Is there a role for helminths in the therapy of inflammatory bowel disease?

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 2, Issue 2, 2005, Pages 62-63

  Summers, Robert W ^a   Elliott, David E ^a   Weinstock, Joel V ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; PLACEBO;

CLINICAL PROTOCOL; CLINICAL TRIAL; CROHN DISEASE; DISEASE ACTIVITY; DISEASE MODEL; ENTERITIS; ERADICATION THERAPY; HELMINTH; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; INCIDENCE; MICROBIAL COLONIZATION; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; REMISSION; REVIEW; SAFETY; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ANIMALS; CLINICAL TRIALS; HUMANS; IMMUNOTHERAPY; INFLAMMATORY BOWEL DISEASES; TRICHURIASIS; TRICHURIS;

EID: 20344383731     PISSN: 17434378     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncpgasthep0087     Document Type: Review

References (9)

1. Carr I and Mayberry JF (1999) The effects of migration on ulcerative colitis: a three-year prospective study among Europeans and first-and second-generation South Asians in Leicester (1991-1994). Am J Gastroenterol 94: 2918-2922
2. Weinstock JV et al. (2004) Helminths and harmony: mounting evidence suggests that helminths help regulate mucosal inflammation. Gut 53: 7-9
3. Summers RW et al. (2005) Trichuris suis therapy in Crohn's disease. Gut 54: 87-90
4. Maizels RM and Yazdanbakhsh M (2003) Immune regulation by helminth parasites: cellular and molecular mechanisms. Nat Rev Immunol 3: 733-744
5. Elliott DE et al. (2003) Exposure to schistosome eggs protects mice from TNBS colitis. Am J Physiol 284: G385-G391
6. Moreels TG et al. (2004) Concurrent infection with Schistosoma mansoni attenuates inflammation-induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats. Gut 53: 99-107
7. Elliot DE et al. (2004) Heligmosomoides polygyrus inhibits established colitis in IL10 deficient mice. Eur J Immunol 34: 2690-2698
8. Yazdanbakhsh M et al. (2002) Allergy, parasites, and the hygiene hypothesis. Science 296: 490-494
9. Sewell D et al. (2003) Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int Immunol 15: 59-69