Effect of I1 Imidazoline Receptor Agonist, Moxonidine, in Nitric Oxide-Deficient Hypertension in Pregnant Rats

Journal of Cardiovascular Pharmacology

Volumn 43, Issue 5, 2004, Pages 731-736

  Gairard, Alexis ^a,d   Lopez Miranda, Visitacion ^b   Pernot, Fanny ^a   Beck, Jean F ^a   Coumaros, Geneviève ^a   Van Overloop, Bruno ^e   La Roche, Benoit ^c   Koehl, Christian ^a   Christen, Marie O ^c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSIDAD REY JUAN CARLOS   (Spain)

^c Laboratoires Solvay Pharma   (France)

^d CNRS   (France)

^e Université Louis Pasteur ^*

Author keywords

Glucose tolerance; Moxonidine; NO synthase inhibition; Preeclampsia; Rat

Indexed keywords

ANTIHYPERTENSIVE AGENT; GLUCOSE; IMIDAZOLINE I1 RECEPTOR; INSULIN; MOXONIDINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENTOBARBITAL; DRUG RECEPTOR; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTORS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; FETUS; FETUS NECROSIS; FETUS OUTCOME; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; NECROSIS; NONHUMAN; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; RAT; RAT STRAIN; ANIMAL; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG POTENTIATION; EATING; MATERNAL HYPERTENSION; METABOLISM; PATHOLOGY; WEIGHT GAIN; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; EATING; FEMALE; FETUS; GLUCOSE TOLERANCE TEST; HYPERTENSION, PREGNANCY-INDUCED; IMIDAZOLES; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, DRUG; WEIGHT GAIN;

EID: 2042454164     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200405000-00017     Document Type: Article

References (28)

1. Gant NF, Daley GF, Whalley PJ, et al. A study of angiotensin 11 pressor responses throughout primigravid pregnancy. J Clin Invest. 1973;52: 2682-2689.
2. Schobel HP, Fischer T, Heuszer K, et al. Preeclampsia: a state of sympathetic overactivity. N Engl J Med. 1996;335:1480-1485.
3. Morris NH, Eaton BM, Dekker G. Nitric oxide, the endothelium, pregnancy and pre-eclampsia. Br J Pharmacol. 1996;103:4-15.
4. Cuna RS, Cabral AM, Vasquez EC. Evidence that autonomic nervous system plays a major role in the L-NAME induced hypertension in conscious rats. Am J Hypertens. 1993;6:806-809.
5. Sander M, Hansen J, Victor RG. The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by Nω-nitro-L-arginine methyl ester. Hypertension. 1997;30:64-70.
6. Baylis C, Engels K. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat [part B Hypertension in pregnancy]. Clin Exp Hypertens. 1992;11:117-129.
7. Van Overloop B, Pernot F, Houllé V, et al. Inhibition of nitric oxide synthesis and in vitro vascular reactivity in pregnant rats. Fund Clin Pharmacol. 1993;7:183.
8. Yallampalli C, Izumi H, Byam-Smith M, et al. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol. 1993;169:1316-1320.
9. Helmbrecht GD, Farhat MY, Lockbaum L, et al. L-arginine reverses the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat. Am J Obstet Gynecol. 1996;175:800-805.
10. Schaefer SG, Kaan EC, Christen MO, et al. Why imidazoline receptor modulator in the treatment of hypertension? Ann N Y Acad Sci. 1995;763: 659-672.
11. Solomon CG, Carroll JS, Okamura K, et al. Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension. Am J Hypertens. 1999;12:276-282.
12. Sowers JR, Saleh AA, Sokol RJ. Hyperinsulinemia and insulin resistance are associated with preeclampsia in African Americans. Am J Hupertens. 1995;8:1-4.
13. Rösen P, Ohly P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. J Hypertens. 1997;15(suppl 1):1993-1999.
14. Dieye AM, Van Overloop B, Gairard A. Endothelin-1 and relaxation of the rat aorta during pregnancy in nitroarginine-induced hypertension. Fund Clin Pharmacol. 1999;13:204-212.
15. Podjarny E, Benchetrit S, Katz B, et al. Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. Nephron. 2001;88:354-359.
16. Richer C, Boulanger H, Es-Slami S, et al. Lack of beneficial effects of the NO donor molsidomine in the L-NAME induced pre-eclamptic syndrome in pregnant rats. Br J Pharmacol. 1996;119:1642-1648.
17. Wight E, Küng CF, Moreau P, et al. Chronic blockade of nitric oxide synthase and endothelin receptors during pregnancy in the rat: effect on pregnancy outcome. J Soc Gynecol Invest. 1998;5:132-139.
18. Thaete LG, Neerhof MG. Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension. Hypertens Preg. 2000;19:233-247.
19. Khatun S, Kanayama N, Sato E, et al. Eclamptic plasma stimulates norepinephrine release in cultured sympathetic nerve. Hypertension. 1998; 31:1343-1349.
20. Greenwood JP, Stoker JB, Walker JJ, et al. Sympathetic nerve discharge in normal pregnancy and pregnancy-induced hypertension. J Hypertens. 1998;16:617-624.
21. Bousquet P. Identification and Characterization of 11 imidazoline receptors: their role in blood pressure regulation. Am J Hypertens. 2000;13: 84S-88S.
22. Navarro J, Sanchez A, Sais J, et al. Hormonal, renal and metabolic alterations during hypertension induced by chronic inhibition of NO in rats. Am J Physiol. 1994;267:R1516-R1521.
23. Pueyo ME, Gonzalez W, Pussard E, et al. Insulin secretion in rats with chronic nitric oxide synthase blockade. Diabetologia. 1994;37:879-884.
24. Ernsberger P, Ishizuka T, Liu S, et al. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB). J Pharmacol Exp Ther. 1999;288:139-147.
25. Panagiotidis G, Akesson B, Rydell EL, et al. Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide, on insulin release induced by various secretagogues. Br J Pharmacol. 1995;114:289-296.
26. Henriksen EJ, Jacob S, Fogt DL, et al. Antihypertensive agent moxonidine enhances muscle glucose transport in insulin-resistant rats. Hypertension. 1997;30:1560-1565.
27. Bock JU, Van Zwieten PA. The central hyperglycemic effect of clonidine. Eur J Pharmacol. 1971;16:303-310.
28. 1-imidazoline and α2-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. J Pharmacol Exp Ther. 2003;306:646-657.