Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy

Pediatric Blood and Cancer

Volumn 45, Issue 1, 2005, Pages 60-63

  Spiller, Susan E ^a   Hawkins, Douglas S ^a   Finn, Laura S ^a   Sze, Raymond W ^a   Sybert, Virginia ^b,c  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Group Health Permanente   (United States)

Author keywords

Bone marrow metastases; Pancytopenia; Pediatric melanoma

Indexed keywords

IMATINIB;

ARTICLE; BONE MARROW BIOPSY; BONE MARROW DEPRESSION; BONE MARROW METASTASIS; BONE PAIN; CASE REPORT; CAUSE OF DEATH; CLINICAL FEATURE; DRUG RESPONSE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; LABORATORY TEST; MALE; MELANOCYTIC NEVUS; MELANOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCYTOPENIA; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; TREATMENT FAILURE; TUMOR VOLUME;

BONE MARROW NEOPLASMS; CHILD, PRESCHOOL; FATAL OUTCOME; HUMANS; MALE; MELANOMA; NEVUS, PIGMENTED; PANCYTOPENIA; SKIN NEOPLASMS;

EID: 20344367282     PISSN: 15455009     EISSN: None     Source Type: Journal    
DOI: 10.1002/pbc.20200     Document Type: Article

References (25)

1. Trozak DJ, Rowland WD, Hu F. Metastatic malignant melanoma in prepubertal children. Pediatrics 1975;71:191-204.
2. Devita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles & practice of oncology. 6th Edition. Lippincott: Williams & Wilkins; 2001. pp 2004-2051.
3. Ceballos PI. Ruiz-Maldonado R, Mihm MC. Melanoma in children. N Engl J Med 1995;332:656-662.
4. Liao AT, Chien MB, Narmada S, et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood 2002;100:585-593.
5. Castilla EE, Dutra MDG, Orioli-Parreiras IM. Epidemiology of congenital pigmented nevi: Incidence rates and relative frequencies. Br J Dematol 1981;104:307-315.
6. Marghoob AA. Congenital melanocytic nevi: Evaluation and management. Dermatol Clinics 2002;20:607-616.
7. Kaplan EN. The risk of malignancy in large congenital nevi. Plast Reconstr Surg 1974;53:421-428.
8. Lorentzen M, Pers M, Bretteville-Jensen G. The incidence of malignant transformation in giant pigmented nevi. Scand J Plast Reconstr Surg 1997;11:163-167.
9. Savage RA, Lucas FV, Hoffman GC. Melanoma in marrow aspirates. Am J Clin Pathol 1983;79:268-269.
10. Basile M, Moskowitz B, Harris J, et al. Malignant melanoma: Primary presentation in bone marrow and lymph node. Med Pediatr Oncol 1992;20:75-77.
11. Invernizzi R, Pecci A. A case of metastatic malignant melanoma with bone marrow involvement. Haematologica 2001;86:447.
12. Chim CS, Trendell Smith NJ. Primary malignant ocular melanoma: A bone marrow diagnosis. Br J Haematol 2001;112:2.
13. Schadendorf D, Dorn-Beineke A, Borelli S, et al. Limitations of the immunocytochemical detection of isolated tumor cells in frozen samples of bone marrow obtained from melanoma patients. Exp Dermatol 2003;12:165-171.
14. Basu D, Bhade B, Ghotekar L, et al. Malignant melanoma metastatic to bone marrow. Indian J Pathol Microbiol 2002;45:107-109.
15. Trefzer U, Schlegel C, Sterry W, et al. Fulminant intravascular disseminating malignant melanoma mimicking acute leukemia. Blood 1999;94:1483-1484.
16. Gallivan MVE, Lokich JJ. Carcinocythemia (carcinoma cell leukemia). Cancer 1984;53:1100-1102.
17. Balch CM, Buzaid AC, Atkins MB, et al. A new American joint committee on cancer staging system for cutaneous melanoma. Cancer 2000;88:1484-1490.
18. Byrd SE, Reyes-Mugica M, Darling CF, et al. MR of leptomeningeal melanosis in children. Eur J Radiology 1991;20:93-997
19. Ruiz-Maldonado R, Orozco-Covarrubias M. Malignant melanoma in children. Arch Dermatol 1997;133:363-371.
20. Pratt CB, Palmer MK, Thatcher N, et al. Malignant melanoma in children and adolescents. Cancer 1981;47:392-397.
21. Rodriguez-Galindo C, Pappo AS, Kaste SC, et al. Brain metastases in children with melanoma. Cancer 1997;79:2440-2445.
22. Melnik MK, Urdaneta LF, Al-Jurf AS, et al. Malignant melanoma in childhood and adolescence. The Am Surg 1986;52:142-147.
23. Saenz NC, Saenz-Badillos J, Busam K, et al. Childhood melanoma survival. Cancer 1999;85:750-754.
24. Bittencourt FV, Marghoob AA, Kopf AW, et al. Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics 2000;106:736-741.
25. Stadelman WK, Reintgen DS. Prognosis in malignant melanoma. Hematol Oncol Clin North Am 1998;12:767-795.