Microdissection-Based Genotyping Assists Discrimination of Reactive Gliosis from Glioma

American Journal of Clinical Pathology

Volumn 121, Issue 5, 2004, Pages 671-678

  Finkelstein, Sydney D ^a,d   Mohan, Deepak ^a,c   Hamilton, Ronald L ^a   Sasatomi, Eizaburo ^a   Swalsky, Patricia A ^a,d   Lieberman, Frank S ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d RedPath Integrated Pathology   (United States)

Author keywords

Glioma; Gliosis; LOH; Loss of heterozygosity; Microdissection; Molecular anatomic pathology; Molecular genotyping; Mutation; PCR; Polymerase chain reaction

Indexed keywords

DNA; OLIGONUCLEOTIDE; RNA;

ARTICLE; BRAIN TUMOR; CYTOGENETICS; DIFFERENTIAL DIAGNOSIS; GENE MUTATION; GENOTYPE; GLIOMA; GLIOSIS; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICRODISSECTION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 2042460882     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/WF2HL03T7YP713NK     Document Type: Article

References (15)

1. Nishioka H, Ito H, Miki T. Difficulties in the antemortem diagnosis of gliomatosis cerebri: report of a case with diffuse increase of gemistocyte-like cells, mimicking reactive gliosis. Br J Neurosurg. 1996;10:103-107.
2. Schiffer D, Cavalla P, Dutto A, et al. Cell proliferation and invasion in malignant gliomas. Anticancer Res. 1997;17:61-69.
3. Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 2002;61:215-225.
4. Simmons ML, Lamborn KR, Takahashi M, et al. Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res. 2001;61:1122-1128.
5. Pollack IF, Biegel J, Yates A, et al. Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classification. Curr Oncol Rep. 2002;4:114-122.
6. Sallinen SL, Sallinen PK, Haapasalo HK, et al. Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res. 2000;60:6617-6622.
7. Koschny R, Koschny T, Froster UG, et al. Comparative genomic hybridization in glioma: a meta-analysis of 509 cases. Cancer Genet Cytogenet. 2002;135:147-159.
8. Rohlff C, Southan C. Proteomic approaches to central nervous system disorders. Curr Opin Mol Ther. 2002;4:251-58.
9. Pollack IF, Hamilton RL, Finkelstein SD, et al. The relationship between mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. Cancer Res. 1997;57:304-309.
10. Finkelstein SD, Przygodzki RM, Pricolo VE, et al. Prediction of biological aggressiveness in colorectal cancer by p53/K-ras-2 topographic genotyping. Mol Diagn. 1996;1:5-28.
11. Finkelstein SD, Przygodzki R, Swalsky PA. Microdissection-based p53 genotyping: concepts for molecular testing. Mol Diagn. 1998;3:179-191.
12. Finkelstein SD, Marsh W, Demetris AJ, et al. Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma. Hepatology. 2003;37:871-879.
13. Lawrie LC, Curran S, McLeod HL, et al. Application of laser capture microdissection and proteomics in colon cancer. Mol Pathol. 2001;54:253-258.
14. Rolston R, Sasatomi S, Hunt J, et al. Distinguishing de novo second cancer formation from tumor recurrence: mutational fingerprinting by microdissection genotyping, J Mol Diagn. 2001;3:129-132.
15. Dreesen JC, Bras M, Coonen E, et al. Allelic dropout caused by allele-specific amplification failure in single-cell PCR of the cystic fibrosis delta F508 deletion. J Assist Reprod Genet. 1996;13:112-114.