The construction of an adenovirus vector containing cytosine deaminase gene and its application

Acta Biochimica et Biophysica Sinica

Volumn 30, Issue 2, 1998, Pages 167-168

  Xu, De Hua ^a   Ge, Kai ^a   Jian, Qiong ^a   Zheng, Zhong Cheng ^a   Liu, Xin Yuan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Adenovirus vector; Cancer; Cd gene; Gene therapy

Indexed keywords

EID: 20444370314     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

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2. Huber B E, Austin E A, Good S S et al. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res, 1993, 53: 4619-4626
3. Mullen C A, Coale M M, Lowe R et al. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. Cancer Res, 1994, 54: 1503-1506
4. ((Jiang Q, Ge K, Xu D H et al.): (Acta Biochimica et Biophysica Sinica), 1997, 29: 135-141
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6. Austin E A and Huber B E. A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing and expression of Escherichia coli cytosine deaminase. Mol Pharmacol, 1993, 43: 380-387
7. Ge K, Xu L F, Zheng Z C et al. Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine. Inter J Cancer, 1997, 71: 675-679
8. Huber B E, Austin E A, Richards C A et al. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA, 1994, 91: 8302-8306