Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 5, 2001, Pages 685-688

  Austin, Nigel E ^a   Avenell, Kim Y ^a   Boyfield, Izzy ^a   Branch, Clive L ^a   Hadley, Michael S ^a   Jeffrey, Phillip ^a   Johnson, Christopher N ^a   Macdonald, Gregor J ^a   Nash, David J ^a   Riley, Graham J ^a   Smith, Alexander B ^a   Stemp, Geoffrey ^a   Thewlis, Kevin M ^a   Vong, Antonio K K ^a   Wood, Martyn D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 1H ISOINDOLE; DOPAMINE 3 RECEPTOR BLOCKING AGENT; N [4 [2 (6 CYANO 1,2,3,4 TETRAHYDRO 2 ISOQUINOLINYL)ETHYL]CYCLOHEXYL] 4 QUINOLINECARBOXAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOPAMINERGIC SYSTEM; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CHO CELLS; CRICETINAE; DOPAMINE ANTAGONISTS; DRUG DESIGN; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3;

EID: 20244386800     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00037-3     Document Type: Article

References (12)