Somatic symptoms in late-life anxiety: Treatment issues

Journal of Geriatric Psychiatry and Neurology

Volumn 18, Issue 2, 2005, Pages 89-96

  Lenze, Eric J ^a,c   Karp, Jordan F ^a   Mulsant, Benoit H ^a,b   Blank, Stephen ^d   Shear, M Katherine ^a   Houck, Patricia R ^a   Reynolds III, Charles F ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d NONE

Author keywords

Anxiety; Pain; Somatic symptoms; Treatment

Indexed keywords

AMFEBUTAMONE; ANTACID AGENT; BENZODIAZEPINE DERIVATIVE; CITALOPRAM; LOPERAMIDE; LORAZEPAM; MAGNESIUM HYDROXIDE; MYLANTA; PARACETAMOL; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; TRAZODONE;

ANORGASMIA; ANXIETY DISORDER; CLINICAL TRIAL; COMORBIDITY; CONFUSION; DYSPEPSIA; ERECTILE DYSFUNCTION; FALLING; FATIGUE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPOTHESIS; INSOMNIA; LIBIDO DISORDER; MEDICAL LITERATURE; META ANALYSIS; MIXED ANXIETY AND DEPRESSION; NAUSEA; OUTCOMES RESEARCH; PAIN; PRIORITY JOURNAL; PSYCHOTHERAPY; REVIEW; SEDATION; SIDE EFFECT; SOMATIC DELUSION; SOMATIZATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW;

AGE OF ONSET; AGED; ANXIETY DISORDERS; CITALOPRAM; FEMALE; HEALTH STATUS; HUMANS; MALE; MIDDLE AGED; PAIN; SEROTONIN UPTAKE INHIBITORS; SOMATOFORM DISORDERS; TREATMENT OUTCOME;

EID: 20444377739     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/0891988705276251     Document Type: Review

References (59)

1. Uhlenhuth EH, Balter MB, Mellinger GD, Cisin IH, Clinthorne J. Symptom checklist syndromes in the general population. Correlations with psychotherapeutic drug use. Arch Gen Psychiatry. 1983;40:1167-1173.
2. Lindesay J, Briggs K, Murphy E. The Guy's/Age Concern survey. Prevalence rates of cognitive impairment, depression and anxiety in an urban elderly community. Br J Psychiatry. 1989;155:317-329.
3. Manela M, Katona C, Livingston G. How common are the anxiety disorders in old age? Int J Geriatr Psychiatry. 1996;11:65-70.
4. Beekman AT, Bremmer MA, Deeg DJ, et al. Anxiety disorders in later life: a report from the Longitudinal Aging Study Amsterdam. Int J Geriatr Psychiatry. 1998;13:717-726.
5. Mulsant BH, Reynolds CF, Shear MK, Sweet RA, Miller MD. Comorbid anxiety disorders in late-life depression. Anxiety. 1996;2:242-247.
6. Lenze EJ, Mulsant BH, Shear MK, et al. Anxiety disorders in depressed elderly patients. Am J Psychiatry. 2000;15:722-728.
7. Alonso J, Angermeyer MC, Bernert S, et al. 12-Month comorbidity patterns and associated factors in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl. 2004;420:28-37.
8. Chambers JA, Power KG, Durham RC. The relationship between trait vulnerability and anxiety and depressive diagnoses at long-term follow-up of Generalized Anxiety Disorder. J Anxiety Disord. 2004;18:597-607.
9. Crum RM, Storr CL, Chan YF, et al. Sleep disturbance and risk for alcohol-related problems. Am J Psychiatry. 2004;161:1197-1203.
10. Pesa J, Lage MJ. The medical costs of migraine and comorbid anxiety and depression. Headache. 2004;33:562-570.
11. Poikolainen, K. Risk factors for alcohol dependence: a case-control study. Alcohol Alcohol. 2000;35:190-196.
12. Szanto K, Prigerson H, Houch P, et al. Suicidal ideation in elderly bereaved: the role of complicated grief. Suicide Life Threat Behav. 1997;27:194-207.
13. Shapiro S, Skinner EA, Kessler LG, et al. Utilization of health and mental health services. Three Epidemiologic Catchment Area sites. Arch Gen Psychiatry. 1984;41:971-978.
14. de Beurs E, van Balkom AJ, Van Dyck R, et al. Long-term outcome of pharmacological and psychological treatment for panic disorder with agoraphobia: a 2-year naturalistic follow-up. Acta Psychiatr Scand. 1999;99:59-67.
15. Golden AG, Preston RA, Barnett SD, et al. Inappropriate medication prescribing in homebound older adults. J Am Geriatr Soc. 1999;47:948-953.
16. Wijeratne C, Brodaty H, Hickie I. The neglect of somatoform disorders by old age psychiatry: some explanations and suggestions for future research. Int J Geriatr Psychiatry. 2003;18:812-819.
17. Sheehan B, Banerjee S. Review: somatization in the elderly. Int J Geriatr Psychiatry. 1999;14:1044-1049.
18. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association Press; 1994.
19. Young EA, Abelson JL, Cameron OG. Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol Psychiatry. 2004;56:113-120.
20. Stordal E, Bjelland I, Dahl AA, Mykletun A. Anxiety and depression in individuals with somatic health problems. The Nord-Trondelag Health Study (HUNT). Scand J Prim Health Care. 2003;21:136-141.
21. Haug TT, Mykletun A, Dahl AA. Are anxiety and depression related to gastrointestinal symptoms in the general population? Scand J Gastroenterol. 2002;37:294-298.
22. Eckhardt-Henn A, Breuer P, Thomalske C, Hoffmann SO, Hopf HC. Anxiety disorders and other psychiatric subgroups in patients complaining of dizziness. J Anxiety Disord. 2003;17:369-388.
23. Zwart JA, Dyb G, Hagen K, et al. Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. Eur J Neurol. 2003;10:147-152.
24. Wetherell JL, Thorp SR, Patterson TL, Golshan S, Jeste DV, Gatz M. Quality of life in geriatric generalized anxiety disorder: a preliminary investigation. J Psychiatr Res. 2004;38:305-312.
25. Casten RJ, Parmelee PA, Kleban MH, Lawton MP, Katz IR. The relationships among anxiety, depression, and pain in a geriatric institutionalized sample. Pain. 1995;61:271-276.
26. Creamer P, Lethbridge-Cejku M, Costa P, Tobin JD, Herbst JH, Hochberg MC. The relationship of anxiety and depression with self-reported knee pain in the community: data from the Baltimore Longitudinal Study of Aging. Arthritis Care Res. 1999;12:3-7.
27. Brouwer B, Musselman K, Culham E. Physical function and health status among seniors with and without a fear of falling. Gerontology. 2004;50:135-141.
28. Pletcher PC, Hirdes JP. Restriction in activity associated with fear of falling among community-based seniors using home care services. Age Ageing. 2004;33:273-279.
29. Naik AD, Concato J, Gill TM. Bathing disability in community-living older persons: common, consequential, and complex. J Am Geriatr Soc. 2004;52:1805-1810.
30. Schappert SM. National Ambulatory Medical Care Survey: 1989 summary. Vital Health Stat. 1992;13(110):1-80.
31. Kroenke K, Jackson JL, Chamberlin J. Depressive and anxiety disorders in patients presenting with physical complaints: clinical predictors and outcome. Am J Med. 1997;103:339-347.
32. Jackson JL, Houston JS, Hanling SR, Terhaar KA, Yun JS. Clinical predictors of mental disorders among medical outpatients. Arch Intern Med. 2001;161:875-879.
33. Borkovec TD, Robison E, Pruzinsky T, DePree JA. Preliminary exploration of worry: some characteristics and processes. Behav Res Ther. 1983;21:9-16.
34. Keefe F, Brown G, Wallston KA, Caldwell DS. Coping with rheumatoid arthritis: catastrophizing as a maladaptive strategy. Pain. 1989;37:51-56.
35. Turner JA, Jensen MP, Romano JM. Do beliefs, coping, and catastrophizing independently predict functioning in patients with chronic pain? Pain. 200;85:115-125.
36. Wetherell JL, Kaplan RM, Kallenberg G, Dresselhaus TR, Sieber WJ, Lang AJ. Mental health treatment preferences of older and younger primary care patients. Int J Psychiatry Med. 2004;34:219-233.
37. Harman JS, Rollman BL, Hanusa BH, Lenze EJ, Shear MK. Physician office visits of adults for anxiety disorders in the United States: 1985-1998. J Gen Intern Med. 2002;17:165-172.
38. Lenze EJ, Pollock BG, Shear MK, Mulsant BH, Bharucha A, Reynolds CF. Treatment considerations for anxiety in the elderly. CNS Spectr. 2003;8:6-13.
39. Wetherell JL, Gatz M, Craske MG: Treatment of generalized anxiety disorder in older adults. J Consult Clin Psychol. 2003;71:31-40.
40. Katz IR, Reynolds CP, Alexopoulos GS, Hackett D. Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials. J Am Geriatr Soc. 2002;50:18-24.
41. Lenze EJ, Mulsant BH, Dew MA, et al: Good treatment outcomes in late-life depression with comorbid anxiety. J Affect Disord. 2003;77:247-254.
42. Mulsant BH, Pollock BG, Nebes R, et al. A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients. Am J Geriatr Psychiatry. 2001;9:406-414.
43. Lenze EJ, Blank S, Houck P, Mulsant BH, Shear MK, Reynolds CF. Treatment of anxiety disorders in elderly: a 32-week trial of citalopram. Paper presented at: Annual Meeting of the Anxiety Disorders Association of America; 2005; Seattle, Wash.
44. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32:50-55.
45. Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl. 1987;334:1-100.
46. Fava M. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. J Clin Psychiatry. 2003;64:26-29.
47. Fava M, Mallinckrodt CH, Detke MJ, Watkin JG, Wohlreich MM. The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates? J Clin Psychiatry. 2004;65:521-530.
48. Dunner DL, Goldstein DJ, Mallinckrodt C, Lu Y, Detke MJ. Duloxetine in treatment of anxiety symptoms associated with depression. Depress Anxiety. 2003;18:53-61.
49. Schatzberg AF, Kremer C, Rodrigues HE, Murphy GM Jr. Mirtazapine vs. Paroxetine Study Group. Double-blind, randomized comparison of mirtazapine and paroxetine in elderly depressed patients. Am J Geriatr Psychiatry. 2002;10:541-550.
50. Taylor K, Rowbotham MC. Venlafaxine hydrochloride and chronic pain. West J Med. 1996;165:147-148.
51. Yilmaz ME, Kadiroglu AK, Kara IH, Dikici S. Venlafaxine in the treatment of painful peripheral diabetic neuropathy in a uremic patient undergoing hemodialysis. MedGenMed. 2002;4:23.
52. Oslin DW, Ten Have TR, Streim JE, et al. Probing the safety of medications in the frail elderly: evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents. J Clin Psychiatry. 2003;64:875-882.
53. Harrison CL, Ferrier N, Young AH. Tolerability of high-dose venlafaxine in depressed patients. J Psychopharmacol. 2004;18:200-204.
54. Wagner AK, Zhang F, Soumerai SB, et al. Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med. 2004;164:1567-1572.
55. Stanley MA, Diefenbach GJ, Hopko DR. Cognitive behavioral treatment for older adults with generalized anxiety disorder: a therapist manual for primary care settings. Behav Modif. 2004;28:73-117.
56. Wetherell JL, Sorrell JT, Thorp SR, Patterson TL. Psychological interventions for late-life anxiety: a review and early lessons from the CALM study. J Geriatr Psychiatry Neurol. 2005;18:72-82.
57. Orsillo SM, Roemer L, Barlow DH. Integrating acceptance and mindfulness into existing cognitive-behavioral treatment for GAD: a case study. Cognit Behav Pract. 2003;10:222-230.
58. Kroenke K. Patients presenting with somatic complaints: epidemiology, psychiatric comorbidity and management. Int J Methods Psychiatr Res. 2003;12:34-43.
59. Mulsant BH, Pollock BG, Kirshner M, Shen C, Dodge H, Ganguli M. Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance. Arch Gen Psychiatry. 200;60:198-203.