New local anesthetics for pediatric anesthesia

Current Opinion in Anaesthesiology

Volumn 18, Issue 3, 2005, Pages 289-292

  De Negri, Pasquale ^a   Ivani, Giorgio ^a   Tirri, Tiziana ^a   Del Piano, Anna Claudia ^a  

^a REFERRAL CANCER CENTER OF BASILICATA   (Italy)

Author keywords

Levobupivacaine; Local anesthetics; Ropivacaine

Indexed keywords

ADJUVANT; ADRENALIN; ALBUMIN; AMIDE; ANALGESIC AGENT; BUPIVACAINE; CHOLINESTERASE; CLONIDINE; CYTOCHROME P450 1A2; ESTER DERIVATIVE; FENTANYL; KETAMINE; LEVOBUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; OROSOMUCOID; PARACETAMOL; PLASMA PROTEIN; ROPIVACAINE; TERTIARY AMINE; TRAMADOL;

ANESTHESIA INDUCTION; ANESTHESIA LEVEL; CARDIOTOXICITY; CLINICAL TRIAL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INFUSION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG UTILIZATION; ENANTIOMER; HUMAN; ISOMER; LOCAL ANESTHESIA; NEUROTOXICITY; PEDIATRIC ANESTHESIA; PHARMACOKINETICS; PRACTICE GUIDELINE; PRIORITY JOURNAL; REGIONAL ANESTHESIA; REVIEW;

EID: 20444376534     PISSN: 09527907     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aco.0000169237.29303.00     Document Type: Review

References (24)

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2. Wood CE, Goresky GV, Klassen KA, et al. Complications of continuous epidural infusions for postoperative analgesia in children. Can J Anaesth 1994; 41:613-620.
3. Zink W, Graf BM. Benefit-risk assessment of ropivacaine in the management of postoperative pain. Drug Saf 2004; 27:1093-1114. A review of benefit-risk assessment of ropivacaine used for postoperative pain treatment.
4. Mazoit JX, Dalens BJ. Pharmacokinetics of local anaesthetics in infants and children. Clin Pharmacokinet 2004; 43:17-32. A review of the pharmacokinetics of local anesthetics commonly used in children.
5. Nava-Ocampo AA, Bello-Ramirez AM. Lipophilicity affects the pharmacokinetics and toxicity of local anaesthetic agents administered by caudal block. Clin Exp Pharmacol Physiol 2004; 31:116-118. An interesting study on the pharmacokinetics of ropivacaine and bupivacaine administered caudally.
6. De Negri P, Ivani G, Tirri T, et al. A comparison of epidural bupivacaine, levobupivacaine, and ropivacaine on postoperative analgesia and motor blockade. Anesth Analg 2004; 99:45-48. This is actually the only prospective, randomized, observer-blinded clinical trial conducted in children addressing a comparison of different local anesthetic epidurally administered in continuous infusion for postoperative pain.
7. Gunes Y, Secen M, Ozcengiz D, et al. Comparison of caudal ropivacaine, ropivacaine plus ketamine and ropivacaine plus tramadol administration for postoperative analgesia in children. Paediatr Anaesth 2004; 14:557-563. The study compares the effect of caudal anesthetic alone or in conjunction with adjuvants in children for postoperative pain management.
8. Tsuchiya N, Ichizawa M, Yoshikawa Y, et al. Comparison of ropivacaine with bupivacaine and lidocaine for ilioinguinal block after ambulatory inguinal hernia repair in children. Paediatr Anaesth 2004; 14:468-470. The study compares ropivacaine with bupivacaine and lidocaine for ilioinguinal block used for ambulatory inguinal hernia repair.
9. Park AH, Pappas AL, Fluder E, et al. Effect of perioperative administration of ropivacaine with epinephrine on postoperative pediatric adenotonsillectomy recovery. Arch Otolaryngol Head Neck Surg 2004; 130:459-464. This paper determines the pharmacokinetics and the ability of perioperative administration of ropivacaine with vasoconstrictors to decrease postoperative pain following adenotonsillectomy.
10. Paul O, Schreiber E, Lacroix F, et al. High plasma ropivacaine concentrations after fascia iliaca compartment block in children. Br J Anaesth 2004; 92:416-418. This paper studies how the mode of administration can influence the pharmacokinetic profile of local anaesthetics.
11. Shimoda T, Sasaoka N, Yamaguchi A, et al. Ilioinguinal/iliohypogastric nerve block for pediatric inguinal herniorrhaphy; evaluation of the dose of ropivacaine. Masui 2004; 53:1259-1262.
12. Duflo F, Qamouss Y, Remond C, et al. Patient-controlled regional analgesia is effective in children: a preliminary report. Can J Anaesth 2004; 51:928-930. This is a report about the use of patient-controlled regional analgesia using ropivacaine for postoperative pain control following lower limb surgery.
13. de Jose Maria B, Tielens LK. Vertical infraclavicular brachial plexus block in children: a preliminary study. Paediatr Anaesth 2004; 14:931-935. This an interesting study determining the ease, effectiveness, safety and duration of infraclavicular block with ropivacaine.
14. Sakellaris G, Petrakis I, Makatounaki K, et al. Effects of ropivacaine infiltration on cortisol and prolactin responses to postoperative pain after inguinal hernioraphy in children. J Pediatr Surg 2004; 39:1400-1403. This study evaluates the effects of infiltration of the surgical area with ropivacaine on postoperative pain and hormonal responses.
15. Rapp HJ, Molnar V, Austin S, et al. Ropivacaine in neonates and infants: a population pharmacokinetic evaluation following single caudal block. Paediatr Anaesth 2004; 14:724-732. The authors evaluate pharmacokmetics, efficacy and safety of ropivacaine in infants aged 0-12 months.
16. Aguirre-Garay FT, Garcia R, Nava-Ocampo AA. Dose-response of ropivacaine administered caudally to children undergoing surgical procedures under sedation with midazolam. Clin Exp Pharmacol Physiol 2004; 31: 462-465.
17. Ivani G, Tonetti F. Postoperative analgesia in infants and children: new developments. Minerva Anestesiol 2004; 70:399-403. This is a review of continuous peripheral nerve blocks with new local anaesthetics.
18. Lacroix F, Meyrieux V, De Franceschi E, et al. Efficacy of continuous peripheral nerve block with ropivacaine 0.2% in children after major lower limb surgery: a prospective randomized controlled study [abstract]. Anesthesiology 2004; 101:1507.
19. Matsota P, Papageorgiou-Brousta M. Intraoperative and postoperative analgesia with subcutaneous ring block of the penis with levobupivacaine for circumcision in children. Eur J Pediatr Surg 2004; 14:198-202. This study evaluates the efficacy of ring block of the penis in preventing intraoperative and postoperative pain associated with circumcision in children and the quality of the recovery.
20. Chalkiadis GA, Eyres RL, Cranswick N, et al. Pharmacokinetics of levobupivacaine 0.25% following caudal administration in children under 2 years of age. Br J Anaesth 2004; 92:218-222. This paper examines the pharmacokinetics of levobupivacaine after single-shot caudal epidural administration.
21. Kokki H, Ylonen P, Heikkinen M, et al. Levobupivacaine for pediatric spinal anesthesia. Anesth Analg 2004; 98:64-67. This clinical trial evaluates the clinical effects of levobupivacaine in spinal anesthesia in children.
22. Frawley GP, Farrell T, Smith S. Levobupivacaine spinal anesthesia in neonates: a dose range finding study. Paediatr Anaesth 2004; 14:838-844. This is an interesting study that determines the clinical efficacy and the minimum local analgesic dose of levobupivacaine for spinal anesthesia in ex-premature babies.
23. Ivani G, L'Erario M, Mossetti V, et al. Ropivacaine vs Levobupivacaine in pediatric caudal anesthesia [abstract]. Anesthesiology 2004; 101: A1478.
24. Locatelli B, Ingelmo P, Sonzogni V, et al. Randomized, double-blind, phase III, controlled trial comparing levobupivacaine 0.25%, ropivacaine 0.25% and bupivacaine 0.25% by the caudal route in children. Br J Anaesth Advance Access [published on 17 December 2004; DOI 10.1093/bja/aei059]. The paper compares the efficacy and the duration of different local anaesthetics administered by single caudal shot.