Functional heartburn: Misdiagnosed gastroesophageal reflux or a distinct entity?

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 2, Issue 3, 2005, Pages 120-121

  Fass, Ronnie ^a   Dickman, Ram ^a  

^a SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON PUMP INHIBITOR;

ACIDITY; CLINICAL FEATURE; DIAGNOSTIC ERROR; DISEASE CLASSIFICATION; ESOPHAGITIS; ESOPHAGUS FUNCTION; GASTROESOPHAGEAL REFLUX; HEARTBURN; HIATUS HERNIA; HUMAN; HYPERALGESIA; LOWER ESOPHAGUS SPHINCTER; PH MEASUREMENT; PHENOTYPE; PRIORITY JOURNAL; RETROSTERNAL PAIN; REVIEW;

DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS;

EID: 20444435953     PISSN: 17434378     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncpgasthep0113     Document Type: Review

References (10)

1. Fass R et al. (2001) Nonerosive reflux disease-current concepts and dilemmas. Am J Gastroenterol 96: 303-314
2. Fass R et al. (1998) Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 115: 1363-1373
3. Lind T et al. (1997) Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 32: 974-979
4. Richter JE et al. (2000) Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch Intern Med 160: 1803-1809
5. Fass R et al. (2000) Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy - a prospective, randomized, multi-centre study. Aliment Pharmacol Ther 14: 1595-1603
6. Frazzoni M et al. (2004) Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 20: 81-88
7. Martinez SD et al. (2003) Non-erosive reflux disease (NERD)-acid reflux and symptom patterns. Aliment Pharmacol Ther 17: 537-545
8. Watson RG et al. (1997) Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux - the "sensitive oesophagus". Gut 40: 587-590
9. Fass R and Tougas G (2002) Functional heartburn: the stimulus, the pain, and the brain. Gut 51: 885-892
10. Hobson AR et al. (2004) The role of esophageal afferent pathway sensitivity in non-erosive reflux disease [abstract #128]. Gastroenterology 126 (Suppl 2): A-18