Effect of particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling on cohesiveness

Journal of Pharmaceutical Sciences

Volumn 94, Issue 5, 2005, Pages 1004-1012

  Fukunaka, Tadashi ^a   Sawaguchi, Kohta ^b   Golman, Boris ^b   Shinohara, Kunio ^b  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Active pharmaceutical ingredients; Cohesive force; Compression; Particle shape; Powder technology; Tableting; Tensile strength

Indexed keywords

ETHENZAMIDE;

ARTICLE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; FLUIDIZED BED; PARTICLE SIZE; TABLET; TENSILE STRENGTH;

EID: 20344387826     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20307     Document Type: Article

References (6)

1. Fukunaka T, Tom JW. 2003. R&D of milling technology in pharmaceutical industry. J Soc Powder Technol Jpn 40:655-663.
2. Fell JT, Newton JM. 1970. Determination of tablet strength by the diametral- compression test. J Pharm Sci 59:688-691.
3. Rumpf H. 1958. Grundlagen und methoden des granulierens. 1.Teil: Begriffe, anwendungen und eigenschaften der granulate. Chemie Ing Tech 30:144-158.
4. Shinohara K, Tanaka T. 1975. Ultimate tensile strength of cohesive powders based on non-uniform packing model. J Chem Eng Jpn 8:50-56.
5. Shinohara K, Capes CE. 1979. Effect of distributed loading on stress patterns in discoidal agglomerates during the diametral compression test. Powder Technol 24:179-186.
6. Shinohara K, Capes CE, Fouda AE. 1982. A theoretical model of the effect of distributed loading on the tensile strength of agglomerates as measured in the diametral compression test. Powder Technol 32:163-171.