Differences in [99mTc]TRODAT-1 SPECT binding to dopamine transporters in patients with multiple system atrophy and Parkinson's disease

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 32, Issue 3, 2005, Pages 302-307

  Swanson, Randel L ^a   Newberg, Andrew B ^a,b   Acton, Paul D ^a   Siderowf, Andrew ^a   Wintering, Nancy ^a   Alavi, Abass ^a   Mozley, P David ^a   Plossl, Karl ^a   Udeshi, Michelle ^a   Hurtig, Howard ^a  

^a Division of Nuclear Medicine   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dopamine transporter; Multiple system atrophy; Parkinson's disease; Single photon emission computed tomography

Indexed keywords

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER; TRACER; CARRIER PROTEIN; DIAGNOSTIC AGENT; MEMBRANE PROTEIN; NERVE PROTEIN; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M TRODAT 1; TECHNETIUM TC 99M TRODAT-1; TROPANE DERIVATIVE;

ADULT; AGED; ARTICLE; BASAL GANGLION; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; NEUROPATHOLOGY; NEUROPHYSIOLOGY; PARKINSON DISEASE; PUTAMEN; SHY DRAGER SYNDROME; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; BRAIN; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; CONTROLLED CLINICAL TRIAL; METABOLISM; METHODOLOGY; MIDDLE AGED; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; DIAGNOSIS, DIFFERENTIAL; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; NERVE TISSUE PROTEINS; ORGANOTECHNETIUM COMPOUNDS; PARKINSON DISEASE; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 20244377990     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-004-1667-x     Document Type: Article

References (36)

1. Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999;163:94-8.
2. Wenning GK, Braune S. Multiple system atrophy: pathophysiology and management. CNS Drugs 2001;15:839-52.
3. Tison F, Yekhlef F, Chrysostome V, Balestre E, Quinn NP, Poewe W, Wenning GK. Parkinsonism in multiple system atrophy: natural history, severity (UPDRS-III), and disability assessment compared with Parkinson's disease. Mov Disord 2002;17:701-92.
4. Lang AE, Lozano AM. Parkinson's disease. First of two parts. N Engl J Med 1998;339:1044-53.
5. Lang AE, Lozano AM. Parkinson's disease. Second of two parts. N EnglJ Med 1998;339:1130-43.
6. Stern MB, Koller WC. Parkinson's disease. In: Stern MB, Koller WC, editors. Parkinsonian syndromes. New York: Marcel; 1993. p. 3-29.
7. Jankovic J. Pathophysiology and clinical assessment of motor symptoms in Parkinson's disease. In: Koller WC, editor. Handbook of Parkinson's disease. New York: Marcel; 1992. p. 129-57.
8. Rajput AH, Rozdilsky B, Rajput A. Accuracy of clinical diagnosis in parkinsonism - a prospective study. Can J Neurol Sci 1991;18:275-8.
9. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-4.
10. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001;57:1497-9.
11. Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 2002;125:861-70.
12. Hughes AJ, Colosimo C, Kleedorfer B, Daniel SE, Lees AJ. The dopaminergic response in multiple system atrophy. Neurol Neurosurg Psychiatry 1992;55:1009-13.
13. 99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers. J Nucl Med 2000;41:584-9.
14. 99mTc-TRODAT-1 imaging of multiple system atrophy. J Nucl Med 2004;45:49-55.
15. Ishikawa T, Dhawan V, Kazumata K, Chaly T, Mandel F, Neumeyer J, et al. Comparative nigrostriatal dopaminergic imaging with iodine-123-βCIT-FP/ SPECT and fluorine-18-FDOPA/PET. J Nucl Med 1996;37:1760-5.
16. Innis RB, Seibyl JP, Scanley BE, Laruelle M, Abi-Dargham A, Wallace E, et al. Single-photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease. Proc Natl Acad Sci USA 1993;90:11965-9.
17. Kung HF, Kim HJ, Kung MP, Meegala SK, Plossl K, Lee HK. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med 1996;23:1527-30.
18. 99m tropane for imaging dopamine transporters. J Nucl Med 1998;39:2069-76.
19. Ward CD, Gibbs WR. Research diagnostic criteria for Parkinson's disease. In: Streifler MB, Korczyn AD, Melamed E, Youdin MBH, editors. Advances in neurology: anatomy, pathology and therapy. New York: Raven; 1990.
20. 99mTc]TRODAT-1 to the central dopamine transporters in rats. Eur J Nucl Med 1998;25:31-9.
21. Mozley LH, Gur RC, Mozley PD, Gur RE. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry 2001;158:1492-9.
22. Golden CJ, Hammeke TA, Purisch AD. Luria-Nebraska neuropsychological battery manual. Los Angeles: Western Psychological; 1980.
23. Reitan RM, Wolfson D. The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation. Tuscon: Neuropsychology; 1985.
24. Harley JP, Leuthold CA, Matthews CG, Bergs LE. Wisconsin neuropsychological test battery t-score norms for older Veterans Administration Medical Center patients. Madison: Matthews; 1980.
25. Kim HJ, Karp JS, Mozley PD, Yang SO, Moon DH, Kung HF, et al. Stimulating technetium-99m cerebral perfusion studies with a three-dimensional Hoffmann brain phantom: collimator and filter selection in SPECT neuroimaging. Ann Nucl Med 1996;10:153-60.
26. Chang LT. A method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci 1978;25:638-43.
27. Mozley PD, Acton PD, Barraclough ED, Plossl K, Gur RC, Alavi A, et al. Effects of age on dopamine transporters in healthy humans. J Nucl Med 1999;40:1812-7.
28. Kim YJ, Ichise M, Ballinger JR, Vines D, Erami SS, Tatschida T, Lang AE. Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP. Mov Disord 2002;17:303-2.
29. 123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin 2003;42:31-8.
30. 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann Neurol 1990;28:547-55.
31. Antonini A, Leenders KL, Vontobel P, Maguire RP, Missimer J, Psylla M, Gunther I. Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease. Brain 1997;120:2187-95.
32. 11C-raclopride and positron emission tomography. Ann Neurol 1992;31:184-92.
33. Pirker W, Asenbaum S, Wenger S, Kornhuber J, Angelberger P, Deecke L, et al. Iodine-123-epidepride-SPECT: studies in Parkinson's disease, multiple system atrophy and Huntington's disease. J Nucl Med 1997;38:1711-7.
34. Ghaemi M, Hilker R, Rudolf J, Sobesky J, Heiss WD. Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging. J Neurol Neurosurg Psychiatry 2002;73:517-23.
35. 123IBZM-SPECT. J Neurol Neurosurg Psychiatry 1994;57:1047-56.
36. Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP. Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord 1997;12:133-47.