Flunarizine and cinnarizine-induced parkinsonism: A historical and clinical analysis

Parkinsonism and Related Disorders

Volumn 10, Issue 4, 2004, Pages 243-245

  Teive, Hélio A G ^a   Troiano, André R ^a   Germiniani, Francisco M B ^a   Werneck, Lineu C ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Cinnarizine; Flunarizine; Parkinsonism

Indexed keywords

ANTIEMETIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CINNARIZINE; DILTIAZEM; FLUNARIZINE; NEUROLEPTIC AGENT;

AKATHISIA; ANXIETY; BRADYKINESIA; CLINICAL FEATURE; DEPRESSION; DROWSINESS; DYSTONIA; EXTRAPYRAMIDAL SYMPTOM; FACIAL HYPOMIMIA; FACIAL TREMOR; HUMAN; INSOMNIA; LITERATURE; MOTOR COORDINATION; MUSCLE RIGIDITY; MUSCLE WEAKNESS; PARKINSONISM; PRIORITY JOURNAL; REVIEW; SEDATION; SIDE EFFECT;

EID: 2042509031     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2003.12.004     Document Type: Article

References (17)

1. Stacy M., Jankovic J. Cedarbaum J.M., Gancher S.T. Differential diagnosis of Parkinson's disease and the Parkinson's plus syndromes. Neurologic Clinics. Parkinson's Disease. vol. 10(2):1992;341-349 W.B. Saunders, Philadelphia
2. Riley D.E. Secondary parkinsonism. Jankovic J., Tolosa E. Parkinson's disease and movement disorders. 3rd ed. 1998;317-339 Williams and Wilkins, Baltimore, MD
3. Llau M.E., Nguyen L., Senard J.M., Rascol O., Montastruc J.L. Drug-induced parkinsonian syndromes: a 10-year experience at a regional center of pharmaco-vigilance. Rev Neurol. 50:1994;757-762
4. Kuzuhara S. Drug-induced parkinsonism. Nippon Rinsho. 55:1997;112-117
5. Errea-Abad J.M., Ara-Callizo J.R., Aibar-Remon C. Drug-induced parkinsonism. Clinical aspects compared with Parkinson's disease. Rev Neurol. 27:1998;35-39
6. Chouza C., Scaramelli A., Caamanõ J.L., De Medina O., Aljanati R., Romero S. Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine. Lancet. 1:1986;1303-1304
7. Micheli F., Pardal M.F., Gatto M., Torres M., Paradiso G., Parera I.C., Giannaula R. Flunarizine- and cinnarizine-induced extrapyramidal reactions. Neurology. 37:1987;881-884
8. Negrotti A., Calzetti S. A long-term follow-up study of cinnarizine-and flunarizine-induced parkinsonism. Mov Disord. 12:1997;107-110
9. Martí-Massó J., Poza J.J. Cinnarizine-induced parkinsonism: ten years later. Mov Disord. 13:1998;453-456
10. Gimenéz-Roldàn S., Mateo D. Cinnarizine-induced parkinsonism: susceptibility related to aging and essential tremor. Clin Neuropharmacol. 14:1991;156-164
11. De Melo-Souza SE. Flunarizina, Parkinsonismo e Depressão. XI Congresso Brasileiro de Neurologia (Resumos), Goiânia, Brasil; 1984.
12. De Melo-Souza S.E., Ragazzo P.C. Neurologic side effects of flunarizine. Neurology. 39:(Suppl 1):1989;390
13. Martí-Massó J.F., Carrera N., de La Puente E. Posible parkinsonismo inducido por cinaricina. Medicina Clínica (Barcelona). 85:1985;614-616
14. Bezerra JMF. Síndrome Parkinsoniana Induzida por Flunarizina e/ou Cinarizina. Thesis. Federal University of São Paul, São Paulo; 1993.
15. Mena M.A., Garcia de Yébenes M.J., Tabernero C., Casarejos M.J., Pardo B., Garcia de Yébenes J. Effects of calcium antagonists on the dopamine system. Clin Neuropharmacol. 18:1995;410-426
16. Cardoso F., Camargo S.T., Silva G.A. Jr. Etiology of parkinsonism in a Brazilian movement disorders clinic. Arq Neuropsiquiatr. 56:1998;171-175
17. Micheli F., Pardal M.M., Giannaula R., Gatto M., Parera I., Paradiso G., Torres M., Pikielny R., Pardal J. Movement disorders and depression due to flunarizine and cinnarizine. Mov Disord. 4:1989;139-146