FGF 23 and phosphatemia;FGF 23 et phosphatémie

Immuno-Analyse et Biologie Specialisee

Volumn 20, Issue 3, 2005, Pages 136-143

  Salles, J P ^a,c   Moulin, P ^a   Briand Mesange F ^c   Conte Auriol, F ^a,c   Gennero, I ^b,c   Tauber, M ^a,c   Fauvel, J ^b,c  

^a HÔPITAL DES ENFANTS   (France)

^b Serv Univ Psychiat l'Enfant l'A   (France)

^c INSERM   (France)

Author keywords

FGF 23; PHEX; Phosphate; Renal insufficiency; Rickets

Indexed keywords

CALCITRIOL; CALCIUM; FIBROBLAST GROWTH FACTOR 23; FRIZZLED PROTEIN; GLYCOPROTEIN; HYPOCALCIN; KERATINOCYTE GROWTH FACTOR; OXYGENASE; PHOSPHATE; PHOSPHOPROTEIN; PROTEIN PHEX; PROTEINASE; SIALOPROTEIN; UNCLASSIFIED DRUG;

BIOSYNTHESIS; BONE DYSPLASIA; BONE GROWTH; BONE METABOLISM; BONE MINERALIZATION; CALCIUM METABOLISM; HOMEOSTASIS; HUMAN; HYPERPHOSPHATEMIA; HYPOPHOSPHATEMIA; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; KIDNEY FAILURE; KIDNEY TUBULE ABSORPTION; OSTEOBLAST; OSTEOMALACIA; PATHOPHYSIOLOGY; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PHOSPHATE TRANSPORT; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; VITAMIN D RESISTANT RICKETS;

EID: 20444424491     PISSN: 09232532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immbio.2005.04.001     Document Type: Article

References (37)

1. D. Prie, V. Huart, N. Bakouh, G. Planelles, O. Dellis, and B. Gerard Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter N. Engl. J. Med. 347 2002 983 991
2. L.D. Quarles FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization Am. J. Physiol. Endocrinol. Metab. 285 2003 E1 E9
3. C.R. Dunstan, H. Zhou, and M.J. Seibel Fibroblast growth factor 23: a phosphatonin regulating phosphate homeostasis Endocrinol. 145 2004 3084 3086
4. L.D. Quarles, and M.K. Drezner Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem J. Clin. Endocrinol. Metab. 86 2001 494 496
5. M.J. Econs, and P.T. McEnery Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder J. Clin. Endocrinol. Metab. 82 1997 674 681
6. M.J. Econs, P.T. McEnery, F. Lennon, and M.C. Speer Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13 J. Clin. Invest. 100 1997 2653 2657
7. The ADHR Consortium Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 Nat. Genet. 26 2000 345 348
8. K.E. White, G. Carn, B. Lorenz-Depiereux, A. Benet-Pages, T.M. Strom, and M.J. Econs Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23 Kidney Int. 60 2001 2079 2086
9. A.E. Nelson, R.C. Bligh, M. Mirams, A. Gill, A. Au, and A. Clarkson Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia J. Clin. Endocrinol. Metab. 88 2003 4088 4094
10. M. Riminucci, M.T. Collins, N.S. Fedarko, N. Cherman, A. Corsi, and K.E. White FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting J. Clin. Invest. 112 2003 683 692
11. The HYP. Consortium A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium Nat. Genet. 11 1995 130 136
12. M.L. Lipman, D. Panda, H.P. Bennett, J.E. Henderson, E. Shane, and Y. Shen Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity J. Biol. Chem. 273 1998 13729 13737
13. I.A. Holm, A.E. Nelson, B.G. Robinson, R.S. Mason, D.J. Marsh, and C.T. Cowell Mutational analysis and genotype-phenotype correlation of the PHEX gene in X-linked hypophosphatemic rickets J. Clin. Endocrinol. Metab. 86 2001 3889 3899
14. S. Liu, R. Guo, Q. Tu, and L.D. Quarles Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype J. Biol. Chem. 277 2002 3686 3697
15. X. Coumoul, and C.X. Deng Roles of FGF receptors in mammalian development and congenital diseases Birth Defects Res. C Embryo. Today 69 2003 286 304
16. K.E. White, J.M. Cabral, S.I. Davis, T. Fishburn, W.E. Evans, and S. Ichikawa Mutations that Cause Osteoglophonic Dysplasia Define Novel Roles for FGFR1 in Bone Elongation Am. J. Hum. Genet. 76 2004 2
17. M. Mirams, B.G. Robinson, R.S. Mason, and A.E. Nelson Bone as a source of FGF23: regulation by phosphate? Bone 35 2004 1192 1199
18. R. Guo, S. Liu, R.F. Spurney, and L.D. Quarles Analysis of recombinant Phex: an endopeptidase in search of a substrate Am. J. Physiol. Endocrinol. Metab. 281 2001 E837 E847
19. A.E. Bowe, R. Finnegan, S.M. Jan de Beur, J. Cho, M.A. Levine, and R. Kumar FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate Biochem. Biophys. Res. Commun. 284 2001 977 981
20. A. Benet-Pages, B. Lorenz-Depiereux, H. Zischka, K.E. White, M.J. Econs, and T.M. Strom FGF23 is processed by proprotein convertases but not by PHEX Bone 35 2004 455 462
21. S. Liu, R. Guo, L.G. Simpson, Z.S. Xiao, C.E. Burnham, and L.D. Quarles Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX J. Biol. Chem. 278 39 2003 37419 37426
22. H. Saito, A. Maeda, S.I. Ohtomo, M. Hirata, K. Kusano, and S. Kato Circulating FGF-23 is regulated by 1a,25-dihydroxyvitamin D3 and phosphorus in vivo J. Biol. Chem. 279 2004 5
23. T. Shimada, H. Hasegawa, Y. Yamazaki, T. Muto, R. Hino, and Y. Takeuchi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis J. Bone Miner. Res. 19 2004 429 435
24. H. Saito, K. Kusano, M. Kinosaki, H. Ito, M. Hirata, and H. Segawa Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production J. Biol. Chem. 278 2003 2206 2211
25. T. Yamashita, M. Konishi, A. Miyake, K. Inui, and N. Itoh Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway J. Biol. Chem. 277 2002 28265 28270
26. P.S. Rowe, P.A. de Zoysa, R. Dong, H.R. Wang, K.E. White, and M.J. Econs MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia Genomics 67 2000 54 68
27. P.S. Rowe, Y. Kumagai, G. Gutierrez, I.R. Garrett, R. Blacher, and D. Rosen Mepe has the properties of an osteoblastic phosphatonin and minhibin Bone 34 2004 303 319
28. L.C. Gowen, D.N. Petersen, A.L. Mansolf, H. Qi, J.L. Stock, and G.T. Tkalcevic Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass J. Biol. Chem. 278 2003 1998 2007
29. T. Berndt, T.A. Craig, A.E. Bowe, J. Vassiliadis, D. Reczek, and R. Finnegan Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent J. Clin. Invest. 112 2003 785 794
30. T.O. Carpenter, B.K. Ellis, K.L. Insogna, W.M. Philbrick, J. Sterpka, and R. Shimkets FGF7 - an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors J. Clin. Endocrinol. Metab. 23 2004 23
31. T.J. Weber, S. Liu, O.S. Indridason, and L.D. Quarles Serum FGF23 levels in normal and disordered phosphorus homeostasis J. Bone Miner. Res. 18 2003 1227 1234
32. T. Shimada, M. Kakitani, Y. Yamazaki, H. Hasegawa, Y. Takeuchi, and T. Fujita Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism J. Clin. Invest. 113 2004 561 568
33. T. Larsson, R. Marsell, E. Schipani, C. Ohlsson, O. Ljunggren, and H.S. Tenenhouse Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis Endocrinol. 145 2004 3087 3094
34. Y. Kawakami, J. Capdevila, D. Buscher, T. Itoh, C. Rodriguez Esteban, and J.C. Izpisua Belmonte WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo Cell 104 2001 891 900
35. A. Gupta, K. Winer, M.J. Econs, S.J. Marx, and M.T. Collins FGF-23 is elevated by chronic hyperphosphatemia J. Clin. Endocrinol. Metab. 89 2004 4489 4492
36. L.M. Ward, F. Rauch, K.E. White, G. Filler, M.A. Matzinger, and M. Letts Resolution of severe, adolescent-onset hypophosphatemic rickets following resection of an FGF-23-producing tumour of the distal ulna Bone 34 2004 905 911
37. J.P. Salles, P. Moulin, J. Fauvel, F. Conte-Auriol, and M. Tauber FGF 23 levels are not modified during biphosphonate therapy in MacCune Albright syndrome with hypophosphatemia Horm. Res. 62 suppl 2 2004 43 (abstract)