Very fast (and safe) inactivation of foot-and-mouth disease virus and enteroviruses by a combination of binary ethyleneimine and formaldehyde

Developments in Biologicals

Volumn 119, Issue , 2005, Pages 449-455

  Barteling, S J ^a   Cassim, N I ^b  

^a Simbar Consultancy   (Netherlands)

^b ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE; AZIRIDINE DERIVATIVE; FORMALDEHYDE; VIRUS ANTIGEN; VIRUS VACCINE;

ANIMAL; ARTICLE; CATTLE; CATTLE DISEASE; DOSE RESPONSE; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; IMMUNOLOGY; SERODIAGNOSIS; TREATMENT OUTCOME;

ANIMALS; ANTIGENS, VIRAL; AZIRIDINES; CATTLE; CATTLE DISEASES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; FORMALDEHYDE; NEUTRALIZATION TESTS; TREATMENT OUTCOME; VIRAL VACCINES;

EID: 20344365602     PISSN: 14246074     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (14)

1. Waldmann O, Pyl G, Hobohm KO, Mohlmann H: Die Entwicklung des Riemser Adsorbatimpfstoffes gegen Maul- und Klauenseuche und seine Herstellung. Zbl Bakt I Orig 1941;148:1.
2. Graves JH: Formaldehyde inactivation of foot-and-mouth disease virus as applied to vaccine preparation. Am J Vet Res 1963;24:1131.
3. Weslen T, Dinter Z: Then inactivation of foot-and-mouth disease virus by formali. Arch Ges Virusforsch 1957;7:394-402.
4. Barteling SJ, Woortmeijer R, Visser N: Innocuity testing of foot-and-mouth disease vaccines. I. Formaldehyde-inactivated alhydrogel vaccines. J Biol Stand 1983;11:297.
5. Barteling SJ, Woortmeijer R: Formaldehyde inactivation of foot-and-mouth disease virus. Conditions for the preparation of safe vaccine. Arch Virol 1984;80:103.
6. King AMQ, Underwood BO, McCahon D, Newman JWI, Brown F: Biochemical identification of viruses causing the 1981 outbreaks of foot-and-mouth disease in the U.K. Nature 1981;293:479.
7. Beck E, Strohmaier K: Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination. J Virol 1987;61:1621.
8. Brown F, Hyslop NSG, Crick J, Morrow AW: The use of acetyl-ethyleneimine in the production of inactivated foot-and-mouth disease vaccines. J Hyg (Camb) 1963b;61:337.
9. Bahnemann HG: Binary ethylenimine as an inactivant for foot-and-mouth disease virus and its application for vaccine production. Arch Virol 1975;47:47-56.
10. Bahnemann HG: "Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine. Vaccine 1990;8:299-303.
11. Rowlands et al: Stabilizing the immunizing antigen of foot-and-mouth disease virus by fixation with formaldehyde. Arch Ges Virusforsch 1972;39:274-283.
12. Mowat GN: Enhancement of immunizing potency of foot-and-mouth disease vaccine for cattle by treatment of the antigen with formaldehyde. Arch ges Virusforsch 1973;41:365-370.
13. Rweyemamu MM et al: Effect of formaldehyde (FA) and binary ethyleneimine (BEI) on the integrity of foot-and-mouth disease virus capsid. Rev sci tech Off. Int Epiz 1989;8:747-767.
14. Panina GF: Animal cell culture and FMD virus production in a large scale insuatrial roller bottle plant, in Spier R, Van Wezel AL (eds): Proc First Gen Meet Eur Soc Anim Cell Techn. Bilthoven, The Netherlands, RIVM, 1976, p 4.