A simpler and greener protocol for the preparation of β-acetylamino ketones by a one-pot reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile in the presence of zeolite Hβ as a reusable catalyst

Tetrahedron Letters

Volumn 46, Issue 28, 2005, Pages 4801-4803

  Bhat, Ramakrishna P ^a   Raje, Vivek P ^a   Alexander, Varughese M ^a   Patil, Sachin B ^a   Samant, Shriniwas D ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Acetylamino ketones; H catalyst; Multicomponent reaction; One pot synthesis

Indexed keywords

ACETIC ACID DERIVATIVE; ACETONITRILE; ALDEHYDE; AMINE; KETONE; ZEOLITE;

ARTICLE; CATALYST; CHEMICAL REACTION KINETICS; HIGH TEMPERATURE; ROOM TEMPERATURE; SYNTHESIS;

EID: 20444414513     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.05.018     Document Type: Article

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22. Experimental procedure: To a stirred mixture of zeolite Hβ (0.4 g) in acetonitrile (12.5 mL) were added an aldehyde (5 mmol), an enolisable ketone (5 mmol) and acetyl chloride (2 mL). The reaction mixture was stirred at 26-28°C for 8-12 h. The mixture was filtered to remove the catalyst and the filtrate was poured into ice-cold water and stirred for 20 min. The precipitated solid was filtered, dried, washed with petroleum ether 60-80°C to remove any residual starting material and dried. The products were characterised by their physical constants and spectral data
23. 1H NMR spectra were recorded using Varian 300 MHz spectrometer
24. -1. Mp of compounds (°C): 5a 190-191, 5b 114-115, 5c 134-136, 5d 150-152, 5e 109-111, 5f 128-130