Reversible impaired memory induced by pulsed methylprednisolone in patients with MS

Neurology

Volumn 64, Issue 11, 2005, Pages 1971-1973

  Uttner, I ^a,c   Muller S ^a   Zinser, C ^a   Maier, M ^a   Sussmuth S ^a   Claus, A ^a   Ostermann, B ^a   Elitok, E ^a   Ecker, D ^a   Brettschneider, J ^a   Gold, R ^b   Tumani, H ^a  

^a UNIVERSITY OF ULM   (Germany)

^b Gemeinnutzige Hertie Stiftung   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FOLLOW UP; HUMAN; LOW DRUG DOSE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MULTIPLE SCLEROSIS; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMORY DISORDERS; METHYLPREDNISOLONE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROSPECTIVE STUDIES;

EID: 20444393400     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000163804.94163.91     Document Type: Article

References (10)

1. Lupien SJ, McEwen BS. The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res Rev 1997;24:1-27.
2. DeQuervain DJ, Roozendaal B, Nitsch RM, McGaugh JL, Hock C. Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nat Neurosci 2000;3:313-314.
3. Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH. Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 1996;58:1475-1483.
4. Keenan PA, Jacobson MW, Soleymani RM, Mayes MD, Stress ME, Yaldoo DT. The effect on memory of chronic prednisone treatment in patients with systemic disease. Neurology 1996;47:1396-1402.
5. Oliveri RL, Valentino P, Russo C, et al. Randomized trial comparing two different high doses of methylprednisolone in MS: a clinical and MRI study. Neurology 1998;50:1833-1836.
6. Roozendaal B, DeQuervain DJ. Glucocorticoid therapy and memory function. Lessons learned from basic research. Neurology 2005;64:180-181.
7. Brunner R, Schaefer D, Hess K, Parzer P, Resch F, Schwab S. Effect of corticosteroids on short-term and long-term memory. Neurology 2005;64:335-337.
8. Oliveri RL, Sibilia G, Valentino P, Russo C, Romeo N, Quattrone A. Pulsed methylprednisolone induces a reversible impairment of memory in patients with relapsing-remitting multiple sclerosis. Acta Neurol Scand 1998;97:366-369.
9. Lupien SJ, Gillin CJ, Hauger RL. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav Neurosci 1999;113:420-430.
10. Foong J, Rozewicz L, Chong WK, Thompson AJ, Miller DH, Ron MA. A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis. J Neurol 2000;247:97-101.