Immediate or delayed radiotherapy in advanced non-small cell lung cancer (NSCLC)? Data from a prospective randomised study

Radiotherapy and Oncology

Volumn 75, Issue 2, 2005, Pages 141-148

  Sundstrøm, Stein ^a,b   Bremnes, Roy ^c,d   Brunsvig, Paal ^e   Aasebø, Ulf ^c,d   Klepp, Olbjørn ^a,b   Fayers, Peter M ^b,f   Kaasa, Stein ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

^d UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Immediate treatment; Lung cancer; NSCLC; Palliative radiotherapy; Quality of life

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXPERIENCE; FEMALE; FRACTIONATION; HEALTH CARE POLICY; HUMAN; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL ANALYSIS; STRATIFICATION; SYMPTOM;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; DOSE FRACTIONATION; FEMALE; HEALTH STATUS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PALLIATIVE CARE; PROSPECTIVE STUDIES; QUALITY OF LIFE; TIME FACTORS;

EID: 20444364830     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2005.03.028     Document Type: Article

References (25)

1. T. Akechi, H. Okamra, Y. Nishiwaki, and Y. Uchitomi Psychiatric disorders and associated and predictive factors in patients with unresectable nonsmall cell lung carcinoma Cancer 92 2001 2609 2622
2. N.K. Aaronson, S. Ahmedzai, and B. Bergmann The European organization for research and treatment of Cancer QLQ-C-30: a quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 85 1993 365 376
3. B. Bergmann, N.K. Aaronson, S. Ahmedzai, S. Kaasa, and M. Sullivan The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life Eur J Cancer 30A 1994 635 642
4. J. Bernhard, and P.A. Ganz Psychosocial issues in Lung Cancer Patients (part 1) Chest 99 1991 216 223
5. R.E. Brashear Should asymptomatic patients with inoperable bronchogenic carcinoma receive immediate radiotherapy? No Am Rev Respir Dis 117 1978 411 414
6. M. Carrol, S.A. Morgan, J.R. Yarnold, J.M. Hill, and N.M. Wright Prospective evaluation of a watch policy in patients with inoperable non-small cell lung Cancer Eur J Cancer Clin Onc 22 1986 1353 1356
7. M.H. Cohen Is immediate radiation therapy indicated in patients with unresectable non-small cell lung cancer? No Cancer Treat Rep 67 1983 333 336
8. T.M. Collins, D.V. Ash, H.J. Close, and J. Thorogood An evaluation of the palliative role of radiotherapy in inoperable carcinoma of the bronchus Clin Radiol 39 1988 284 286
9. J.D. Cox, R. Komaki, and R.W. Byhardt Is immediate chest radiotherapy obligatory for any patients with limited-stage non-small cell carcinoma of the lung? Yes Cancer Treat Rep 67 1983 327 331
10. M. Cullen Lung cancer: chemotherapy for non-small cell lung cancer: the end of beginning Thorax 58 2003 352 356
11. K.R. Durrant, F. Ellis, J.M. Black, R.J. Berry, F.R. Ridehalgh, and W.S. Hamilton Comparison of treatment policies in inoperable bronchial carcinoma Lancet 10 1971 715 719
12. S.J. Falk, D.J. Girling, R.J. White, and On behalf of the Medical Research Council Lung Cancer Working Party Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomised controlled trial Br Med J 325 2002 465 468
13. Fayers PM, Aaronson N, Bjordal K, Sullivan Ml. EORTC QLQ-C30 Scoring Manual, On behalf of EORTC Quality of Life Study Group, Brussels; 1995.
14. M.T. King Interpreting of scores from the EORTC quality of life questionnaire QLQ-C30 Qual Life Res 5 1996 555 567
15. S. Kaasa, and A. Mastekaasa Psychosocial well-being of patients with inoperable non-small cell lung cancer Acta Oncol 27 1988 829 835
16. J.A. Langendijk, G.P.M. Ten Velde, N.K. Aaronson, J.M.A. De Jong, M.J. Muller, and E.F.M. Wouters Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study Int J Radiat Oncol Biol Phys 1 2000 149 155
17. F. Macbeth, J.J. Bolger, and P. Hopwood Randomised trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status. Medical Research Council Lung Cancer Working Party Clin Oncol (R Coll Radiol) 8 1996 167 175
18. F. Macbeth, E. Toy, B. Coles, A. Melville, and A. Eastwood Palliative radiotherapy regimens for non-small cell lung cancer Cochrane Database Syst Rev 1 2002 CD002143
19. C.F. Mountain A new international staging system for lung cancer Chest 89 1986 225S 233S
20. D. Osoba, G. Rodrigues, J. Myles, B. Zee, and J. Pater Interpreting the significance of changes in Health-Related Quality-of-Life Scores J Clin Oncol 16 1998 139 144
21. T.L. Philips, and R.J. Miller Should asymptomatic patients with inoperable bronchogenic carcinoma receive immediate radiotherapy? Yes Am Rev Respir Dis 117 1978 405 410
22. J.R. Simpson, M.E. Francis, R. Perez-Tamayo, R.D. Marks, and D.V. Rao Palliative radiotherapy for inoperable carcinoma of the lung: final Report of a RTOG multi-institutional trial Int J Radiat Onc Biol Phys 11 1985 751 758
23. S. Sundstrøm, R.M. Bremnes, and U. Aasebø Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial J Clin Oncol 22 2004 801 810
24. E. Toy, F. Macbeth, B. Coles, and A.L. Eastwood Palliative thoracic radiotherapy for non-small-cell lung cancer. A systematic review Am J Clin Oncol 26 2003 112 120
25. Histological typing of lung and pleural tumour 3rd ed. 1999 Springer Geneva, Switzerland