Analysis of oxycodol and noroxycodol stereoisomers in biological samples by capillary electrophoresis

Electrophoresis

Volumn 26, Issue 10, 2005, Pages 1969-1977

  Baldacci, Andrea ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

6 Oxycodol diastereoisomers; Nor 6 oxycodol diasteroisomers; Oxycodone; Stereoselective drug metabolism; Stereoselective drug synthesis

Indexed keywords

FUSED SILICA; ISOMERS; METABOLISM; METABOLITES; SODIUM BOROHYDRIDE; STEREOSELECTIVITY; SYNTHESIS (CHEMICAL);

6-OXYCODOL DIASTEREOISOMER; DIASTEREOISOMERS; DRUG METABOLISMS; DRUG SYNTHESIS; NOR-6-OXYCODOL DIASTEROISOMER; OXYCODONE; STEREO-SELECTIVE; STEREOSELECTIVE DRUG METABOLISM; STEREOSELECTIVE DRUG SYNTHESIS;

CAPILLARY ELECTROPHORESIS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 6 OXYCODOL; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; BUFFER; CITALOPRAM; DIPYRONE; DRUG METABOLITE; MORPHINE; NOR 6 OXYCODOL; NOROXYCODONE; OPIATE DERIVATIVE; OXYCODONE; OXYMORPHONE; PHOSPHATE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DATA ANALYSIS; DIASTEREOISOMER; DOCUMENTATION; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIVER CYTOSOL; PH MEASUREMENT; RANDOMIZATION; SAMPLING; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STEREOCHEMISTRY; SULFATION; URINALYSIS;

EID: 20444416350     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.200410301     Document Type: Article

References (31)

1. Okuda, S., Yamaguchi, S., Kawazoe, Y., Tsuda, K., Chem. Pharm. Bull. 1964, 12, 104-112.
2. Kalso, E., Vainio, A., Clin. Pharmacol. Ther. 1990, 47, 639-646.
3. Leow, K. P., Smith, M. T., Williams, B., Cramond, T., Clin. Pharmacol. Ther. 1992, 52, 487-495.
4. Leow, K. P., Cramond, T., Smith, M. T., Anesth. Analg. 1995, 80, 296-302.
5. Hagen, N. A., Babul, N., Cancer 1997, 79, 1428-1437.
6. Davis, M. P., Varga, J., Dickerson, D., Walsh, D., LeGrand, S. B., Lagman, R., Support. Care Cancer 2003, 11, 84-92.
7. Moore, K. A., Ramcharitar, V., Levine, B., Fowler, D., J. Anal. Toxicol. 2003, 27, 346-352.
8. Ishida, T., Oguri, K., Yoshimura, H., Drug Metab. Dispos. 1979, 7, 162-165.
9. Weinstein, S. H., Gaylord, J. C., J. Pharm. Sci. 1979, 68, 527-528.
10. Ishida, T., Oguri, K., Yoshimura, H., J. Pharm. Dyn. 1982, 5, 521-525.
11. Pöyhiä, R., Seppälä, T., Olkkola, K. T., Kalso, E., Br. J. Clin. Pharmacol. 1992, 33, 617-621.
12. Kaiko, R. F., Benziger, D. P., Fitzmartin, R. D., Burke, B. E., Reder, R. F., Goldenheim, P. D., Clin. Pharmacol. Ther. 1996, 59, 52-61.
13. Lalovic, B., Kalhorn, T. F., Nelson, W. L., Shen, D. D., Congress of International Association for the Study of Pain, San Diego, CA, USA 2002.
14. Wey, A. B., Thormann, W., J. Chromatogr. B 2002, 770, 191-205.
15. Menelaou, A., Hutchinson, M. R., Quinn, I., Christensen, A., Somogyi, A. A., J. Chromatogr. B 2003, 785, 81-88.
16. Baldacci, A., Caslavska, J., Wey, A. B., Thormann, W., J. Chromatogr. A 2004, 1051, 273-282.
17. Lalovic, B., Phillips, B., Risler, L. L., Howald, W., Shen, D. D., Drug Metab. Dispos. 2004, 32, 447-454.
18. Ohara H., Miyabe, Y., Deyashiki, Y., Matsuura, K., Hara, A., Biochem. Pharmacol. 1995, 50, 221-227.
19. Ishida, T., Oguri, K., Yoshimura, H., J. Pharm. Dyn. 1982, 5, 134-136.
20. Meatherall, R., J. Anal. Toxicol. 1999, 23, 177-186.
21. Jones, J., Tomlinson, K., Moore, C., J. Anal. Toxicol. 2002, 26, 171-175.
22. Nowatzke, W., Zeng, J., Saunders, A., Bohrer, A., Koenig, J., Turk, J., J. Pharm. Biomed. Anal. 1999, 20, 815-828.
23. Dawson, M., Fryirs, B., Kelly, T., Keegan, J., Mather, L. E., J. Chromatogr. Sci. 2002, 40, 40-44.
24. Wright, A. W. E., Lawrence, J. A., lu, M., Cramond, T., Smith, M. T., J. Chromatogr. B 1998, 712, 169-175.
25. Smith, M. T., Watt, J. A., Mapp, G. P., Cramond, T., Ther. Drug Monit. 1991, 13, 126-130.
26. Zaugg, S., Thormann, W., J. Chromatogr. A 2000, 875, 27-41.
27. Hadley, M. R., Camilleri, P., Hutt, A. J., Electrophoresis 2000, 21, 1953-1976.
28. Prost, F., Thormann, W., Electrophoresis 2003, 24, 2577-2587.
29. Hahn, E. F., Fishman, J., J. Org. Chem. 1975, 40, 31-34.
30. Cherkaoui, S., Veuthey, J.-L., J. Pharm. Biomed. Anal. 2002, 27, 615-626.
31. Vincent, J. B., Sokolowski, A. D., Nguyen, T. V., Vigh, G., Anal. Chem. 1997, 69, 4226-4233.