999) Effects of Korean traditional medicine on murine hematopoiesis (I): Regulation of hematopoietic cytokine expression. Kor. J. Immunol. 21, 165-174.
7. Lee, J. C., Kim, J. and Jang, Y. S. (2003) Ethanol-eluted extract of Rhus verniciflua Stokes inhibits cell growth and induces apoptosis in human lymphoma cells. J. Biochem. Mol. Biol. 36, 337-343.
8. Lee, J. C. and Lim, K. T. (2001) Inhibitory effects of the ethanol extract of Ulmus davidiana on apoptosis induced by glucose-glucose oxidase and cytokine production in cultured mouse primary immune cells. J. Biochem. Mol. Biol. 34, 463-471.
9. Oka, S., Shigeta, S., Ono, K. and Jyo, T. (1987) An epitope residing in carbohydrate chains of sea squirt antigen termed Girep. J. Allergy Clin. Immunol. 80, 57-63.
10. Paik, S. Y., Ra, K. S., Chang, I. S., Park, Y. C., Park, H. S., Baik, H. S., Yun, J. W. and Choi, J. W. (2003) Purification and characterization of complement-activating acidic polysaccharides from the fruits of Capsicum annuum. J. Biochem. Mol. Biol. 36, 230-236.
11. Shan, B. E., Yoshida, Y., Sugiura, T. and Yamashita, U. (1999) Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. Int. J. Immunopharm. 21, 149-159.
12. Yoshida, Y., Wang, M. Q., Liu, J. N., Shan, B. N. and Yamashita, U. (1997) Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int. J. Immunopharmacol. 19, 359-370.