Shengmai San, a Chinese herbal medicine protects against rat heat stroke by reducing inflammatory cytokines and nitric oxide formation

Journal of Pharmacological Sciences

Volumn 98, Issue 1, 2005, Pages 1-7

  Wang, Nien Lu ^a,b   Chang, Cheng Kuei ^b,c   Liou, Yann Lin ^d   Lin, Chia Li ^d   Lin, Mao Tsun ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Aminoguanidine; Cerebral ischemia; Heat stroke; Nitric oxide; Shengmai San; Striatum

Indexed keywords

AMINOGUANIDINE; CYTOKINE; GINSENG EXTRACT; GINSENOSIDE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OPHIOPOGON JAPONICUS EXTRACT; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; SHENGMAI SAN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CHINESE MEDICINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; GINSENG; HEAT STRESS; HEAT STROKE; HERBAL MEDICINE; HYPOTENSION; IMMUNOREACTIVITY; MALE; MEAN ARTERIAL PRESSURE; MEDICINAL PLANT; NONHUMAN; OPHIOPOGON JAPONICUS; RAT; RAT STRAIN; SCHISANDRA CHINENSIS; SCHISANDRACEAE;

EID: 20444426558     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FP0050018     Document Type: Article

References (33)

1. Hall DM, Baumgardner KR, Oberley TD, Gisolfi CV. Splanchnic tissues undergo hypoxic stress during whole body hyperthermia. Am J Physiol. 1999;276:G1195-G1203.
2. Hall DM, Buettner GR, Oberley LW, Xu L, Matthes RD, Gisolfi CV. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. Am J Physiol. 2001; 280:H509-H521.
3. Chang CP, Lee CC, Chen SH, Lin MT. Aminoguanidine protects against intracranial hypertension and cerebral ischemic injury in experimental heatstroke. J Pharmacol Sci. 2004;95:56-64.
4. Shapiro Y, Alkan M, Epstein Y, Newman F, Magazanik A. Increase in rat intestinal permeability to endotoxin during hyperthermia. Eur J Appl Physiol Occup Physiol. 1986;55:410-412.
5. Liu CC, Chen ZC, Cheng BC, Lin MT. Prior antagonism of endothelin-lA receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke. J Pharmacol Sci. 2004;96: 177-187.
6. Bouchama A, Knochem JP. Heat stroke. N Engl J Med. 2002;346:1978-1988.
7. Lin MT. Pathogenesis of an experimental heatstroke model. Clin Exp Pharmacol Physiol. 1999;26:826-827.
8. Fang J, Jiang J, Luo DC. Effect of Shengmai San oral fluid on coronary arteriosclerotic. Chin Med J. 1987;26:403.
9. Zhao M, Brong H, Lu B, Ihu X, Huang C, Yang J. Effect of Shengmai San on serum lipid peroxidation in acute viral myocarditis. J Combined Traditional Chin Western Med. 1996;16:142-145.
10. Wang X, Magara T, Konishi T. Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, Shengmai san, in rats. Free Radic Res. 1999;31:449-455.
11. Wang NL, Liou YL, Lin MT, Lin CL, Chang CK. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci. 2005;97:253-265.
12. Kao TY, Chio CC, Lin MT. Hypothalamic dopamine release and local cerebral blood flow during onset of heatstroke in rats. Stroke. 1994;25:2483-2487.
13. Kao TY, Lin MT. Brain serotonin depletion attenuates heatstroke-induced cerebral ischemia and cell death in rats. J Appl Physiol. 1996;80:680-684.
14. Lin MT, Liu HH, Yang YL. Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke. Am J Physiol. 1997;273:H2072-H2077.
15. Hammami MM, Bouchama A, Al Sedairy S, Shail E, AlOhaly Y, Mohamed GE. Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heat stress. Crit Care Med. 1997;25:1314-1319.
16. Bouchama A, al Sedairy S, Siddiqui S, Shail E, Rezeig M. Elevated pyrogenic cytokines in heatstroke. Chest. 1993;104: 1498-1502.
17. Yang CY, Lin MT. Oxidative stress in rats with heatstroke-induced cerebral ischemia. Stroke. 2002;33:790-794.
18. Liu CC, Chien CH, Lin MT. Glucocorticoids reduce interleukin-1 concentration and result in neuroprotective effects in rat heatstroke. J Physiol (Lond). 2000;527:333-343.
19. Togashi H, Mori K, Ueno K, Matsumoto M, Suda N, Saito H, et al. Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis. Neurosci Lett. 1998;240:53-57.
20. Novack TA, Dillon MC, Jackson WT. Neurochemical mechanisms in brain injury and treatment: a review. J Clin Exp Neuropsychol. 1996;18:685-706.
21. Niu KC, Lin KC, Yang CY, Lin MT. Protective effects of alphatocopherol and mannitol in both circulatory shock and cerebral ischemia injury in rat heatstroke. Clin Exp Pharmacol Physiol. 2003;30:745-751.
22. Nathan C, Xie Q-W. Nitric oxide synthesis: roles, tolls, and controls. Cell. 1994;78:915-918.
23. Chou YT, Lin MT, Lee CC, Wang JJ. Hypothermia attenuates cerebral dopamine overloading and gliosis in rats with heat-stroke. Neurosci Lett. 2003;336:5-8.
24. G-monomethyl-L-arginine or indomethacin. J Pharmacol Exp Ther. 1995;272:452-459.
25. Galea E, Feinstein DL, Reis DJ. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc Natl Acad Sci USA. 1992;89:10945-10949.
26. Lin HC, Wan FJ, Kang BH, Wu CC, Tseng CJ. Systemic administration of lipopolysaccharide induces release of nitric oxide and glutamate and c-fos expression in the nucleus tractus solitarii of rats. Hypertension. 1999;33:1218-1224.
27. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemie brain. J Cereb Blood Flow Metab. 2001;21:2-14.
28. Wang JL, Ke DS, Lin MT. Heat shock pretreatment may protect against heatstroke-induced circulatory shock and cerebral ischemia by reducing oxidative stress and energy depletion. Shock. 2005;23:161-167.
29. Chang CP, Hsu YC, Lin MT. Magnolol protects against cerebral ischemic injury of rat heatstroke. Clin Exp Pharmacol Physiol. 2003;30:387-392.
30. Lin MT, Kao TY, Jin YT, Chen CF. Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Res Bull. 1995;37:595-598.
31. Murray PT, Wylam ME, Umans JG. Nitric oxide and septic vascular dysfunction. Anesth Analg. 2000;90:89-101.
32. Szabo C, Mitchell JA, Thiemermann C, Vane JR. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol. 1993;108:786-792.
33. Titheradge MA. Nitric oxide in septic shock. Biochim Biophys Acta. 1999;1411:437-455.